Pure Red-cell Aplasia in Marasmus and Kwashiorkor Treated with Riboflavine

Foy, Henry; Kondi, Athena; Macdougall, Lorna G.

doi:10.1136/bmj.1.5230.937

Cited by 49 publications

(23 citation statements)

References 16 publications

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“…Foy and Kondi reported a case of red cell aplasia that was believed to respond to riboflavin therapy (57). Foy, Kondi, and MacDougall recently have also reported red cell aplasia or hypoplasia in 9 of 23 cases of marasmus and kwashiorkor in Kenya (58). Five of these patients showed increases in hemoglobin and hematocrit, and 3 patients developed reticulocytosis after riboflavin administration.…”

Section: Discussionmentioning

confidence: 99%

The Rapid Induction of Human Riboflavin Deficiency with Galactoflavin *

Lane¹,

Alfrey²,

Mengel³

et al. 1964

J. Clin. Invest.

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Signs of riboflavin deficiency require many months to develop in patients placed on riboflavinrestricted diets (1-6). The demonstrations that riboflavin deficiency induced by dietary restriction or riboflavin antagonists resulted in regression of rodent tumors (7-13) prompted several efforts in this laboratory to produce riboflavin deficiency in patients with neoplastic disease (14, 15). Riboflavin antagonists were used in these studies with the objective of producing the deficiency state rapidly, since a regimen requiring many months of dietary restriction would not lend itself to therapeutic evaluation in patients with metastatic cancer. These earlier investigations did not result in the production of clinical evidences of riboflavin deficiency or in objective demonstrations of tumor regression. The administered riboflavin antagonists, selected on the basis of their effectiveness in rats, were shown to be metabolized differently in man. The most active of these agents against rat tumors, 6,7-dimethyl-9-(2'-acetoxyethyl) -isoalloxazine, was rapidly and almost completely hydrolyzed in man, although a significant amount of the absorbed drug was excreted unchanged by rats. With the objective of producing human riboflavin deficiency, an analog was sought that would be an effective riboflavin antagonist in rodents and would be metabolized similarly in rodents and in man.The present paper describes studies with 1O-Ddulcityl -7,8-dimethyl-isoalloxazine, galactoflavin,

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Section: Discussionmentioning

confidence: 99%

The Rapid Induction of Human Riboflavin Deficiency with Galactoflavin *

Lane¹,

Alfrey²,

Mengel³

et al. 1964

J. Clin. Invest.

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“…On the 36th day the reticulocyte count suddenly rose to 9.4% coincident with a small rise in haemoglobin. Foy et al (1961) had a similar patient with two hypoplastic phases.…”

Section: Methodsmentioning

confidence: 94%

“…He suggested that it was due to a toxic allergic reaction after toxins, drugs, or infections. Foy et al (1961) reported their observations on five patients with kwashiorkor who developed aplasia of the red cells. They believed it was due to riboflavin deficiency.…”

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confidence: 99%

Erythroid Hypoplasia in Kwashiorkor

Walt¹,

Taylor²,

Magill³

et al. 1962

BMJ

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“…Nevertheless, the 51Cr survival rate of the RBC remained unim proved, so that the anemia persisted. In addition to the increase of GR activity, successful treatment with riboflavin in hemolytic or aplastic anemia has been claimed by other authors, who have nevertheless failed to submit details of their experimental or clinical findings [8].…”

Section: Discussionmentioning

confidence: 99%

Hemolytic Anemia and Pancytopenia in Glutathione Reductase Deficiency: Further Experience with Riboflavin

Goebel¹,

Goebel²

1972

Acta Haematol

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Three cases of hemolytic anemia and pancytopenia with glutathione reductase (GR) deficiency are described. Since flavin adenine dinucleotide is the prosthetic group of GR, riboflavin was administered in order to increase the enzyme activity. Despite the return of the GR activity to normal values, the hemolytic anemia and pancytopenia did not improve. It is conceivable that our cases might represent a latent form of leukemia.

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Pure Red-cell Aplasia in Marasmus and Kwashiorkor Treated with Riboflavine

Cited by 49 publications

References 16 publications

The Rapid Induction of Human Riboflavin Deficiency with Galactoflavin *

The Rapid Induction of Human Riboflavin Deficiency with Galactoflavin *

Erythroid Hypoplasia in Kwashiorkor

Hemolytic Anemia and Pancytopenia in Glutathione Reductase Deficiency: Further Experience with Riboflavin

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