Purification of human IgG4 subclass with allergen-specific blocking activity

Lambin, P.; Bouzoumou, A.; Murrieta, Maricela Urías; Debbia, Martine; Rouger, Philippe; Leynadier, F.; Levy, David A.

doi:10.1016/0022-1759(94)90134-1

Cited by 7 publications

(7 citation statements)

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“…The functional role of allergen‐specific inhibitory IgG 1 and IgG 4 antibodies has been demonstrated in other studies. Using monoclonal Bet v 1–specific IgG 1 and polyclonal IgG 1 and IgG 4 antibodies, these antibodies inhibited basophil histamine release in SIT‐treated patients (9, 26, 27). The possible mechanisms of how grass pollen–specific IgG 1 and IgG 4 antibody subclasses contribute towards desensitization are not very well understood.…”

Section: Discussionmentioning

confidence: 99%

Functional rather than immunoreactive levels of IgG₄ correlate closely with clinical response to grass pollen immunotherapy

Shamji

Ljørring

Francis

et al. 2011

Allergy

261

234

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Section: Discussionmentioning

confidence: 99%

Functional rather than immunoreactive levels of IgG₄ correlate closely with clinical response to grass pollen immunotherapy

Shamji

Ljørring

Francis

et al. 2011

Allergy

261

234

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“…Although hampered by the lack of pure allergens for the investigation of blocking antibodies, attempts have been made to measure blocking antibody responses (18–20). IgG antibody measurement performed with allergen extracts cannot discriminate between IgG antibodies specific for non‐allergenic components and allergens.…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis

Noh

Ahn²,

Cho

et al. 2007

Pediatric Allergy Immunology

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Food is closely associated with the pathogenesis of atopic dermatitis. Food allergy is usually mediated by IgE antibody to specific food proteins and determination of specific IgE antibody is the basis of the common diagnostic test for food allergy. IgG4 have been reported as blocking antibody and the protective effects of blocking antibody may be clear in inhalant allergy. However, the role of IgG4 in food allergy is still a matter of debate. In this study, the clinical significance of food allergen-specific IgE/IgG4 in atopic dermatitis was investigated and compared with that of IgE. A total of 97 patients who fulfilled the diagnostic criteria for atopic dermatitis participated in this study. Skin prick test and allergy patch test were performed. Specific IgE and IgG4 concentration were measured using allergy protein chip, 'AllergyChip'. Double blinded placebo controlled food challenge test (DBPCFC) was performed for the diagnosis of allergy to milk, egg white, wheat, and soybean. DBPCFCs for milk, egg white, soybean, and wheat were performed. The positive rates were 31.7% (19/60) in milk, 36.7% (18/49) in egg white, 30.4% (7/23) in soybean, and 34.8% (8/23) in wheat. Mean IgE/IgG4 levels in DBPCFC (+) subjects is higher than those in DBPCFC (-) subjects in all food items studied. Of them, there were significantly different between two groups in egg white and wheat (Egg white in DBPCFC (+) vs. (-): 0.4 +/- 0.3 vs. 0.2 +/- 0.2, wheat in DBPCFC (+) vs. (-): 1.2 +/- 1.2 vs. 0.3 +/- 0.3, p < 0.05). Allergen-specific IgE/IgG4 may provide one of the clues to understand the mechanism of food allergy in atopic dermatitis. The present study suggests that protein microarray can be one of the useful methods to assess ongoing status of allergic diseases.

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“…It has been demonstrated by several investigators that SIT‐induced IgG in individual patients can inhibit histamine release (HR) from basophils in vitro [20–23]. Similarly, blocking of HR has been shown with monoclonal human Bet v 1‐specific IgG1 [24].…”

Section: Introductionmentioning

confidence: 99%

A double‐blind placebo‐controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation

Würtzen

Lund

et al. 2008

Clin Experimental Allergy

102

107

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Purification of human IgG4 subclass with allergen-specific blocking activity

Cited by 7 publications

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Functional rather than immunoreactive levels of IgG₄ correlate closely with clinical response to grass pollen immunotherapy

Functional rather than immunoreactive levels of IgG₄ correlate closely with clinical response to grass pollen immunotherapy

The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis

A double‐blind placebo‐controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation

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Purification of human IgG4 subclass with allergen-specific blocking activity

Cited by 7 publications

References 0 publications

Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy

Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy

The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis

A double‐blind placebo‐controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation

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Functional rather than immunoreactive levels of IgG₄ correlate closely with clinical response to grass pollen immunotherapy

Functional rather than immunoreactive levels of IgG₄ correlate closely with clinical response to grass pollen immunotherapy