Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFα, IL-1β, NO and MAP kinases

Olibanum Extract Inhibits Vascular Smooth Muscle Cell Migration and Proliferation in Response to Platelet-Derived Growth Factor

“…In the present study, PDGF increased the phosphorylation of ERK1/2 in the RASMCs, and this response was not inhibited by treatment with olibanum extract. Similarly, a previous report demonstrated that olibanum extract did not induce ERK1/2 phosphorylation in response to LPS, in different cells than the type used in this study (Gayathri et al, 2007), Therefore, it is possible that olibanum extract does not affect the ERK1/2 activity in RASMCs, and this kinase pathway might not be involved in the olibanum extract inhibition of PDGF-induced migration and proliferation of the RASMCs. These results suggest that MAPK isoforms may be regulated differently by olibanum extract.…”

“…Based on the positive results in animal studies and clinical trials of the European Medicine Agency in 2002, olibanum extract was designated orphan drug status for the treatment of the peritumor edema associated with brain tumors (Winking et al, 2000). It has been reported that olibanum extract affects the migration and proliferation of cells including cancer cells and lymphocytes (Sharma et al, 1988;Gayathri et al, 2007). These findings have suggested that olibanum extract exerts an inhibitory effect on vascular smooth muscle cell behavior.…”

“…PDGF enhances the phosphorylation of p38 MAPK and ERK1/2, and increases the migration and proliferation of RASMCs . Moreover, it has recently been reported that the olibanum extract from Boswellia serrata inhibits the LPS-induced phosphorylation of MAPKs, JNK and p38 MAPK, in blood mononuclear cells (Gayathri et al, 2007); these findings imply that olibanum can exert an inhibitory effect on the MAPK signaling pathway. In this study, we explored the possible role of p38 MAPK and ERK 1/2, and the effects of olibanum on PDGF-induced RASMC migration and proliferation; JNK, an important isoenzyme of MAPK was not included because these two PDGF-induced RASMC responses (proliferation and migration) were not significantly suppressed by JNK inhibition in previous studies .…”

“…The resin extracts have been shown to have anti-cancer effects in leukemia and brain tumors (Winking et al, 2000). The extracts are also known to influence cellular responses such as the proliferation of liver cancer cells and lymphocytes (Gayathri et al, 2007), and the migration of leukocytes (Sharma et al, 1988). However, it is not been known whether olibanum extracts affect vascular smooth muscle cell behavior, such as migration and proliferation.…”

Enhanced Bioavailability of Glimepiride in the Presence of Boswellic Acids in Streptozotocin-Induced Diabetic Rat Model

“…The 6 major active components in B. serrata are α-Boswellic acid, β-Boswellic acid, 3-Acetyl-α-Boswellic acid, 3-Acetyl-β-Boswellic acid, 11-keto-β-Boswellic acid and 3-Acetyl-11-keto-β-Boswellic acid. Many studies have shown that B. serrata and its major component, BA have various pharmacological activities, such as anti-inflammatory [6], anticancer [7], anti-arthritic [8], immunomodulatory [9], antidiabetic [10] and analgesic [11].…”