Eur J Chem volume 10, issue 4, P350-357 2019 DOI: 10.5155/eurjchem.10.4.350-357.1899
Maha Mahmoud Abou El-Alamin, Maha Abd Elrahman Sultan, Maha Hegazy, Alastair William Wark, Marwa Mohamed Azab

Daclatasvir (DAC), sofosbuvir (SOF) and ribavirin (RIB) have been recently co-formulated in tablet dosage form for the treatment of Hepatitis C virus infections. In this work, the resolution and quantitation of overlapped spectral signals was achieved by both univariate and multivariate algorithms. Pure component contribution algorithm (PCCA) as a novel approach was applied along with factor based partial least squares (PLS) algorithms using both full range and synergistic intervals (siPLS). Each drug coul…


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