Purulent meningitis due to spontaneous anterior sacral meningocele perforation. Case report

Fiumara, Francesco; N, Foti; Gambardella, Antonio; Mazzeo, Anna Teresa; Oliveri, R. L.; Pagano, V D; Quattrone, Aldo

doi:10.1007/bf02333622

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…37 In this study, six cases had infantile meningitis, which is interestingly related to meningomyelocele in some cases. 38 Evidence of a sacral dimple, which was observed in two cases in this study, can be a very mild phenotype of meningomyelocele, and urinary tract infection is frequently associated with meningomyelocele. 39 A variety of genes, including the folate receptor and folate carrier genes, may be associated with meningomyelocele.…”

Section: Discussionsupporting

confidence: 54%

Molar root-incisor malformation: considerations of diverse developmental and etiologic factors

Wright¹,

Curran²,

Kim

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Section: Discussionsupporting

confidence: 54%

Molar root-incisor malformation: considerations of diverse developmental and etiologic factors

Wright¹,

Curran²,

Kim

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Four of the proteins expressed in follicle cells that could not be confirmed by scRNA-seq (EBLN2, LEKR1, METTL24, and ZNF582) were identified also in our previous study. It is noteworthy that genetic variants of LEKR1 have been linked to low birth weight , as well as epithelial ovarian cancer, highlighting this protein as an immensely intriguing candidate warranting further comprehensive investigations.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomics and Spatial Proteomics for Discovery and Validation of Missing Proteins in the Human Ovary

Méar,

Hao,

Hikmet

et al. 2023

J. Proteome Res.

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Efforts to understand the complexities of human biology encompass multidimensional aspects, with proteins emerging as crucial components. However, studying the human ovary introduces unique challenges due to its complex dynamics and changes over a lifetime, varied cellular composition, and limited sample access. Here, four new RNA-seq samples of ovarian cortex spanning ages of 7 to 32 were sequenced and added to the existing data in the Human Protein Atlas (HPA) database , opening the doors to unique possibilities for exploration of oocyte-specific proteins. Based on transcriptomics analysis of the four new tissue samples representing both prepubertal girls and women of fertile age, we selected 20 protein candidates that lacked previous evidence at the protein level, so-called “missing proteins” (MPs). The proteins were validated using high-resolution antibody-based profiling and single-cell transcriptomics. Fourteen proteins exhibited consistent single-cell expression patterns in oocytes and granulosa cells, confirming their presence in the ovary and suggesting that these proteins play important roles in ovarian function, thus proposing that these 14 proteins should no longer be classified as MPs. This research significantly advances the understanding of MPs, unearthing fresh avenues for prospective exploration. By integrating innovative methodologies and leveraging the wealth of data in the HPA database, these insights contribute to refining our understanding of protein roles within the human ovary and opening the doors for further investigations into missing proteins and human reproduction.

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“…Sacral fractures are rare injuries that usually result from a significant trauma 8,17 or occur in the setting of sacral insufficiency secondary to osteoporosis. 23 However, on rare occasions they can result from minimal trauma.…”

Section: Discussionmentioning

confidence: 99%

“…8,11,18 Also, given that no meningocele was evident after treatment with lumbar drainage, it is unlikely that a meningocele was present before the injury, although we cannot entirely exclude that possibility. Nevertheless, if in fact our patient had a ruptured sacral cyst, conservative management with lumbar drainage treated the associated symptoms, thereby eliminating the need for surgical repair.…”

Section: 10mentioning

confidence: 94%

Anterior sacral pseudomeningocele following minimal trauma

Cools¹,

Al-Holou²,

Stetler³

et al. 2013

SPI

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Sacral fractures are rare and seldom result in formation of a sacral pseudomeningocele. Treatment of these pseudomeningoceles usually consists of conservative management with flat bedrest or open operative management. The authors describe the case of a 55-year-old woman with an anterior sacral pseudomeningocele that was successfully treated using a lumbar drain for temporary continuous CSF drainage. The patient first presented to an outside institution several days after sacral trauma from an ice skating fall. Initial symptoms included throbbing headaches relieved by lying flat. Head and cervical spine CT demonstrated no abnormality. As symptoms worsened, she presented to another institution where MRI of the lumbar spine indicated sacral fracture with pseudomeningocele. The patient subsequently transferred to the authors' facility, where symptoms included headaches and occasional mild sacral pain. Given her headaches and the authors' concern for CSF leak, another head CT scan was performed. This revealed no subdural hematoma or other abnormality. A subsequent CT myelogram revealed an anterior sacral pseudomeningocele at S3–4 with an anterior irregular linear filling defect, likely representing torn dura. Treatment included placement of a lumbar drain (10 ml/hr) and flat bedrest. Resolution of the CSF leak occurred on postprocedure Day 9. At the 4-week follow-up visit, the patient had no clinical symptoms of CSF leak and no neurological complaints. To our knowledge, this is the first description of temporary continuous CSF drainage used to treat a posttraumatic sacral pseudomeningocele. This technique may reduce the need for potentially complicated surgical repair of sacral fractures associated with CSF leak in select patients.

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Purulent meningitis due to spontaneous anterior sacral meningocele perforation. Case report

Abstract: A 36 year old woman with anterior sacral meningocele developed a purulent meningitis secondary to the rupture of the meningeal sac into the rectum. The value of neuroradialogical studies, especially CT, is emphasized.

Cited by 9 publications

References 7 publications

Molar root-incisor malformation: considerations of diverse developmental and etiologic factors

Molar root-incisor malformation: considerations of diverse developmental and etiologic factors

Transcriptomics and Spatial Proteomics for Discovery and Validation of Missing Proteins in the Human Ovary

Anterior sacral pseudomeningocele following minimal trauma

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