Pure primary choriocarcinoma of the urinary bladder with long-term survival

Mixed micropapillary and trophoblastic carcinoma of bladder: report of a first case with new immunohistochemical evidence of urothelial origin

“…3,7,8 Expression of hCG has been associated with radioresistance, even in TCC without trophoblastic cells, 13 and TBC response to chemotherapy has been disappointing, with few reports of improved outcome. 5,6 The current case, to my knowledge, is the first reported instance of mixed MPC and TBC. The case is interesting in various respects.…”

“…[3][4][5][6][7][8] According to the literature, the mean age is 64 years, and the male-to-female ratio is 3:1. These tumors contain syncytial and mononuclear trophoblastic cells; all cases stained for hCG have been positive, and virtually all patients tested have shown elevated serum and urine hCG levels.…”

Rectal adenocarcinoma with choriocarcinomatous differentiation: Clinical and genetic aspects

“…They occur in the gastrointestinal tract, with tumors described in the esophagus, stomach, small intestine, colon, rectum, and the gall bladder, as well as in the urinary tract and the lung. [1][2][3][4][5][6][7][8] Histologically a biphasic tumor growth with adenocarcinomatous or transitional cell carcinomatous parts, depending on the originating site, and choriocarcinomatous parts is a recurrent finding. 5 Clinically, these tumors show an aggressive behavior.…”

“…1 One study using fluorescence in situ hybridization (FISH) reported the presence of an isochromosome 12p in a pure choriocarcinoma of the bladder. 7 Gain of genetic material derived from the short arm of chromosome 12, as seen in germ cell cancer, is unusual for these cancer sites and was suggested to be associated with choriocarcinomatous differentiation.…”

Trophoblastic Diseases

“…They are defined as gestational choriocarcinoma or trophoblastic disease (GTD 16 Uterine cervical choriocarcinoma was also experienced. 17 Choriocarcinoma is constructed of syncytia and cytotrophoblasts and shows no villus pattern at all (Figs 4A to D).…”