Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection

Chun, Ji Yong; Bae, Joon Seol; Park, Tae June; Kim, Jason Y.; Park, Byung Lae; Cheong, Hyun Sub; Lee, Hyo Suk; Kim, Yoon Jun; Shin, Hyoung Doo

doi:10.5483/bmbrep.2009.42.12.834

Cited by 12 publications

(9 citation statements)

References 40 publications

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“…Moreover, the DNMT1 rs2228611 SNP modified associations between urinary cadmium and hypomethylation of LINE-1 repeated sequences [30]. In addition to these findings, the two intronic polymorphisms rs2241531 and rs4804490 of DNMT1 may be associated with hepatitis B virus (HBV) clearance and protection from the development of hepatocellular carcinoma [31]. …”

Section: Discussionmentioning

confidence: 99%

DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population

et al. 2013

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Studies have demonstrated that changes in DNA methylation of cancer related genes can be an elementary process accounting for ovarian tumorigenesis. Therefore, we evaluated the possible association of single nucleotide polymorphisms (SNPs) of DNA methyltransferases (DNMTs) genes, including DNMT1, DNMT3B, and DNMT3A, with ovarian cancer development in the Polish population. Using PCR–RFLP and HRM analyses, we studied the prevalence of the DNMT1 rs8101626, rs2228611 and rs759920, DNMT3A rs2289195, 7590760, rs13401241, rs749131 and rs1550117, and DNMT3B rs1569686, rs2424913 and rs2424932 SNPs in patients with ovarian cancer (n = 159) and controls (n = 180). The lowest p values of the trend test were observed for the DNMT1 rs2228611 and rs759920 SNPs in patients with ovarian cancer (ptrend = 0.0118 and ptrend = 0.0173, respectively). Moreover, we observed, in the recessive inheritance model, that the DNMT1 rs2228611 and rs759920 SNPs are associated with an increased risk of ovarian cancer development [OR 1.836 (1.143–2.949), p = 0.0114, pcorr = 0.0342, and OR 1.932 (1.185–3.152), p = 0.0078, pcor=0.0234, respectively]. However, none of other nine studied SNPs displayed significant contribution to the development of ovarian cancer. Furthermore, haplotype and multifactor dimensionality reduction analysis of the studied DNMT1, DNMT3B, and DNMT3A polymorphisms did not reveal either SNP combinations or gene interactions to be associated with the risk of ovarian cancer development. Our results may suggest that DNMT1 variants may be risk factors of ovarian cancer.Electronic supplementary materialThe online version of this article (doi:10.1007/s11033-013-2589-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population

et al. 2013

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“…However, some family and twin studies show that host genetic factors are the probable cause influencing the outcome of HBV infection [4,5]. Indeed, our previous studies have demonstrated that genetic variations in histone deacetylase 10, Fas/Fas ligand, transforming growth factor-α/β1, interleukin (IL)10, monocyte chemotactic protein-1, cyclin D2, DNA methyltransferase 1, insulin-like growth factor 2 and secreted phosphoprotein-1 are related to HBV clearance [6,7,8], HCC progression [9,10,11,12], or both [13,14]. In spite of these results, associations of HBV-related liver diseases with other host genetic diversities still need further investigation.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms near <b><i>Interleukin 28B</i></b> Gene Are Not Associated with Hepatitis B Virus Clearance, Hepatitis B e Antigen Clearance and Hepatocellular Carcinoma Occurrence

et al. 2013

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Background: Polymorphisms near the IL28B gene have been proposed to be strongly associated with treatment response and the rate of spontaneous clearance of hepatitis C virus infection, and treatment response of hepatitis B virus (HBV) infection. In this study, we aimed to determine whether these polymorphisms could affect natural courses of HBV infection. Methods: Genetic variations were identified through direct DNA sequencing using TaqMan assay in 1,439 patients with past or present HBV infection. Subjects included 404 spontaneously recovered patients, 313 chronic hepatitis B (CHB) patients, 305 liver cirrhosis (LC) patients and 417 hepatocellular carcinoma (HCC) patients. Three polymorphisms near the IL28B gene, rs8099917T>G, rs12979860C>T and rs12980275A>G, were identified. Associations between these polymorphisms and HBV clearance, hepatitis B e antigen (HBeAg) clearance as well as HCC occurrence among patients were analyzed using logistic regression analyses adjusted for age and gender. Results: There were no significant associations between these polymorphisms and the HBV clearance both in CHB and LC groups. Similarly, these polymorphisms showed no significant associations with HBeAg clearance and the occurrence of HCC either. Discussion: No significant association was identified between polymorphisms near the IL28B gene and the natural courses of chronic HBV infection, including the HBV clearance and HCC occurrence.

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“…queensu.ca/F-SNP/) (Lee and Shatkay, 2008), DNMT1 rs8101626 on intron 39 of chromosome 19 is predicted to affect the transcriptional regulation of DNMT1 mRNA, whereas DNMT3A rs34048824 on intron 2 of chromosome 2 is predicted to affect the transcriptional regulation of DNMT3A mRNA. Previous studies showed that other intron polymorphisms of DNMT1 + 34542G N C, + 38565G N T, rs10420321 A N G and rs2288349 G N A and DNMNT3A rs11887120 G N A and rs11695471 A N T were associated with disease risk (Kelemen et al, 2008;Chun et al, 2009;Jiang et al, 2012;Tao et al, 2015). Polymorphisms located in introns may affect gene expression by altering mRNA splicing (Moyer et al, 2011), and this could affect cancer susceptibility (Malkinson and You, 1994).…”

Section: Discussionmentioning

confidence: 96%

Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma

Yang

Huang

Shiue

et al. 2016

Toxicology and Applied Pharmacology

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Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection

Cited by 12 publications

References 40 publications

DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population

DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population

Polymorphisms near <b><i>Interleukin 28B</i></b> Gene Are Not Associated with Hepatitis B Virus Clearance, Hepatitis B e Antigen Clearance and Hepatocellular Carcinoma Occurrence

Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma

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