Pure Small Cell Carcinoma of the Prostate: A Case Report and Literature Review

Capizzello, Antonio; Peponi, Evangelia; Simou, Nafsika; Ntaskagiannis, Dimitrios; Tasiou, Ifigenia; Kamina, Sevasti; Tsekeris, P.

doi:10.1159/000324717

Cited by 16 publications

(21 citation statements)

References 15 publications

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“…Prostat küçük hücreli karsinomlarının bugüne kadar orijini belirlenememiştir (5,6). Bazal progenitor hücreler-le benzerliklerinin olması (p63 ve c-kit pozitifliği) multi potansiyel progenitörlerin transformasyonunu akla getirmektedir.…”

Section: Discussionunclassified

“…Adenokarsinom birlikteliği durumunda hormonal tedavi (orşiektomi, gonadotropin salgılatıcı agonistler veya antiandrojenler) kullanılabilir (5). Saf küçük hücreli karsinomlarda, prostatik nöroendokrin hücreler androjen reseptörü içermediği için hormonal tedavi öne-rilmez (4,5). Akciğerin küçük hücreli karsinomlarında kullanılan etoposid, sisplatin ve vinkristin kemoterapötik olarak uygulanabilir (7).…”

Section: Resim 6 Bilgisayarlı Tomografide Her Iki Böbrekte Pelvikaliunclassified

“…Bazı olgularda ilk bulgu ağrı ve paraneoplastik sendromlar olabilir (4). Prostatik malign nöroendokrin hücreler ektopik peptitler, adrenokortikotropik hormon (ACTH) ve kalsitonin üretmeye eğilimlidir, bunlar sıklıkla serumda tespit edilir (5). Bu tümörler karaciğer dahil viseral organlara, akciğerlere, kemik, santral sinir sistemi, perikard ve bölgesel pelvik lenf nodlarına metastaz potansiyeline sahiptir (3,5).…”

Section: Introductionunclassified

“…Bu tümörler karaciğer dahil viseral organlara, akciğerlere, kemik, santral sinir sistemi, perikard ve bölgesel pelvik lenf nodlarına metastaz potansiyeline sahiptir (3,5). Lokal tümör infiltrasyonu ile rektum ve mesane tutulumu oluşabilir (5). Prognoz kötüdür, literatürde tam remisyon başarılabilen birkaç olgu bildirilmiştir (4).…”

Section: Introductionunclassified

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Small cell carcinoma of the prostate in differential diagnosis - A case report

Durmaz¹,

Kılınç²,

Buldu³

et al. 2017

Eur J Ther

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ÖZEkstrapulmoner küçük hücreli karsinomlar nadir, agresif seyirli ve sık metastaz yapan malign neoplazilerdir. Bu tümörler başlıca üst solunum yolu, özefagus ve ürogenital sistemde ortaya çıkar. Küçük hücreli prostat karsinomları tüm prostat kanserleri içinde %1'den daha az orandadır. Bunlar, daha önceden prostatik adenokarsinom tanısı almış ve androjen deprivasyon tedavisi uygulanan hastalarda da gelişebilir. Prostat kanserinde nöroendokrin diferansiasyonu yakalamak ve saf küçük hücreli karsinomu kötü diferansiye asiner adenokarsinomdan ayırt etmek önemlidir. Bu yazıda, 3 yıl önce prostat adenokarsinomu tanısı almış, androjen deprivasyon tedavisi uygulanmış küçük hücreli prostat karsinomu olgusu, ayırıcı tanı kriterleri, önemli histopatolojik ve immünohistokimyasal özellikleri, tedavi ve prognozu açısından literatür bilgileri eşliğinde sunulmaktadır. Keywords: Ekstrapulmoner, küçük hücreli karsinom, prostat ABSTRACTExtrapulmonary small cell carcinomas are rare, aggressive malignant neoplasms with frequent metastases. These tumors mainly occur in the upper respiratory tract, esophagus and urogenital system. Small cell carcinomas of the prostate constitute less than 1% percentage of all prostate cancers. They can also develop in patients with previously diagnosed prostatic adenocarcinoma and treated with androgen deprivation therapy. It is important to detect neuroendocrine differentiation and distinguish pure small cell carcinoma from poorly differentiated acinar adenocarcinoma. In this article, a case of prostatic small cell carcinoma that applied to androgen deprivation therapy because of a former diagnosis of prostatic adenocarcinoma three years ago, is presented with associated differential diagnosis, major histopathologic and immunohistochemical features, treatment and the prognosis and literature knowledge.

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Section: Discussionunclassified

Section: Resim 6 Bilgisayarlı Tomografide Her Iki Böbrekte Pelvikaliunclassified

Section: Introductionunclassified

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Small cell carcinoma of the prostate in differential diagnosis - A case report

Durmaz¹,

Kılınç²,

Buldu³

et al. 2017

Eur J Ther

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“…In approximately 50% of the patients, pathological findings reveal adenocarcinomatous elements. [4] Pure small cell carcinoma of the prostate is an extremely rare occurrence, with clinical features unlike those of prostatic adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Pure small cell carcinoma of the prostate: case report

Ati̇lla¹,

Şahin²,

Bakırtaş³

et al. 2012

Turkish Journal of Urology

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Extrapulmonary small cell carcinoma arising in the prostate gland has been described in several case series and case reports. However, pure small cell carcinoma of the prostate is rare, and there are only a few reports in the literature describing the clinical features and management of this neoplasm. These tumors are highly aggressive and commonly manifest with visceral metastasis at the time of diagnosis. This report describes the diagnosis and management of a 73-year-old patient with small cell carcinoma of the prostate in light of the reviewed literature.

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Current trend of worsening prognosis of prostate small cell carcinoma: A population‐based study

et al. 2019

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Objective To determine the accurate age‐adjusted incidence of prostate small cell carcinoma (SCC), update the clinical and pathological characteristics, as well as survival data of prostate SCC from Surveillance, Epidemiology, and End Results (SEER) datasets. Methods A total of 260 patients with prostate SCC were selected from the SEER database of the National Cancer Institute between 2004 and 2015. Age‐adjusted incidence (AAI) rates, the observed and relative survival rates were evaluated over time by the SEER*Stat Software version 8.3.5. Overall survival (OS) rates that stratified by summary stage and treatment effects were evaluated by Kaplan‐Meier method. The significant differences were assessed in a log‐rank test. Univariate and multivariate cox hazard regression analysis were performed to determine independent predictors of OS. Results The incidence of prostate SCC has increased over time. The average age of prostate SCC patients was 70.25 years. More than 90% of tumors were poorly differentiated or undifferentiated. The majority of prostate SCC (77.7%) was at stage IV. 49% of patients had lymph node metastases and 68% of patients presented distant metastases (Compared with 60.5% of patients with distant metastases between 1973‐2003). Interestingly only 23.5% patients had high level PSA (>10 ng/mL). 58.8% of patients underwent chemotherapy, 25.4% of patients were treated by surgery, and 31.9% of patients were treated by radiotherapy. The observed survival rates of 1‐year, 2‐year, and 5‐year were 42.1%, 22.1%, and 12.5%, respectively (Compared with 47.9%, 27.5%, and 14.3%, respectively, between 1973 and 2003). Chemotherapy prolonged the OS of patients with regional (distant) metastases from 3 months (2 months) to 12 months (9 months). Multivariate cox regression analysis showed age, race, and stage were independent prognostic factors for prostate SCC patients. Conclusion Prostate SCC is a highly malignant cancer and our analysis of recent data has shown its incidence is increasing. Incidence rate of metastatic prostate SCC has increased and the survival rates have worsened in recent years. However, chemotherapy shows some survival benefit for prostate SCC patients with regional and distant metastasis over other treatment methods. Further work is needed to understand the reason prognosis of this type prostate cancer is worsening.

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Pure Small Cell Carcinoma of the Prostate: A Case Report and Literature Review

Cited by 16 publications

References 15 publications

Small cell carcinoma of the prostate in differential diagnosis - A case report

Small cell carcinoma of the prostate in differential diagnosis - A case report

Pure small cell carcinoma of the prostate: case report

Current trend of worsening prognosis of prostate small cell carcinoma: A population‐based study

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