Pure Atmospheric Pressure Promotes an Expression of Osteopontin in Human Aortic Smooth Muscle Cells

Osteopontin Promoter Polymorphism Is Associated With Increased Carotid Intima-Media Thickness

“…8,10,15,16,48,50 Limitations of the study OPN controls intima-media thickness in preclinical models, upregulated in VSMCs by the very glycemic and mechanical stresses that are critical determinants of CIMT in human. 9,29,51 However, the precise levels of carotid VSMC OPN accumulation and MMP activation in the present cohort is unknown. These data would be highly desirable, since our working model postulates that the dysmetabolic state of the metabolic syndrome (MetS) "overrides" the basal, genetically-inherited influence of the OPN T-66G genotype to drive CIMT progression (see Figure 2).…”

Transcription Profiles of Aortic Smooth Muscle Cells from Atherosclerosis-Prone and -Resistant Regions in Young Apolipoprotein E-Deficient Mice before Plaque Development

“…In vitro overexpression of osteopontin promotes vascular SMC proliferation [63], and in vivo overexpression is associated with increased thickening of the media with aging and of the intima after arterial injury [64]. Finally, Iizuka et al [65 ]reported that atmospheric pressure promotes osteopontin expression in human aortic SMCs. The microarray analysis demonstrated increased gene expression of osteopontin at the atherosclerosis-prone location, but both validation assays pointed to a large interindividual variance between mice.…”

Effect of traditional Chinese medicine Qin-Dan-Jiang-Ya-Tang on remodeled vascular phenotype and osteopontin in spontaneous hypertensive rats

“…Vitro studies have shown that OPN is associated with proliferation (Gadeau et al, 1993) and migration (Chaulet et al, 2001) of rat cultured VSMCs. OPN identified as a developmentally regulated novel smooth muscle cell product (Giachelli et al, 1991) has recently emerged as a key factor in vascular remodeling in the development of hypertension (Iizuka et al, 2001;Sun et al, 2004).…”