Purple Icodextrin: Turkish Delight?

When the color of peritoneal dialysis effluent can be used as a diagnostic tool

“…90,91 After careful investigation, it turned out that this phenomenon was secondary to a chemical reaction between the iodine present in the disconnect cap and an icodextrin solution manufactured in Turkey which differed from that produced by other manufacturers by its greater fraction of large polymers. 92 No clinical significance was noted by the authors. Since 2011, this particular icodextrin has not been available.…”

“…Between 2001 and 2011, a transient purple discoloration was noted by several patients and clinicians in Europe of the very early drainage phase of a 7.5% icodextrin solution, a starch‐derived glucose polymer . After careful investigation, it turned out that this phenomenon was secondary to a chemical reaction between the iodine present in the disconnect cap and an icodextrin solution manufactured in Turkey which differed from that produced by other manufacturers by its greater fraction of large polymers . No clinical significance was noted by the authors.…”

Absence of Post-Transplantation Encapsulating Peritoneal Sclerosis after Relatively Short Exposure to Peritoneal Dialysis: Prospective Analysis Using Repeated Abdominal Ct Scanning

“…That icodextrin per se has no profibrotic properties (44) may explain the current safe use of icodextrin-containing dialysate, also in our cohort. Interestingly, unexpected differences in the specific composition of dialysate may also occur (45). Consequently, changes in dialysate composition, perhaps sometimes being transient and even remaining unnoticed, could play a role in altering the incidence of EPS.…”