Pure primary osteosarcoma of the ovary presenting as an extensively calcified adnexal mass: A case report and review of the literature

Hines, Jeffrey F.; Compton, David M.; Stacy, Carl C.; Potter, M.

doi:10.1016/0090-8258(90)90248-j

Cited by 20 publications

(10 citation statements)

References 15 publications

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“…In this case, however, no discrete ovarian tumor was recognized throughout the course of the illness, and most of the uterine corpus had been replaced by the tumor when the initial symptoms developed. Furthermore, primary ovarian osteosarcoma has been reported as a solid and cystic mass largely confined to the ovary, leaving the uterus intact 24,25 . In contrast, ovarian involvement of uterine osteosarcomas has been documented 15,18 …”

Section: Discussionmentioning

confidence: 99%

Primary osteosarcoma of the uterine corpus: Case report and review of the literature

Tokairin

Nishikawa

et al. 2002

Pathology International

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A rare case of rapidly growing osteosarcoma that developed in the uterine corpus of a 62-year-old woman is presented. The tumor occupied almost the entire pelvic cavity and extended into the abdominal cavity, with marked involvement of the intestines. Histopathologically, the tumor was composed of an osteoblastic component, accompanied by conspicuous bone formation, and a fibroblastic component. The tumor cells were positive for vimentin and osteocalcin, as well as desmin, alpha-smooth muscle actin and muscle-specific actin, but negative for h-caldesmon. The results indicated myofibroblastic differentiation in a part of the tumor. A review of 14 reported cases and our case of uterine osteosarcoma revealed that this tumor has a biologically aggressive nature, although its histopathological and immunohistochemical features are similar to those of osteosarcomas in soft tissue and bone. As the prognosis of patients with this tumor is poor, it is of importance to differentiate this tumor from other types of tumors arising from the uterine corpus.

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Section: Discussionmentioning

confidence: 99%

Primary osteosarcoma of the uterine corpus: Case report and review of the literature

Tokairin

Nishikawa

et al. 2002

Pathology International

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“…Five (83%) of 6 Group A patients and 2 (40%) of 5 Group B patients died of their disease an average of 4.8 and 3.5 months after initial evaluations respectively. However, 2 of the 3 patients who presented with stage 1 disease have shown no evidence of tumor recurrence at an average of 26 months_ follow-up (6,11). Follow-up information was not stated in the third patient with stage 1 disease (5).…”

Section: Discussionmentioning

confidence: 87%

“…The similarity in the clinicopathological profiles of the Group A and Group B cases supports this possibility. However, the case of a stage 1 osteosarcoma reported by Himes et al (11), in which the tumor was completely confined to the ovary and which was unassociated with a teratoma, suggests that osteosarcomas may arise as pure lesions.…”

Section: Discussionmentioning

confidence: 93%

Primary Osteosarcoma of the Ovary

Fadare

Bossuyt

Martel

et al. 2007

International Journal of Gynecological Pathology

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Pure osteosarcomas, in which this tumor is not the mesenchymal component of a biphasic tumor, are only rarely encountered in the ovary. Herein, we report a case of a pure ovarian osteoarcoma and review all previously reported cases of ovarian involvement by osteosarcoma in the English literature. The latter includes (with the present case) 6 cases of pure osteosarcoma (Group A), 5 cases of osteosarcoma arising from a teratoma (Group B), and 2 cases of osteosarcomas of osseous origin (humerus and maxilla) metastatic to the ovary (Group C). The average ages of the Groups A, B, and C patients were 52.6, 52, and 37.5 years, respectively. The average tumor sizes in these groups were 13.46, 13.82, and 16 cm, respectively. There was no statististically significant difference between the Group A and B patients with respect to tumor size (P = 0.94) or age (P = 0.96) (t test). Eight of the 11 patients in groups A and B were FIGO stage 3 or 4 at presentation. Five (83%) of the 6 group A patients and 2 (40%) of the 5 group B patients died of their disease an average of 4.8 and 3.5 months after initial evaluations respectively. However, the 2 patients who presented with stage 1 disease (and with follow-up information) have shown no evidence of tumor recurrence at an average of 26 months' follow-up. It is concluded that ovarian osteosarcomas are rare malignancies that are frequently associated with teratomas but may be seen in pure form. Unlike osseous osteosarcoma whose peak age of incidence is in the second decade, ovarian osteosarcomas occur at an older age group. Most patients have advanced stage disease at presentation. Ovarian osteosarcomas have a high (>60%) case fatality rate; analysis of the reported cases suggests that the latter is attributable to the advanced stage at which most patients present, as there are no reported cases of patients with stage 1 disease whose diseases have recurred after surgical resection or who have died of their disease.

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“…When feasible, surgery is the same as for epithelial ovarian carcinoma with the aim of optimal cytoreductive surgery which means with no residual disease including hysterectomy with bilateral salpingo-oophorectomy, omentectomy, pelvic and para-aortic lymphadenectomy but, because this tumor is rapidly progressing with diagnosis at FIGO stages III or IV, the most frequent scheme is biopsy, neoadjuvant chemotherapy, surgical resection and adjuvant therapy. Therapeutic approaches differ in the literature [5][6][7][8][9][10][11][12][13][14][15]. Six patients had surgery (radical in only 2 cases) and then received adjuvant chemotherapy in various ways.…”

Section: Discussionmentioning

confidence: 99%