Pure seminoma: A review and update

Abstract

Pure seminoma is a rare pathology of the young adult, often discovered in the early stages. Its prognosis is generally excellent and many therapeutic options are available, especially in stage I tumors. High cure rates can be achieved in several ways: standard treatment with radiotherapy is challenged by surveillance and chemotherapy. Toxicity issues and the patients' preferences should be considered when management decisions are made. This paper describes firstly the management of primary seminoma and its nodal involvement and, secondly, the various therapeutic options according to stage.

Distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) in the human testis and in testicular germ cell tumors

“…Testicular germ cell tumors are common in young men (Boujelbene et al ., ). Their prevalence is increasing steadily, although the underlying causes of such tumors are still poorly understood.…”

Metastatic seminoma presenting as flank pain

“…About 80% present with stage I disease, which is highly curable. 3 Our case is an unusual presentation of an incidental pure seminoma, with a pelvic lymph node metastasis causing hydronephrosis and no history of scrotal surgery. Other rare presentations of seminomas include cutaneous and perineal metastases, in addition to paraneoplastic syndromes including polycythaemia.…”

Classification of Testicular Tumors

“…Similar to IGCNU, seminoma cells express PLAP, CD117, SALL4, podoplanin, SOX17, and OCT3/4. Seminoma, 80 % of which are diagnosed at stage I, is highly sensitive to both radiotherapy and chemotherapy and, therefore, cure is an expected outcome in the majority of cases, even with metastatic disease at presentation [7]. The classical and the syncytiotrophoblastic types of seminoma behave similarly, although the syncytiotrophoblastic subtype is associated with increased serum beta HCG levels.…”