Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population

Aguilera, Mari; Barrantes‐Vidal, Neus; Arias, Bárbara; Moya, Jorge; Villa, Helena; Ibáñez, Manuel I.; Ruipérez, Marı́a A.; Ortet, Generós; Fañanás, Lourdes

doi:10.1002/ajmg.b.30705

Cited by 64 publications

(57 citation statements)

References 33 publications

(44 reference statements)

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“…Notably, the association of COMT Val158Met and cognitive function was reported to be dependent on ethnicity. In Caucasians, the Met allele was reported to be associated with better cognitive function (Bruder et al 2005;Aguilera et al 2008). Conversely, studies of East Asian samples indicated that the Val allele is associated with better cognitive function (Cheon et al 2008;Yeh et al 2009;Wang et al 2013).…”

Section: Introductionmentioning

confidence: 87%

Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity

Wang

Yuan

et al. 2016

J Neuroimmune Pharmacol

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The COMT (catechol-O-methyltransferase) Val158Met polymorphism (rs4680) is a potential susceptibility variant for major depressive disorder (MDD). Although many genetic studies have examined the association between MDD and this polymorphism, the results were inconclusive. In the present study, we conducted a series of meta-analyses of samples consisting of 2905 MDD cases and 2403 controls with the goal of determining whether this variant indeed has any effect on MDD. We revealed a significant association in the comparison of Val/Val + Val/Met vs. Met/Met (OR =1.180; 95 % CI = 1.019, 1.367; P = 0.027), Val/Met vs. Val/Val (OR =1.18; 95 % CI = 1.038, 1.361; P = 0.013), and Val/Met vs. Met/Met (OR =1.229; 95 % CI = 1.053, 1.435; P = 0.009). Further meta-analyses of samples with European ancestry demonstrated a significant association of this SNP with MDD susceptibility in Val/Val + Val/Met vs. Met/Met (OR =1.231, 95 % CI = 1.046, 1.449; P = 0.013) and Val/Met vs. Met/Met (OR =1.284, 95 % CI = 1.050, 1.484; P = 0.012). For the samples with East Asian ancestry, we found a significant association in both allelic (Val vs. Met: OR =0.835; 95 % CI = 0.714, 0.975; P = 0.023) and genotypic (Met/Met + Val/Met vs. Val/Val: OR =1.431, 95 % CI = 1.143, 1.791; P = 0.002; Val/Met vs. Val/Val: OR =1.482, 95 % CI = 1.171, 1.871; P = 0.001) analyses. No evidence of heterogeneity among studies or publication bias was observed. Together, our results indicate that the COMT Val158Met polymorphism is a vulnerability factor for MDD with distinct effects in different ethnic populations.

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Section: Introductionmentioning

confidence: 87%

Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity

Wang

Yuan

et al. 2016

J Neuroimmune Pharmacol

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“…No association between COMT and any cognitive measures 42 or unaffected relatives. 40 Moreover, an interaction between the COMT Val 158 Met polymorphism and the MTHFR C677T mutation on WCST performance has been found in patients with schizophrenia, with COMT Val/Val carriers who had at least 1 copy of the MTHFR T allele making more perseverative errors.…”

Section: Wisconsin Card Sorting Test (Wcst)mentioning

confidence: 92%

“…40,64 In healthy individuals, the Val/Val and Val/Met genotypes have been associated with worse performance in terms of commission errors, 47 context processing 44 and reaction time variability in some studies, 55 whereas other studies reported no association. 23,40,42,64 This inconsistency may be related to the use of different versions of the CPT across studies (for details about the different versions of the tasks used, see Appendix 1, Table S1). Interestingly, 1 study reported an interaction between the COMT Val 158 Met polymorphism and the DAT 40 bp variable number tandem repeat; participants homozygous for both the COMT Val allele and the DAT 10 allele exhibited worse performance in terms of commission errors.…”

Section: Continuous Performance Test (Cpt)mentioning

confidence: 99%

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation

Ira

Zanoni

Ruggeri

et al. 2013

J Psychiatry Neurosci

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“…The catechol-O-methyltransferase (COMT ) gene codes for an enzyme that metabolizes catecholamines and it is particularly important for metabolizing prefrontal dopamine. A single point mutation in the COMT gene (val158met) is associated with differences in cognitive abilities (de Frias et al, 2004;Bruder et al, 2005;Bertolino et al, 2006;Aguilera et al, 2008;Stokes et al, 2011;Buckert et al, 2012). There is also some evidence that COMT genotype has a significant effect on the volume of gray matter and parietal lobe activity (Dumontheil et al, 2011).…”

Section: Mechanisms Of Tdcsmentioning

confidence: 99%

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

Jones¹,

Crane²,

Feenstra³

et al. 2012

PsycEXTRA Dataset

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The nature of parietal contributions to working memory (WM) remain poorly understood but of considerable interest. We previously reported that posterior parietal damage selectively impaired WM probed by recognition (Berryhill and Olson, 2008a). Recent studies provided support using a neuromodulatory technique, transcranial direct current stimulation (tDCS) applied to the right parietal cortex (P4). These studies confirmed parietal involvement in WM because parietal tDCS altered WM performance: anodal current tDCS improved performance in a change detection task, and cathodal current tDCS impaired performance on a sequential presentation task. Here, we tested whether these complementary results were due to different degrees of parietal involvement as a function of WM task demands, WM task difficulty, and/or participants' WM capacity. In Experiment 1, we applied cathodal and anodal tDCS to the right parietal cortex and tested participants on both previously used WM tasks. We observed an interaction between tDCS (anodal, cathodal), WM task difficulty, and participants' WM capacity. When the WM task was difficult, parietal stimulation (anodal or cathodal) improved WM performance selectively in participants with high WM capacity. In the low WM capacity group, parietal stimulation (anodal or cathodal) impaired WM performance. These nearly equal and opposite effects were only observed when the WM task was challenging, as in the change detection task. Experiment 2 probed the interplay of WM task difficulty and WM capacity in a parametric manner by varying set size in the WM change detection task. Here, the effect of parietal stimulation (anodal or cathodal) on the high WM capacity group followed a linear function as WM task difficulty increased with set size. The low WM capacity participants were largely unaffected by tDCS. These findings provide evidence that parietal involvement in WM performance depends on both WM capacity and WM task demands. We discuss these findings in terms of alternative WM strategies employed by low and high WM capacity individuals. We speculate that low WM capacity individuals do not recruit the posterior parietal lobe for WM tasks as efficiently as high WM capacity individuals. Consequently, tDCS provides greater benefit to individuals with high WM capacity.

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Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population

Cited by 64 publications

References 33 publications

Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity

Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

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