Textile cell-free scaffolds for in situ tissue engineering applications

Aibibu, Dilbar; Hild, Martin; Wöltje, Michael; Cherif, Chokri

doi:10.1007/s10856-015-5656-3

Cited by 34 publications

(32 citation statements)

References 214 publications

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“…The application of textiles techniques has been widely-used for tissue engineering as it offers the possibility of creating complex hierarchical 3D structures with tailored mechanical properties similar to native tissues [ 144 ]. Knitting offers the possibility of creating 3D structures made of interconnected loops of yarns or threads [ 109 ] that determine both their mechanical properties and their porosity [ 37 ].…”

Section: Tendonmentioning

confidence: 99%

Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

et al. 2018

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Tissue engineering is a promising approach to repair tendon and muscle when natural healing fails. Biohybrid constructs obtained after cells’ seeding and culture in dedicated scaffolds have indeed been considered as relevant tools for mimicking native tissue, leading to a better integration in vivo. They can also be employed to perform advanced in vitro studies to model the cell differentiation or regeneration processes. In this review, we report and analyze the different solutions proposed in literature, for the reconstruction of tendon, muscle, and the myotendinous junction. They classically rely on the three pillars of tissue engineering, i.e., cells, biomaterials and environment (both chemical and physical stimuli). We have chosen to present biomimetic or bioinspired strategies based on understanding of the native tissue structure/functions/properties of the tissue of interest. For each tissue, we sorted the relevant publications according to an increasing degree of complexity in the materials’ shape or manufacture. We present their biological and mechanical performances, observed in vitro and in vivo when available. Although there is no consensus for a gold standard technique to reconstruct these musculo-skeletal tissues, the reader can find different ways to progress in the field and to understand the recent history in the choice of materials, from collagen to polymer-based matrices.

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Section: Tendonmentioning

confidence: 99%

Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

et al. 2018

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“…When the ECM is healthy, it can properly exert all of its functions on cells embedded within its complex and information‐rich microenvironment; the structural integrity of the ECM is able to promote cellular adhesion, maintain extracellular homeostasis and support signal transduction. To use the whole range of functions, an artificial cell home engineered with tailorable biomechanical characteristics that allow adhesion and the creation of contractility in the cell cytoskeleton, accompanied by controlled ligand and signal presentation for directed intracellular signaling and gene expression, is indispensable . Because all these critical functions are mediated by multiple ECM components, a medley of cell‐secreted factors and mixed cell populations that interact heterotypically, scientists have applied biomimicry to replicate ECM proteins in terms of their form and function …”

Section: Recreating Cell–ecm Interactions In a Cell Homementioning

confidence: 99%

Engineering a Cell Home for Stem Cell Homing and Accommodation

Yin

et al. 2017

Adv. Biosys.

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Distilling complexity to advance regenerative medicine from laboratory animals to humans, in situ regeneration will continue to evolve using biomaterial strategies to drive endogenous cells within the human body for therapeutic purposes; this approach avoids the need for delivering ex vivo‐expanded cellular materials. Ensuring the recruitment of a significant number of reparative cells from an endogenous source to the site of interest is the first step toward achieving success. Subsequently, making the “cell home” cell‐friendly by recapitulating the natural extracellular matrix (ECM) in terms of its chemistry, structure, dynamics, and function, and targeting specific aspects of the native stem cell niche (e.g., cell–ECM and cell–cell interactions) to program and steer the fates of those recruited stem cells play equally crucial roles in yielding a therapeutically regenerative solution. This review addresses the key aspects of material‐guided cell homing and the engineering of novel biomaterials with desirable ECM composition, surface topography, biochemistry, and mechanical properties that can present both biochemical and physical cues required for in situ tissue regeneration. This growing body of knowledge will likely become a design basis for the development of regenerative biomaterials for, but not limited to, future in situ tissue engineering and regeneration.

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“…The so called electrochemical alignment technique is an interesting strategy that allows producing anisotropically aligned collagen bundles through a process based on the pH gradient created between two parallel electrodes [46,67,85]. This strategy was firstly proposed for TE of connective tissues by Akkus group [86], that have been developing this technique, culminating in a recent proposed system for Fig.…”

Section: Electrochemical Alignment Techniquementioning

confidence: 99%

Biomaterials as Tendon and Ligament Substitutes: Current Developments

Santos¹,

Rodrigues²,

Domingues³

et al. 2016

Regenerative Strategies for the Treatment of Knee Joint Disabilities

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Tendon and ligament have specialized dynamic microenvironment characterized by a complex hierarchical extracellular matrix essential for tissue functionality, and responsible to be an instructive niche for resident cells. Among musculoskeletal diseases, tendon/ligament injuries often result in pain, substantial tissue morbidity, and disability, affecting athletes, active working people and elder population. This represents not only a major healthcare problem but it implies considerable social and economic hurdles. Current treatments are based on the replacement and/or augmentation of the damaged tissue with severe associated limitations. Thus, it is evident the clinical challenge and emergent need to recreate native tissue features and regenerate damaged tissues. In this context, the design and development of anisotropic bioengineered systems with potential to recapitulate the hierarchical architecture and organization of tendons and ligaments from nano to macro scale will be discussed in this chapter. Special attention will be given to the state-of-the-art fabrication techniques, namely spinning and electrochemical alignment techniques to address the demanding requirements for tendon substitutes, particularly concerning the importance of biomechanical and structural cues of these tissues. Moreover, the poor innate regeneration ability related to the low cellularity and vascularization of tendons and ligaments also anticipates the importance of cell based strategies, particularly on the stem cells role for the success of tissue engineered therapies. In summary, this chapter provides a general overview on tendon and ligaments physiology and current conventional treatments for injuries caused by trauma and/or disease. Moreover, this chapter presents tissue engineering approaches as an alternative to overcome the limitations of current therapies, focusing on the discussion about scaffolds design for tissue substitutes to meet the regenerative medicine challenges towards the functional restoration of damaged or degenerated tendon and ligament tissues.

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Textile cell-free scaffolds for in situ tissue engineering applications

Cited by 34 publications

References 214 publications

Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

Engineering a Cell Home for Stem Cell Homing and Accommodation

Biomaterials as Tendon and Ligament Substitutes: Current Developments

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