Primary osteosarcoma of the uterus with cardiac and pulmonary metastases

Abraham, Cynthia; O’Cearbhaill, Roisin E.; Soslow, Robert A.

doi:10.1016/j.gore.2014.07.002

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…Herein, we describe a case of an extremely rare pure primary osteosarcoma arising from the uterus. To our knowledge, only 15 cases of this type of cancer have been reported to date (Table ) …”

Section: Discussionmentioning

confidence: 99%

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Primary osteosarcoma of the uterine corpus: A case report

Tsukasaki

Mori

Yasukawa

et al. 2016

J of Obstet and Gynaecol

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Pure osteosarcoma arising from the uterus is extremely rare. Only 15 cases of this type of cancer have been reported to date. Most patients showed local or lung metastasis early after surgery and died within a year of treatment initiation, regardless of multimodality therapy, indicating that this tumor is aggressive with a poor prognosis. Herein, we report the first clinical experience treated with a combination of docetaxel and gemcitabine for local and lung metastasis from primary osteosarcoma of the uterus. Although the disease was considered stable after three cycles of treatment, new metastatic lesions appeared in the lungs after six cycles. The patient was asymptomatic for 13 months; however, she died two months after symptom recurrence. Our case demonstrates that a combined regimen of docetaxel and gemcitabine may be a sound therapeutic option to control primary osteosarcoma of the uterus.

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Section: Discussionmentioning

confidence: 99%

“…Osteosarcoma arising from the uterus is an extremely aggressive tumor with a poor prognosis (mean survival 8.1 months; range 20 days–37 months) . Hysterectomy and bilateral salpingo‐oophorectomy were performed in all 15 cases, shown in Table .…”

Section: Discussionmentioning

confidence: 99%

Primary osteosarcoma of the uterine corpus: A case report

Tsukasaki

Mori

Yasukawa

et al. 2016

J of Obstet and Gynaecol

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“…Primary uterine osteosarcoma is an extremely rare gynecological malignancy. Nineteen cases of osteosarcoma with uterine corpus origin have been reported; however, we found only one case of primary uterine cervical osteosarcoma in the English literature . Herein, we report the clinicopathological characteristics of a second case of primary uterine cervical osteosarcoma.…”

Section: Introductionmentioning

confidence: 86%

Primary osteosarcoma of the uterine cervix: A case report

Tsuji

Watanabe

Tokunaga

et al. 2017

J of Obstet and Gynaecol

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Primary osteosarcoma of the uterine cervix is extremely rare. Only 20 cases have been reported, 19 of which originated in the uterine corpus. We report a case of primary uterine cervical osteosarcoma with pulmonary metastasis in a 30-year-old nulligravida woman. The initial diagnosis was carcinosarcoma of the uterine cervix, as detected by cervical cytology and biopsy analysis. We performed a total hysterectomy, bilateral salpingo-oophorectomy and colostomy without macroscopic residual tumors in the abdominal cavity, but pelvic recurrent tumors appeared 14 days postoperatively. Both recurrent and metastatic tumors were effectively reduced by combination therapy of adriamycin with ifosfamide; however, the patient died as a result of of disease progression nine months after her first visit to our department.

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“…Uterine sarcomas can be classified as homologous (composed of intrinsic uterine components) or heterologous (composed of foreign components such as cartilage and bone). Most uterine sarcomas are homologous, and heterologous uterine osteosarcomas are extremely rare ( 1 ). The majority of heterologous uterine tumors are classified as malignant mixed mullerian tumors (MMMTs).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Clinical application of immunotherapy-based combination regimen in primary osteosarcoma of the uterus

Yang

Chen

et al. 2023

Front. Oncol.

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Primary osteosarcoma of the uterus is an extremely rare pure heterologous sarcoma of the uterus. The relevant available information is limited to case reports. To date, only 31 cases of this type of cancer have been reported. Here, we report the first clinical experience with the administration of an immunotherapy-based combination regimen for multiple metastatic primary osteosarcomas of the uterus. The patient had undergone multiple treatments prior to this regimen, but her condition continued to progress. However, after 3 cycles of immunotherapy combined with targeted therapy and chemotherapy, a review showed that the disease was stable and even in partial remission. The patient has a good quality of life, and long-term survival is expected.

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Primary osteosarcoma of the uterus with cardiac and pulmonary metastases

Cited by 10 publications

References 8 publications

Primary osteosarcoma of the uterine corpus: A case report

Primary osteosarcoma of the uterine corpus: A case report

Primary osteosarcoma of the uterine cervix: A case report

Case Report: Clinical application of immunotherapy-based combination regimen in primary osteosarcoma of the uterus

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