Pure chitosan microfibres for biomedical applications

Toskas, Georgios; Brünler, Ronny; Hund, Heike; Hund, Rolf-Dieter; Hild, Martin; Aibibu, Dilibaier; Cherif, Chokri

doi:10.2478/v10304-012-0041-5.

Cited by 5 publications

(9 citation statements)

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“… Besides the well-established synthetic polymers (e.g. PLA, PGA, PLGA, PBT), recent developments in biomaterial fiber engineering enable the exploitation of the favorable material properties from materials such as collagen, chitosan, regenerated silk or recombinant proteins in fibers suitable for their processing into stable spatial scaffolds [ 51 , 80 , 116 , 117 ]. However, intensified studies concerning fiber properties and the in vitro and in vivo behavior of those newly developed fibers have to be conducted in order to use them for regenerative medicine.…”

Section: Discussionmentioning

confidence: 99%

“…2 Engineering process of fibrous architectures as templates for TE/in situ TE applications. Image source: a [ 46 ], b [ 47 ], c [ 48 ], d [ 49 ], e [ 50 ], f [ 51 ], g courtesy of TU Dresden …”

Section: Benefits Of Engineered Fibrous Scaffold Architecturesmentioning

confidence: 99%

“…abundant availability, osteoactivity, promotes wound healing, anti-bacterial effects) Chitosan (CS), a partially deacetylated derivative of Chitin, has been widely used in applications for regenerative medicine [ 102 , 103 ]. Chitosan fibers may be produced by electrospinning [ 104 ], microfluidic spinning [ 105 ] or wet spinning techniques [ 51 , 106 – 108 ].…”

Section: Benefits Of Engineered Fibrous Scaffold Architecturesmentioning

confidence: 99%

“…Toskas and colleagues successfully developed an industrial-scale process to generate pure chitosan multifibers (Fig. 3 f–i) [ 51 ]. They dissolved up to 8.5 wt%.…”

Section: Benefits Of Engineered Fibrous Scaffold Architecturesmentioning

confidence: 99%

“…Tensile strength of 15.9 cN/tex was achieved. Woven and knitted fabrics with adequate mechanical properties could be manufactured [ 51 ]. Textile scaffolds made of these CS fibers were tested in vitro, yielding promising results for further use in TE applications [ 47 , 112 ].…”

Section: Benefits Of Engineered Fibrous Scaffold Architecturesmentioning

confidence: 99%

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Textile cell-free scaffolds for in situ tissue engineering applications

Aibibu

Hild

Wöltje

et al. 2016

J Mater Sci: Mater Med

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In this article, the benefits offered by micro-fibrous scaffold architectures fabricated by textile manufacturing techniques are discussed: How can established and novel fiber-processing techniques be exploited in order to generate templates matching the demands of the target cell niche? The problems related to the development of biomaterial fibers (especially from nature-derived materials) ready for textile manufacturing are addressed. Attention is also paid on how biological cues may be incorporated into micro-fibrous scaffold architectures by hybrid manufacturing approaches (e.g. nanofiber or hydrogel functionalization). After a critical review of exemplary recent research works on cell-free fiber based scaffolds for in situ TE, including clinical studies, we conclude that in order to make use of the whole range of favors which may be provided by engineered fibrous scaffold systems, there are four main issues which need to be addressed: (1) Logical combination of manufacturing techniques and materials. (2) Biomaterial fiber development. (3) Adaption of textile manufacturing techniques to the demands of scaffolds for regenerative medicine. (4) Incorporation of biological cues (e.g. stem cell homing factors).

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Section: Discussionmentioning

confidence: 99%

Section: Benefits Of Engineered Fibrous Scaffold Architecturesmentioning

confidence: 99%

Section: Benefits Of Engineered Fibrous Scaffold Architecturesmentioning

confidence: 99%

“…Toskas and colleagues successfully developed an industrial-scale process to generate pure chitosan multifibers (Fig. 3 f–i) [ 51 ]. They dissolved up to 8.5 wt%.…”

Section: Benefits Of Engineered Fibrous Scaffold Architecturesmentioning

confidence: 99%

Section: Benefits Of Engineered Fibrous Scaffold Architecturesmentioning

confidence: 99%

See 3 more Smart Citations

Textile cell-free scaffolds for in situ tissue engineering applications

Aibibu

Hild

Wöltje

et al. 2016

J Mater Sci: Mater Med

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Factors affecting the mechanical and geometrical properties of electrostatically flocked pure chitosan fiber scaffolds

Tonndorf

Gossla

Kocaman

et al. 2017

Textile Research Journal

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The field of articular cartilage tissue engineering has developed rapidly, and chitosan has become a promising material for scaffold fabrication. For this paper, wet-spun biocompatible chitosan filament yarns were converted into short flock fibers and subsequently electrostatically flocked onto a chitosan substrate, resulting in a pure, highly open, porous, and biodegradable chitosan scaffold. Analyzing the wet-spinning of chitosan revealed its advantages and disadvantages with respect to the fabrication of the fiber-based chitosan scaffolds. The scaffolds were prepared using varying processing parameters and were analyzed in regards to their geometrical and mechanical properties. It was found that the pore sizes were adjustable between 65 and 310 µm, and the compressive strength was in the range 13–57 kPa.

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Electroactive composites based on chitosan fibers coated with polypyrrole

Dresvyanina

Rosova

Смирнова

et al. 2021

Textile Research Journal

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Chitosan fibers were prepared by coagulation from 4% chitosan solutions in 2% acetic acid solution. The synthesis method for polypyrrole (PPy) involving in situ oxidative polymerization of gaseous pyrrole on the surface of chitosan fibers was developed. Structure of the composites was studied by scanning electron microscopy. Electrical conductivity and mechanical characteristics of the obtained composite systems were determined. It was shown that formation of PPy layers on chitosan fibers leads to appearance of electrical conductivity. Conductivity of these layers, as well as their mechanical characteristics, depends on polymerization conditions. The MTT test (a colorimetric assay for assessing cell metabolic activity) showed good biocompatibility of chitosan–PPy composite films; these films contain higher amounts of viable cells than the films cast from solutions of pure chitosan.

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Pure chitosan microfibres for biomedical applications

Cited by 5 publications

References 0 publications

Textile cell-free scaffolds for in situ tissue engineering applications

Textile cell-free scaffolds for in situ tissue engineering applications

Factors affecting the mechanical and geometrical properties of electrostatically flocked pure chitosan fiber scaffolds

Electroactive composites based on chitosan fibers coated with polypyrrole

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