Efficacy of topical PUVA soaks for palmoplantar dermatoses: an audit

Abstract

UV dose increments should be clearly defined to avoid excess caution at the expense of an adequate patient response, and a minimum of 20 treatments administered to all patients, if tolerated.

Psoralen plus ultraviolet A (PUVA) soaks and UVB TL01 treatment for chronic hand dermatoses

“…The effect was good for psoriasis in half of the treatment courses concerning PUVA soaks, and in one third of the courses with TL01. The effect of PUVA soaks are in accordance with results published by O'Kane and coworkers 16 and Schempp and coworkers. 17 …”

British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen–ultraviolet A therapy 2015

“…141,142 Uncontrolled studies of topical PUVA have suggested this to be effective treatment with clearance or considerable improvement reported in 58-81% of dyshidrotic eczema and 50-67% of hyperkeratotic eczema. [143][144][145][146][147][148][149][150][151][152][153][154] However, evidence from comparative studies was less convincing. A left-right, withinpatient study (n = 15) with 8-MOP paint vs. placebo in dyshidrotic eczema found no difference between the two groups, and no patient achieved clearance.…”

“…163 Uncontrolled studies have reported clearance or significant improvement occurring in 58-87% of patients treated with topical psoralen. 143,[146][147][148]150,151,[164][165][166][167] In a randomized, left-right, within-patient study in patients with hand and foot dermatoses (psoriasis, n = 11), topical PUVA (20% 8-MOP gel) was compared with UVA, and PUVA was suggested to be more effective overall, but the results were not analysed separately according to the different dermatoses investigated. 156 No patient was reported as being cleared in either group.…”

“…Uncontrolled studies of topical PUVA have suggested this to be effective treatment with clearance or considerable improvement reported in 58–81% of dyshidrotic eczema and 50–67% of hyperkeratotic eczema . However, evidence from comparative studies was less convincing.…”

“…Uncontrolled studies have reported clearance or significant improvement occurring in 58–87% of patients treated with topical psoralen …”