PUVA‐bath photochemotherapy (PUVA‐soak therapy) of recalcitrant dermatoses of the palms and soles

Behrens, Stefanie; Kobyletzki, Gregor von; Gruss, Claus; Reuther, T.; Altmeyer, Peter; Kerscher, Martina

doi:10.1111/j.1600-0781.1999.tb00056.x

Cited by 55 publications

(43 citation statements)

References 30 publications

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“…Topical PUVA treatment has been reported in several studies to be an effective treatment for palmoplantar dermatoses (1)(2)(3)(4). These studies usually dealt with small numbers of patients; nevertheless, most of them agree that PUVA is a relatively effective treatment with few side effects.…”

Section: Introductionmentioning

confidence: 97%

The use of topical PUVA for palmoplantar dermatoses

Kassem¹,

Pavlotsky

Dorit

et al. 2006

Journal of Dermatological Treatment

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Palmoplantar dermatoses have a tendency to be chronic and are frequently recalcitrant to treatment. We summarize our experience with paint PUVA in the treatment of 125 patients with palmoplantar dermatoses between the years 1996 and 2000. The dominant clinical picture of the lesions was hyperkeratosis in 84, pustulosis in 11 and exudative dermatitis in the remaining 30 patients. The treatment was applied thrice weekly on alternate days. The affected skin was painted with methoxsalen 0.1% solution, and exposed 30 minutes later to UVA radiation, starting at 0.25 J/cm(2), with increments of 0.25-0.50 J/cm(2) every third treatment. Complete response was considered if all signs disappeared, and partial response if improvement occurred in more than 75% of each of the clinical findings of scaling erythema, fissuring, pustule formation and infiltration. Sixty-nine percent of the patients had a good response (i.e. a complete or partial response), which was achieved in 78.5% of the exudative dermatitis lesions, but in only 46.7% of the pustular lesions. The average time to achieve good response was 13 weeks (range 1-42), with an average total dose of 50 J/cm(2) (range 0.50-366). Maintenance therapy every 1-4 weeks was recommended for all responding patients, but only 58 consented and were treated for an average period of 10 additional weeks. Side effects were minor and transient, mainly mild first-degree superficial skin burns in 10 patients, and patchy hyperpigmentation in three patients, which resolved after a few weeks.

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Section: Introductionmentioning

confidence: 97%

The use of topical PUVA for palmoplantar dermatoses

Kassem¹,

Pavlotsky

Dorit

et al. 2006

Journal of Dermatological Treatment

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“…Bath-water PUVA with 8-MOP has been shown to be beneficial for many skin disorders: psoriasis (12), granuloma anulare (13), atopic dermatitis (14), lichen planus (15), lichen sclerosus et atrophicans (16), localized scleroderma (17), chronic palmoplantar eczema (18,19) and lymphomatoid papulosis (20). Comparative studies in psoriasis showed that bath-water PUVA is as effective as oral PUVA but requires less cumulative UVA (12,21,22).…”

mentioning

confidence: 98%

Bath‐water PUVA Therapy with 8‐Methoxypsoralen in Mycosis Fungoides

Weber¹,

Schmuth²,

Sepp³

et al. 2005

Acta Dermato-Venereologica

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PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively evaluated the outcomes of bath-water delivery of 8-MOP (1 mg l(-1)) in 16 patients with early stage mycosis fungoides. In all patients complete response was achieved after a mean duration of 63 days requiring 29 treatments and a mean cumulative UVA dose of 33 J cm(-2). The time to relapse after complete clinical clearance was 45.6 (+/-9.2) weeks. In comparison, oral PUVA therapy with 8-MOP resulted in complete response after 64.5 days (25.8 treatments) with a mean relapse-free period of 30 (+/-3.5) weeks. We conclude that bath-water PUVA therapy with 8-MOP is a valuable photo-therapeutic alternative, which should be considered for patients in whom systemic psoralen cannot be used.

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“…This audit was designed to evaluate the effectiveness of topical PUVA for hand and foot dermatoses in the NHSCT. As current literature has shown that in excess of 70% response can be expected from topical PUVA (6–10), this figure was used as our standard. Additional aims of this audit were to compare the effectiveness of topical PUVA in eczema vs. psoriasis, hands vs. feet, and also between the two UVA treatment protocols in use in the NHSCT.…”

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confidence: 99%