Primary osteosarcoma of the uterine corpus: Case report and review of the literature

Abstract

A rare case of rapidly growing osteosarcoma that developed in the uterine corpus of a 62-year-old woman is presented. The tumor occupied almost the entire pelvic cavity and extended into the abdominal cavity, with marked involvement of the intestines. Histopathologically, the tumor was composed of an osteoblastic component, accompanied by conspicuous bone formation, and a fibroblastic component. The tumor cells were positive for vimentin and osteocalcin, as well as desmin, alpha-smooth muscle actin and muscle-specific actin, but negative for h-caldesmon. The results indicated myofibroblastic differentiation in a part of the tumor. A review of 14 reported cases and our case of uterine osteosarcoma revealed that this tumor has a biologically aggressive nature, although its histopathological and immunohistochemical features are similar to those of osteosarcomas in soft tissue and bone. As the prognosis of patients with this tumor is poor, it is of importance to differentiate this tumor from other types of tumors arising from the uterine corpus.

Primary osteosarcoma of the uterus with cardiac and pulmonary metastases

“…Five patients had pulmonary metastasis. Table 1 summarizes the findings associated with those previously reported patients with pulmonary metastasis and the findings associated with our case ( Stier and Lyman, 1936 , Carleton and Williamson, 1961 , Jotkowitz and Valentine, 1985 , Emoto et al, 1994 , Piscioli et al, 1985 , Su et al, 2002 ). None of the patients initially presented with pulmonary metastases at the time of diagnosis.…”

“…This was ruled out based on negative keratin staining. Moreover, the tumor in our case was not described as polypoid and projecting into the uterine cavity as is the description associated with MMMT ( Su et al, 2002 ).…”

A Functional Genomic Study to Identify Differential Gene Expression in the Preterm and Term Human Myometrium1

“…Some of the proliferation-associated genes that were downregulated in our experiments had already been reported to be related to uterine cell tumor development. This is true for the high-mobility group protein HMGIC, which is involved in the development of uterine leiomyomas [34], and osteocalcin, which has been found in osteosarcomas developed in the uterine corpus [35]. The list of down-regulated genes also includes the LIFR (leukemia inhibitory factor receptor) and gp130, a component of the LIF receptor (also known as interleukin-6 signal transducer, IL6ST).…”

Primary osteosarcoma of the uterine cervix: A case report

“…Primary uterine osteosarcoma is an extremely rare gynecological malignancy. Nineteen cases of osteosarcoma with uterine corpus origin have been reported; however, we found only one case of primary uterine cervical osteosarcoma in the English literature . Herein, we report the clinicopathological characteristics of a second case of primary uterine cervical osteosarcoma.…”