Purification of a N-Methyltransferase.

Gustafsson, Arne; Forshell, Gustaf Plym; Forsén, Sture; Andersen, Inger Grete Krogh; Munch‐Petersen, Jon

doi:10.3891/acta.chem.scand.17-0541

Cited by 25 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding* of an increased histamine concentration in the hypothalamus after chlorpromazine (Table 2) agrees with the results of Adam & Hye (1964) in cat hypothalamus, and of Green & Erickson (1964) in rat whole brain. Chlorpromazine has been reported to inhibit the formation of methylhistamine in vitro (Brown et al, 1959;Gustafsson & Forshell, 1963) and in vivo (White, 1961;.…”

Section: Discussionmentioning

confidence: 99%

Histamine and Methylhistamine in Cat Brain and Other Tissues

White

1966

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Histamine and Methylhistamine in Cat Brain and Other Tissues

White

1966

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

“…This rise could be due to inhibition of histamine catabolism by the monoamines formed or their catabolic products; 5-HT is known to inhibit methylation of histamine in vitro (Brown et al, 1959;Gustafsson & Forshell, 1963) and in vivo . These findings may imply a differentiation between the mid-brain and other regions in the metabolism of histamine.…”

Section: Discussionmentioning

confidence: 99%

Concentration of histamine in different parts of the brain and hypophysis of rabbit: effect of treatment with histidine, certain other amino acids and histamine

Abou

Adam

Stephen

1973

British J Pharmacology

View full text Add to dashboard Cite

4. In conscious rabbits, intravenous infusion of histidine in the dose range 62 to 1,500 mg/kg, raised significantly (P<0-01) the concentration of histamine in all regions of the brain examined, the pattern of distribution remaining unchanged. The largest increases occurred in the mid brain (90 to 320%) and in the hypothalamus (50 to 250%); in these areas the higher doses produced higher concentrations. Elsewhere in the brain the concentration rose in response to the lowest dose of histidine, but was not increased when higher doses were given. Concentrations in the anterior lobe of the hypophysis were unaltered. 5. The infusion of histidine, unlike that of amino acid precursors, of the monoamines, produced no obvious disturbance in the animals. 6. The rise in brain histamine after dosage with histidine persisted for several hours, depending on the dose; with 500 mg/kg, the rise was virtually unchanged after 16 hours. 7. Histamine (5 mg/kg by intravenous infusion) raised the concentration of histamine in the hypophysis but not in the brain.8. After the infusion of DOPA, a-methyldopa or 5-hydroxytryptophan, the histamine concentration rose in the mid-brain but not in other parts of the brain.9. These amino acids, when infused singly with histidine, did not interfere with the histidine-induced rise of brain histamine.

show abstract

“…Since chlorpromazine inhibits the methylation of histamine in vitro (Brown et al, 1959); Gustaffson & Forshell, 1963) and in vivo (White, 1961 ;Snyder & Axelrod, 1964), it may have acted in this way to increase the brain histamine. By contrast, treatment with chlorpromazine has no apparent effect on the concentration of monoamines in brain (Gey & Pletscher, 1961).…”

Section: Effect Of Drugsmentioning

confidence: 99%