Pure Component Contribution (PCCA) and Synergy Interval Partial Least Squares (siPLS) Algorithms for Efficient Resolution and Quantification of Overlapped Signals; An Application to Novel Antiviral Tablets of Daclatasvir, Sofosbuvir and Ribavirin

Abstract

Daclatasvir (DAC), sofosbuvir (SOF) and ribavirin (RIB) have been recently co-formulated in tablet dosage form for the treatment of Hepatitis C virus infections. In this work, the resolution and quantitation of overlapped spectral signals was achieved by both univariate and multivariate algorithms. Pure component contribution algorithm (PCCA) as a novel approach was applied along with factor based partial least squares (PLS) algorithms using both full range and synergistic intervals (siPLS). Each drug could be…