PVL positive Staphylococcus aureus skin infections

Diagnosis and management of hidradenitis suppurativa

“…17 Repeated boils at body sites that are not typical for hidradenitis should be investigated with bacteriology swabs, looking particularly for Panton-Valentine leucocidin positive S aureus, which can cause recurrent boils that do not respond to treatment. 18 Pyogenic skin infections occurring in sites atypical for hidradenitis may indicate defects of immune function. If this is suspected, initial screening tests should include blood glucose; full blood count, differential, and film; IgA, IgM, IgG, and IgE; total complement; HIV screening; serum protein electrophoresis; and urine for Bence-Jones proteins.…”

Synthesis and antibacterial activity of monocyclic 3-carboxamide tetramic acids

“…Of particular interest is that 3-carboxamide analogues, especially 2b , have shown bioactivity against various Gram-positive bacteria including clinically resistant strains such as MRSA, fluoroquinolone-resistant S. aureus , MDRSP, penicillin and erythromycin-resistant S. pneumonia and VRE as well as Gram-negative H. influenzae . Further optimisation, especially for overcoming high plasma-protein binding, is warranted but these compounds may be suitable for an evaluation for topical use [31–32]. Significantly, these results suggest that a drug discovery approach based upon deconstruction–reconstruction inspired by suitable natural products with demonstrable biological activity provides a route for the rapid assembly of compound libraries, which, even if not fully optimized, provide a useful starting point for further elaboration.…”

Serious life-threatening multifocal infection in a child, caused by Panton-Valentine leucocidin-producingStaphylococcus aureus(PVL-MSSA)

“…The toxin was first described by Panton and Valentine in 1932. The PVL genes are carried by approximately <2% of both MRSA and MSSA according to the data published in 2005,6 and the majority of the isolates were PVL-producing MSSA (62%) 7. However, the data from the UK in 2010 demonstrated that 20% of the S. aureus isolated from skin or soft tissue infections was PVL positive 8…”