Pure Red Cell Aplasia Caused by Azathioprine

Abstract

Pure red cell aplasia (PRCA) is a clinical entity comprising severe normochromic normocytic anemia, reticulocytopenia, erythroblastopenia in the bone marrow, with normal leukocyte and platelets count. PRCA can be classified into congenital and acquired, with the latter characterized as idiopathic or secondary to various infections, hematological malignancies, collagen vascular diseases, thymoma, and exposure to a variety of drugs and other chemical substances. Herein, we present a female patient, who presented with PRCA due to azathioprine treatment. Prompt discontinuation of the drug together with red blood cells transfusions led to complete recovery in this young patient, without any addition of immunosuppressive regimen.

Tissue resident memory T cells in lesional and non‐lesional psoriatic skin on a scar

“…1 In addition, epidermis from never-lesional skin from psoriatic patients skews populations of CD8 + T RM . 4 Given that scar provides the background of K€ obner phenomenon, epidermal T RM should be elevated in scars and reactivated by additional local or systemic factors. In this scenario, it is possible that unknown factors or antigens activate T RM , presumably through T-cell receptors, and the excreted cytokines stimulate keratinocytes to initiate the amplification loop.…”

Anemia in a psoriatic patient treated with ixekizumab

“…Multiple drugs have been associated with PRCA. 4 Recovering from anemia after drug discontinuation varies depending on the pharmacokinetics of the drug, metabolism, duration of treatment and mechanisms by which erythropoiesis is suppressed.…”