Purple sweet potato anthocyanin attenuates fat-induced mortality in Drosophila melanogaster

Wang, Lijun; Li, Yuk Man; Lei, Lin; Liu, Yuwei; Wang, Xiaobo; Ying, Ka; Zhang, Chengnan; Hui, Zhu; Zhao, Yimin; Chen, Zhenyu

doi:10.1016/j.exger.2016.06.006

Cited by 33 publications

(15 citation statements)

References 35 publications

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“…Wang et al. (2016) found a positive effect of 5 and 10 mg/ml PSPE on obesity‐induced mortality in a study carried out in D. melanogaster . The experimental diets were prepared by adding 0.5, 2.0, 5.0, 8.0, or 10.0 mg PSPE powder to the control diet per milliliter.…”

Section: Methodsmentioning

confidence: 99%

“…An in vivo study carried out in mice has found that PSPE exhibited memory enhancing effects and prevented decline in neural function, which may associate with its antioxidant properties (Cho et al., 2003). Meanwhile, many researches indicated that PSPE played an important role in preventing diseases, such as colorectal cancer and cardiovascular diseases (Lim et al., 2013; Wang et al., 2016). Furthermore, purple sweet potato color prevented the release of pro‐inflammatory factors by increasing autophagy level, thereby inhibiting endothelial cell senescence and maintaining intracellular stability (Sun et al., 2019), malondialdehyde (MDA) and ROS content, and enhancing autophagy activity in hippocampus of high‐fat‐feeding mice (Zhuang et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

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Purple sweet potato extract maintains intestinal homeostasis and extend lifespan through increasing autophagy in female Drosophila melanogaster

et al. 2021

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Purple sweet potatoes extract (PSPE) have been used as a natural food antioxidant with high anthocyanin concentrations. Research investigated the lifespan and the mechanisms of PSPE on female Drosophila melanogaster. Supplementation of PSPE extended the lifespan by 16.3% and had a protective effect on injury by oxidative stress. PSPE treatment enhanced the endogenous antioxidant enzyme activity and reduced malondialdehyde (MDA) content. Furthermore, PSPE significantly up‐regulated foxo‐related genes, inhibited mTOR mRNA expression, and activated autophagy to maintain intestinal homeostasis. Meanwhile, PSPE improved intestinal barrier dysfunction by 22.86%, decelerated the abnormal proliferation rate of intestinal stem cell (ISCs) by 23.77%, and improved intestinal integrity in geriatric D. melanogaster. In conclusion, PSPE may maintain intestinal homeostasis, and improve the antioxidant and stress resistance capacity through the insulin and rapamycin pathway, thereby extending the lifespan. Therefore, it provides active support to the development and application of PSPE in functional food. Practical applications In recent years, with the increase of age, age‐related complications have generally increased and seriously affected people’s healthy life. Purple sweet potato is a nutrient‐rich substance, which not only has a unique color but also contains rich anthocyanins, so it has many potential biological and pharmacological functions. Our results showed that the PSPE had a good effect of maintaining the intestinal homeostasis of the older adult, and provided a favorable theoretical basis for the development of PSPE functional products and scientific academic research.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Purple sweet potato extract maintains intestinal homeostasis and extend lifespan through increasing autophagy in female Drosophila melanogaster

et al. 2021

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“…The synthesis of these enzymes is considered to be an important regulator of the stress response in animals. As an endogenous oxidation defense system, the over-expression of SOD and CAT genes increases the longevity of D. melanogaster ( 33 – 36 ). Thus, the induction of Hsp70 and the generation of antioxidant enzymes are potential regulatory factors for the improvement of heat tolerance under thermal stress.…”

Section: Introductionmentioning

confidence: 99%

Hsian-Tsao (Mesona chinensis Benth.) Extract Improves the Thermal Tolerance of Drosophila melanogaster

Huang

Cai

et al. 2022

Front. Nutr.

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Global warming has prompted scientific communities to consider how to alleviate thermal stress in humans and animals. The present study assessed the supplementation of hsian-tsao extract (HTE) on thermal stress in Drosophila melanogaster and preliminarily explicated its possible physiological and molecular mechanisms. Our results indicated that the lethal time for 50% of female flies fed on HTE was significantly longer than that of male flies at the same heat stress temperature. Under thermal stress, the survival time of females was remarkably increased in the HTE addition groups compared to the non-addition group. Thermal hardening by acute exposure to 36°C for 30 min (9:00 to 9:30 a.m.) every day could significantly prolong the longevity of females. Without thermal hardening, HTE increased the antioxidant capacity of females under heat stress, accompanied by an increment of catalase (CAT) activity, and the inhibition for hydroxyl radicals (OH⋅) and superoxide anions (⋅O2–). Superoxide dismutase (SOD) activity and the inhibition for ⋅O2– was significantly affected by thermal hardening in the non-HTE addition groups, and significant differences were shown in CAT and SOD activities, and the inhibition for ⋅O2– among groups with thermal hardening. After heat exposure, heat shock protein 70 (Hsp70) was only up-regulated in the group with high levels of added HTE compared with the group without and this was similar in the thermal hardening group. It was concluded that the heat stress-relieving ability of HTE might be partly due to the enhancement of enzymatic activities of SOD and CAT, and the inhibition for OH⋅ and ⋅O2–. However, the expression levels of Hsp70 were not well related to thermal tolerance or heat survival.

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“…Altitude, which has an effect similar to latitude, seems to be positively correlated to the anthocyanin content in S. nigra fruits (Senica et al, 2017). Anthocyanins being a source of antioxidants, their consumption has been proven beneficial for Drosophila melanogaster (Valenza et al, 2018;Wang et al, 2016). A higher number of reddish-black fruits as well as higher contents of anthocyanins could therefore mean resources of better quality for D. suzukii and explain the higher infestation of elderberry at high latitudes.…”

Section: Landscape Compositionmentioning

confidence: 99%

Macroecological patterns of fruit infestation rates by the invasive fly Drosophila suzukii in the wild reservoir host plant Sambucus nigra

Ulmer

Couty

Eslin

et al. 2022

Agri and Forest Entomology

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1. The invasive pest Drosophila suzukii is a fruit fly native to Asia that infests a wide variety of fruits. Wild plant species are major reservoirs for D. suzukii populations but their infestation rates vary greatly among geographical areas.2. We aimed at disentangling the relative roles of macroclimatic, landscape and local factors in the rate of D. suzukii infestation of elderberry fruits (Sambucus nigra), a major wild host plant in Europe.3. We collected elderberry fruits across 215 sites distributed in 13 regions from North to South of France. We counted the number of emerging D. suzukii adults and

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Purple sweet potato anthocyanin attenuates fat-induced mortality in Drosophila melanogaster

Cited by 33 publications

References 35 publications

Purple sweet potato extract maintains intestinal homeostasis and extend lifespan through increasing autophagy in female Drosophila melanogaster

Purple sweet potato extract maintains intestinal homeostasis and extend lifespan through increasing autophagy in female Drosophila melanogaster

Hsian-Tsao (Mesona chinensis Benth.) Extract Improves the Thermal Tolerance of Drosophila melanogaster

Macroecological patterns of fruit infestation rates by the invasive fly Drosophila suzukii in the wild reservoir host plant Sambucus nigra

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