Pure red cell aplasia as possible early manifestation of chronic myeloid leukemia

Abstract

Cytogenetic studies as well as erythroid and myeloid progenitor cell assays were performed in a 29-yr-old epileptic man with pure red cell aplasia (PRCA) who had been treated with primidone for several years. Despite clinical evidence of preleukemia, our studies indicated an underlying atypical Philadelphia chromosome-positive myeloproliferative disorder. These laboratory findings were confirmed by the subsequent development of chronic myeloid leukemia (CML) which terminated in a CALLA-positive lymphoblastic crisis 32 months later. The rare concurrent occurrence of PRCA and CML and the possible inducing role of the preceding antiepileptic treatment are discussed.

TKI-induced pure red cell aplasia: first case report of pure red cell aplasia with both imatinib and nilotinib

“… 7 However, the association with CML is very rare with only three reported cases so far. 8–10 Although TKIs are associated with various haematological toxicities, PRCA is not one of them. In fact, there are only two case reports published until now of PRCA induced by any TKI, both with imatinib.…”

Pure red cell aplasia in a patient with chronic granulocytic leukaemia treated with interferon-α

“…1981 ). In one case it was reported as a possible early manifestation of CGL ( Haas, Hinterberger & Morz 1988) or chronic myelomonocytic leukaemia (CMML) ( Bolton‐Maggs, Galloway & Rhodes 1989). It may precede, coincide or follow the development of CGL.…”