Pursuing Sinus Rhythm in Patients With Persistent Atrial Fibrillation

Impact of weight loss on ablation outcome in obese patients with longstanding persistent atrial fibrillation

“…Of the three, structural remodeling including cellular hypertrophy and diffuse and patchy interstitial fibrosis is the main mechanism responsible for disease progression in AF and in all likelihood it is more enduring and less reversible compared to electrical remodeling . The extent to which structural remodeling is reversible, and the optimal timing and tools for clinical intervention, still remain poorly defined …”

Atrial fibrillation ablation: contemporary practice and future potential

“…The progression of AF is such that more than 50% of patients with paroxysmal AF at presentation will progress to persistent AF despite pharmacological therapy 17. To support an earlier ablation strategy, it is imperative to prove that AF ablation attenuates the excess mortality associated with AF 18.…”