Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Luo, Junqiu; Chen, Shuai; Mao, Xiangbing; He, Jun; Yu, Bing; Cheng, Long; Zeng, Dafu

doi:10.3390/ani9090602

Cited by 20 publications

(28 citation statements)

References 31 publications

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“…In addition, we did not find any significant differences in growth performance after 21 d feeding period between the olaquindox and the control group, however, pigs fed with β-glucan had greater BW and ADG than pigs in other groups. These results showed that β-glucan could improve the growth rate of weaned pigs, which was consistent with the previous study on LPS-challenged pigs ( Luo et al., 2019a ). However, no significant difference was found on growth performance between the olaquindox and the control group; the reason may be attributed to the feeding time (21 d) or dosage of the olaquindox in the present study.…”

Section: Discussionsupporting

confidence: 93%

A water-soluble β-glucan improves growth performance by altering gut microbiome and health in weaned pigs

Xue

Liu

et al. 2021

Animal Nutrition

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Beta-glucan has been shown to have a beneficial effect on gastrointestinal health. This experiment was conducted to investigate the effects of β-glucan isolated from Agrobacterium sp. ZX09 on growth performance and intestinal health of weaning pigs. A total of 108 weaned pigs (21 d of age; 6.05 ± 0.36 kg) were randomly divided into 3 groups (6 pens/group; 6 pigs/pen), and the groups were each treated with the following diets: 1) basal diet, 2) basal diet supplemented with 20 mg/kg olaquindox, 3) basal diet supplemented with 200 mg/kg β-glucan, for 21 d. Compared with the control group, pigs fed with 200 mg/kg β-glucan had greaterBW, average daily gain and duodenal villus height to crypt depth ratio ( P < 0.05). Olaquindox increased the duodenal or jejunal villus height of pigs compared with β-glucan. Compared with the control group, β-glucan tended to increase the occludin mRNA expression in the jejunum (0.05 < P < 0.10). Beta-glucan enriched the beneficial microbiota in the ileum of pigs ( P < 0.05). In conclusion, β-glucan may promote growth performance by improving intestinal health and increasing beneficial microbiota of weaned pigs. The study results will provide valuable theoretical guidance for the utilization of β-glucan in weaned pigs.

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Section: Discussionsupporting

confidence: 93%

A water-soluble β-glucan improves growth performance by altering gut microbiome and health in weaned pigs

Xue

Liu

et al. 2021

Animal Nutrition

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“…The villus height, crypt depth and villus height/ crypt depth values of the small intestine are important indicators of intestinal development and function. The increased crypt depth, lower villus height and villus height/crypt depth values in the small intestines of the LPS-stimulated group compared to the CON group were in accordance with recent researches Luo et al 2019). Moreover, previous research has demonstrated that feeding SB increased the jejunal villus height and villus height/ crypt depth (Wang et al 2018).…”

Section: Discussionsupporting

confidence: 90%

Dietary sodium butyrate protects lipopolysaccharide-induced inflammatory response in lambs through inhibiting TLR4/NF-κB signalling pathway

Wang

Chen

Zuo

et al. 2021

Italian Journal of Animal Science

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This study evaluated the effects of dietary coated sodium butyrate (CSB) on lipopolysaccharide (LPS)-induced inflammatory response in weaned lambs. A basal diet was supplemented with CSB at 0, 2 or 3 g/kg feed for 28 days and/or intraperitoneally injected with 100 lg/kg BW Escherichia coli LPS (0 g/kg CSB, 0 g/kg CSB and LPS, 2 g/kg CSB and LPS, 3 g/kg CSB and LPS). The results showed that CSB supplementation conferred significant protective effects against LPS-induced inflammatory response by reducing in the levels of D-lactate (DLA), diamine oxidase (DAO), inflammatory cytokines (TNF-a, IL-1b and IL-8) in the serum and upregulated expression of tight junction proteins (claudin-3, ZO-1 and occludin) in the ileum. Meanwhile, CSB pre-treatment significantly suppressed LPS-induced TLR4/NF-jB signalling pathway mRNA expression (MyD88, TLR4, NF-jB, IL-6 and IL-1b) and down-regulated TLR4/NF-jB signalling pathway protein expression (MyD88, TLR4, NF-jB p65 and p-NF-jB p65). Furthermore, dietary CSB supplementation improved intestinal morphology. Lastly, bacterial 16S rRNA gene sequencing indicated that CSB could alter intestinal microbiota composition at genus levels. Taken together, our results indicate CSB could maintain intestinal health, improve intestinal morphology, modulate the microbial community and decrease LPS-induced inflammatory response in lambs.

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“…The lactate and SCFA are recognized as beneficial metabolites of polysaccharides fermentation. β -glucan has been proved to have the potential to produce lactate, which could not only increase the content of lactate in the mucus of piglets but also provoke the growth of Bifidobacterium and the emergence of a balanced microbiota [ 37 ]. Besides, β -glucan oligosaccharides showed great lactate-producing capacity [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Fermentation Characteristics and Fiber-Degrading Enzyme Kinetics of Cellulose, Arabinoxylan, β-Glucan and Glucomannan by Pig Fecal Microbiota

Bai

Zhou

et al. 2021

Microorganisms

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Non-digestible polysaccharides are of great significance to human and animal intestinal health. Cellulose, arabinoxylan, β−glucan and glucomannan were selected in the present study to investigate the fermentation characteristics and fiber-degrading enzyme kinetics by inoculating pig fecal microbiota in vitro. Our results showed that fermentation of arabinoxylan and β-glucan produced the highest amount of acetate and lactate, respectively. The abundance of Prevotella_9 was the highest in β-glucan group and positively correlated with lactate and acetate. Glucomannan fermentation produced the highest amount of butyrate, and the abundance of Lachnospiraceae_XPB_1014_group and Bacteroides were the lowest. A significant negative correlation was found between Lachnospiraceae_XPB_1014_group, Bacteroides and butyrate. Exo-β-1,4-xylanase had the highest activity at 24 h during arabinoxylan fermentation. The activity of β-glucosidase and β-mannosidase at 36 h were higher than those at 15 h in the glucomannan group. The abundance of Prevotella_9 was positively correlated with β-glucosidase while Lachnospiraceae_XPB_1014_group and Bacteroides were negatively correlated with β-xylosidase. Our findings demonstrated the β-glucan and arabinoxylan promote proliferation of Prevotella_9, with the preference to secret β-glucosidase, β-mannosidase and the potential to produce lactate and acetate. Butyrate production can be improved by inhibiting the proliferation of Lachnospiraceae_XPB_1014_group and Bacteroides, which have the lack of potential to secret β-xylosidase.

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Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Cited by 20 publications

References 31 publications

A water-soluble β-glucan improves growth performance by altering gut microbiome and health in weaned pigs

A water-soluble β-glucan improves growth performance by altering gut microbiome and health in weaned pigs

Dietary sodium butyrate protects lipopolysaccharide-induced inflammatory response in lambs through inhibiting TLR4/NF-κB signalling pathway

In Vitro Fermentation Characteristics and Fiber-Degrading Enzyme Kinetics of Cellulose, Arabinoxylan, β-Glucan and Glucomannan by Pig Fecal Microbiota

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