Purification Strategies in Olefin Metathesis

Removable Water-Soluble Olefin Metathesis Catalyst via Host–Guest Interaction

“…Complete removal of homogeneous organometallic catalysts is an important issue in modern chemistry. − There are two major removal methods of well-defined organometallic catalysts: (1) solid-supported heterogeneous systems and (2) homogeneous methods utilizing modified catalyst ligands . Homogeneous catalysts typically display many advantages over heterogeneous catalysts such as rapid reaction rate, facile characterization, higher reactivity, and chemoselectivity .…”

“…In spite of the importance of Ru-based olefin metathesis catalysts, the complete removal of Ru residue from the resulting products still represents a major challenge for their practical application because the metal residue causes undesirable electronic properties, colorization, and toxicity of pharmaceutical products . Specifically, the maximum amount of Ru permissible in pharmaceutical products is less than 10 ppm. , Herein, we report a new NHC ligand and the resulting Ru-based olefin metathesis catalyst designed for the removal of Ru catalyst residues via host–guest interactions and phase selective solubilities of the new catalyst.…”

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes

“…An important aspect in the industrial valorization of Ru complexes is the removal of ruthenium residues, mandatory in areas where the level of this heavy metal in the final products (pharmaceuticals, specialty polymers designed for food supplies, and biomedical, textile or electronic applications) could be problematic for human health [329]. Overall, the high potential and versatility of the Ru complexes attest to the importance they assume in chemistry and other scientific and technical areas and undoubtedly ensure the emergence, in the near future, of further developments serving mankind.…”

Oligo(ethylene glycol) Length Effect of Water-Soluble Ru-Based Olefin Metathesis Catalysts on Reactivity and Removability

“…Several solutions to the Ru contamination problem in metathesis products have been reported by using catalyst modifications , and new purification protocols. , In catalyst modification methods, there have been two main approaches: (1) solid-supported heterogeneous catalysts and (2) homogeneous catalysts that possess modified ligand structure . Homogeneous catalysis has shown more benefits for chemical reaction rate, reactivity, and chemoselectivity than heterogeneous methods.…”