Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma

Yang, Shu; Huang, Chao Yuan; Shiue, Horng Sheng; Pu, Yeong-Shiau; Hsieh, Yi Hsun; Chen, Wei Jen; Lin, Ying; Hsueh, Yu Mei

doi:10.1016/j.taap.2016.06.011

Cited by 11 publications

(15 citation statements)

References 64 publications

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“…The 28 remaining articles were evaluated further for eligibility. Finally, 16 articles were included in the present meta-analysis [6–21]. …”

Section: Resultsmentioning

confidence: 99%

“…Among them, nine articles containing 3378 cases and 4244 controls surveyed the association between rs16999593 (T/C) and cancer risk [6, 7, 9–15]; 11 studies on the relation between rs2228611 (G/A) and cancer risk included 3643 cases and 3866 controls [6–8, 10, 11, 13, 14, 18–21]; and three publications containing 1343 cases and 1309 controls explored the correlation of rs2228612 (A/G) with cancer risk [7, 16, 17]. The populations surveyed in the nine rs16999593 (T/C) studies were all Chinese [6, 7, 9–15].…”

Section: Resultsmentioning

confidence: 99%

“…The populations surveyed in the nine rs16999593 (T/C) studies were all Chinese [6, 7, 9–15]. In the rs2228611 (G/A) studies, nine of the populations were Chinese [6, 7, 10, 11, 13, 14, 19–21], one was Iranian [8], and one was Polish [18]. In the rs2228612 (A/G) studies the populations were either Caucasian [16] or Chinese [7, 17].…”

Section: Resultsmentioning

confidence: 99%

“…In the rs2228612 (A/G) studies the populations were either Caucasian [16] or Chinese [7, 17]. The genotyping methods used to detect the DNMT1 polymorphisms included sequencing, MassARRAY, PCR-RFLP, MALDI-TOF, TaqMan, and SNPlex [6–21]. We used subgroup analyses to explore the effects of different cancer types and genotyping methods on the associations of increased risk of cancer with the DNMT1 rs16999593 (T/C) and rs2228611 (G/A) polymorphisms.…”

Section: Resultsmentioning

confidence: 99%

“…The SNPs rs16999593 (T/C) and rs2228612 (G/A) were initially found to be associated with risk of breast cancer [6, 7], while SNP rs2228611 (A/G) was linked to gastric cancer [8]. Subsequently, a number of studies have concentrated on the relationships between DNMT1 polymorphisms and risks of different cancers [6, 7, 9–21]. However, the results from these studies are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Liu

Sun

et al. 2017

BioMed Research International

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Previous studies have examined the associations of DNA methyltransferase 1 (DNMT1) polymorphisms, including single nucleotide polymorphisms rs16999593 (T/C), rs2228611 (G/A), and rs2228612 (A/G), with cancer risk. However, the results are inconclusive. The aim of this meta-analysis is to elucidate the associations between DNMT1 polymorphisms and cancer susceptibility. The PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure databases were searched systematically to identify potentially eligible reports. Odd ratios and 95% confidence intervals were used to evaluate the strength of association between three DNMT1 polymorphisms and cancer risk. A total of 16 studies were finally included in the meta-analysis, namely, nine studies of 3378 cases and 4244 controls for rs16999593, 11 studies of 3643 cases and 3866 controls for rs2228611, and three studies of 1343 cases and 1309 controls for rs2228612. The DNMT1 rs2228612 (A/G) polymorphism was significantly related to cancer risk in the recessive model. The meta-analysis also suggested that DNMT1 rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer. In future research, large-scale and well-designed studies are required to verify these findings.

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“…The 28 remaining articles were evaluated further for eligibility. Finally, 16 articles were included in the present meta-analysis [6–21]. …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Liu

Sun

et al. 2017

BioMed Research International

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Inorganic arsenic‐mediated upregulation of AS3MT promotes proliferation of nonsmall cell lung cancer cells by regulating cell cycle genes

Sun

Tan

Wang

et al. 2020

Environmental Toxicology

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Long‐term arsenic exposure can promote cancer through epigenetic mechanisms, and arsenite methyltransferase (AS3MT) plays an important role in this process. However, the expression patterns and mechanisms of AS3MT in arsenic carcinogenesis remain unclear. In this study, we found that the AS3MT was overexpressed in arsenic exposed population, non‐small cell lung cancer (NSCLC) tissues, and A549 cells with sodium arsenite (NaAsO2) treatment for 48 hours. Besides, the level of AS3MT expression was positively correlated with the concentrations of urinary total arsenic (tAs), inorganic arsenic (iAs), methanearsonic acid (MMA), and dimethylarsinic acid (DMA) in all subjects. Functional experiments demonstrated that siRNA‐mediated knockdown of AS3MT significantly inhibited proliferation of A549 cells. Mechanism investigation revealed that silencing of AS3MT inhibited proliferation by increasing mRNA expression levels of p21 and E2F1, and inhibiting CDK1, CDK2, CDK4, CDK6, Cyclin A2, Cyclin E1, Cyclin E2, and PCNA mRNA expression. Therefore, arsenic increased AS3MT expression in vivo and in vitro, which could directly act on the cell and affect the progression of NSCLC by regulating cell cycle genes.

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