Serious life-threatening multifocal infection in a child, caused by Panton-Valentine leucocidin-producing<i>Staphylococcus aureus</i>(PVL-MSSA)

Irenji, Neda; Pillai, Suresh; West-Jones, Jennifer Susan

doi:10.1136/bcr-2017-222138

Cited by 6 publications

(10 citation statements)

References 11 publications

(16 reference statements)

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“…Multiple family members may be affected. In rare cases, patients may develop primary or secondary necrotizing pneumonia caused by PVL‐positive S. aureus . This complication runs a particularly severe course even in immunocompetent individuals and may even be fatal in children .…”

Section: Resultsmentioning

confidence: 99%

Recurrent mucocutaneous infections caused by PVL‐positive Staphylococcus aureus strains: a challenge in clinical practice

Hischebeth

Altengarten

Exner

et al. 2020

J Deutsche Derma Gesell

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Background: Recurrent mucocutaneous infections caused by PVL-positive Staphylococcus (S.) aureus strains represent an increasing problem in Germany. Although there have been several outbreaks at day care centers and in urban communities in recent years, there are currently no diagnostic algorithms or treatment recommendations for these particular infections in Germany. Methods:We performed a literature search in the PubMed/MEDLINE database with the goal of developing an algorithm for diagnosis and treatment of these infections. National and international recommendations were also considered.Results: Panton-Valentine leukocidin (PVL) is a pore-forming protein produced by certain S. aureus strains. Both methicillin-susceptible (MSSA) and methicillin-resistant S. aureus (MRSA) strains may carry the lukS-lukF gene responsible for PVL production. The clinical presentation of infections caused by PVL-positive S. aureus ranges from isolated recurrent abscesses to extensive furunculosis. Despite adequate treatment of primary infections, approximately 40 % of patients develop recurrent disease. The choice of treatment regimen is guided by the clinical presentation of the infection. In addition, some scientific literature recommends bacteriological screening of patients and their contacts, followed by decolonization of affected individuals. Conclusions:The present article focuses on the pathogenesis and risk factors of recurrent mucocutaneous infections caused by PVL-positive S. aureus strains and proposes a diagnostic and therapeutic algorithm for optimal patient care.

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Section: Resultsmentioning

confidence: 99%

Recurrent mucocutaneous infections caused by PVL‐positive Staphylococcus aureus strains: a challenge in clinical practice

Hischebeth

Altengarten

Exner

et al. 2020

J Deutsche Derma Gesell

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“…Since 2010, we have identified 15 reported cases of paediatric PVL-SA severe infections and Table 1 summarizes the main results of these reports regarding the clinical presentations, radiological findings, treatment and outcome [2][3][4][5][15][16][17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

et al. 2021

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Background Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. A literature review starting from 2010 was also performed in order to discuss clinical presentations, radiological findings, treatment and outcome. Case presentation This is a case of a 6-month-old boy who rapidly developed high fever and poor general condition. He was diagnosed as having multiple muscular abscesses, multiple foci of osteomyelitis and bloodstream infections caused by Panton-Valentine leukocidin Methicillin-resistant Staphylococcus aureus. He received intravenous antibiotics and surgical drainage of the abscess with progressive recovery. Conclusion Our report highlights the importance of improving awareness of this severe infection, as a prompt diagnosis and adequate manage is essential in order to save life and to prevent serious complications.

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“…Mehrere Familienmitglieder können betroffen sein. In seltenen Fällen kann es primär oder sekundär zu einer nekrotisierenden Pneumonie durch PVL‐positive S. aureus‐ Stämme kommen . Diese verläuft auch bei immunkompetenten Personen ausgesprochen schwer und kann im Kindesalter sogar zum Tod führen .…”

Section: Ergebnisseunclassified

Rezidivierende mukokutane Infektionen durch PVL‐positive Staphylococcus aureus‐Stämme: Eine Herausforderung im klinischen Alltag

Hischebeth

Altengarten

Exner

et al. 2020

J Deutsche Derma Gesell

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Hintergrund: Rezidivierende mukokutane Infektionen durch PVL-positive Staphylococcus (S.) aureus-Stämme stellen in Deutschland ein zunehmendes Problem dar. In den letzten Jahren wurden Ausbrüche in Kindertagesstätten und Kommunen beschrieben. Dennoch liegen zurzeit keine diagnostischen Algorithmen oder Therapieempfehlungen für die entsprechenden Infektionen in Deutschland vor. Methode: Eine Literaturrecherche in der Datenbank PubMed/MEDLINE erfolgte mit dem Ziel, einen diagnostischen und therapeutischen Algorithmus zu erarbeiten. Zudem wurden nationale und internationale Empfehlungen berücksichtigt. Ergebnisse: Panton-Valentine Leukozidin (PVL) ist ein porenbildendes Protein, das von bestimmten S. aureus-Stämmen produziert wird. Sowohl Methicillin-sensible (MSSA) als auch Methicillin-resistente S. aureus (MRSA)-Stämme können das für die PVL-Produktion verantwortliche Gen lukS-lukF besitzen. Das klinische Bild der durch einen PVL-positiven S. aureus verursachten Infektionen erstreckt sich von einzelnen rezidivierenden Abszessen bis hin zu einer ausgedehnten Furunkulose. Bei etwa 40 % der Patienten kommt es zu Rezidiven der Beschwerden trotz einer konsequenten Behandlung der Erstinfektion. Die Therapie variiert je nach klinischem Bild der jeweiligen Infektion. Zudem wird in der Literatur eine Screeninguntersuchung der Patienten und ihrer engen Kontaktpersonen sowie eine bakterielle Dekolonisation der Betroffenen empfohlen. Schlussfolgerungen: Diese Arbeit fokussiert auf die Pathogenese und Risikofaktoren der rezidivierenden mukokutanen Infektionen durch PVL-positive S. aureus-Stämme und versucht einen diagnostischen und therapeutischen Algorithmus zur optimalen Patientenversorgung vorzuschlagen. SummaryBackground: Recurrent mucocutaneous infections caused by PVL-positive Staphylococcus (S.) aureus strains represent an increasing problem in Germany. Although there have been several outbreaks at day care centers and in urban communities in recent years, there are currently no diagnostic algorithms or treatment recommendations for these particular infections in Germany. PathogenesePanton-Valentine Leukozidin (PVL) ist ein porenbildendes Protein, das von bestimmten S. aureus-Stämmen produziert wird. Sowohl Methicillin-sensible (MSSA) als auch Methods: We performed a literature search in the PubMed/MEDLINE database with the goal of developing an algorithm for diagnosis and treatment of these infections. National and international recommendations were also considered.

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Serious life-threatening multifocal infection in a child, caused by Panton-Valentine leucocidin-producingStaphylococcus aureus(PVL-MSSA)

Cited by 6 publications

References 11 publications

Recurrent mucocutaneous infections caused by PVL‐positive Staphylococcus aureus strains: a challenge in clinical practice

Recurrent mucocutaneous infections caused by PVL‐positive Staphylococcus aureus strains: a challenge in clinical practice

Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

Rezidivierende mukokutane Infektionen durch PVL‐positive Staphylococcus aureus‐Stämme: Eine Herausforderung im klinischen Alltag

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