Purification, identification and hypolipidemic activities of three novel hypolipidemic peptides from tea protein

Efficient screening of pancreatic lipase inhibitors from Rheum palmatum by affinity ultrafiltration–high‐performance liquid chromatography combined with high‐resolution inhibition profiling

“…Molecular docking has been widely used in the study of the interaction mechanism between enzymes and ligands and the prediction of enzyme inhibitory activity of ligands 4,35 …”

“…Molecular docking has been widely used in the study of the interaction mechanism between enzymes and ligands and the prediction of enzyme inhibitory activity of ligands. 4,35 Molecular docking studies were conducted on the potentially bioactive compounds obtained through the two screening methods. The active pocket amino acid residues reported in IETH mainly include Phe78, Ile79, Asp80, Trp86, Tyr115, His152, Ser153, Phe216, Arg257, His264, and Leu265.…”

Isolation and identification of an α-glucosidase inhibitory peptide from extruded soybean protein and its hypoglycemic activity in T2DM mice

“…12,44 Hydrophobic peptides can bind to bile salts to reduce cholesterol levels and facilitate their hypolipidemic ability. 45 In addition, some low molecular weight, hydrophobic peptides exhibit an antioxidant effect and high digestive stability. 46…”

“…12,44 Hydrophobic peptides can bind to bile salts to reduce cholesterol levels and facilitate their hypolipidemic ability. 45 In addition, some low molecular weight, hydrophobic peptides exhibit an antioxidant effect and high digestive stability. 46 Taken together, the results demonstrated the hypoglycemic activity of ESPro in vitro and in vivo, but there are still some limitations.…”

Simultaneous effect of different chromatographic conditions on the chromatographic retention of pentapeptide derivatives (HGRFG and NPNPT)

“…The oligopeptides produced by the enzymatic hydrolysis of animal proteins have been reported to exhibit outstanding hypotensive effects by inhibiting the angiotensin-I converting enzyme ( Abdelhedi et al, 2017 ; Qiao et al, 2022 ). Moreover, the oligopeptides extracted from tea and brewer’s spent grain had excellent hypolipidemic activities ( Ferreira et al, 2022 ; Ye et al, 2023 ), and the oligopeptides isolated from Siberian sturgeon cartilage could treat chronic diseases caused by oxidative stress ( Sheng et al, 2022 ). More importantly, oligopeptides exhibit great prospects for clinical application due to their high degree of affinity and specificity and easy absorption ( Zhang et al, 2020 ; Sitkov et al, 2021 ).…”