Efficient screening of pancreatic lipase inhibitors from Rheum palmatum by affinity ultrafiltration–high‐performance liquid chromatography combined with high‐resolution inhibition profiling
Sihua Quan,
Mengyi Wen,
Ping Xu
et al.
Abstract:IntroductionPancreatic lipase is one of the most important key targets in the treatment of obesity. Inhibition of pancreatic lipase can effectively reduce lipid absorption and treat obesity and other related metabolic disorders.ObjectivesThe goal of this study is the efficient screening of pancreatic lipase inhibitors in the root and rhizome of Rheum palmatum using affinity ultrafiltration–high‐performance liquid chromatography (AUF‐HPLC) combined with high‐resolution inhibition profiling (HRIP).MethodsPotenti… Show more
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