PuraMatrix Encapsulation of Cancer Cells

Abu-Yousif, Adnan O.; Rizvi, Imran; Evans, Conor L.; Hasan, T.

doi:10.3791/1692-v

Cited by 3 publications

(2 citation statements)

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“…The presence of the ECM in 3D models changes the dynamic of the cell growth and interactions in relation to transport and drug, hormone and growth factor responses (41). The matrices used in 3D models can consist of many substances including reconstituted basement membrane from animals, collagen, fibrin or polyacrylamide gels (43,44). The source of the ECM is very important especially in tumour studies and in studies where tumour and stroma elements are both incorporated, ECM is also produced by some stromal cells (41).…”

Section: Cell Matrixmentioning

confidence: 99%

Lactoferrin and cancer in different cancer models

Jessica¹

2011

Front Biosci

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Lactoferrin (Lf) is a multifunctional protein and an essential element of innate immunity. Cancer is a major killer in today's world accounting for around 13% of all deaths according to the World Health Organisation (W.H.O.). The five most common forms of cancer include lung, colorectal, stomach, liver and breast cancer. Lactoferrin is a natural forming iron-binding glycoprotein with antibacterial, antioxidant and anti-carcinogenic effects. It is produced in exocrine glands and is secreted in many external fluids as a first line of defence. Lactoferrin also has the capacity to induce apoptosis and inhibit proliferation in cancer cells as well as restore white and red blood cell levels after chemotherapy. This review focuses on the therapeutic effect bovine sourced lactoferrin has on various forms of cancer in various models. It also focuses on the benefits of 3D in vitro cell culture. 3D cell culture has vast advantages over 2D models including demonstration of realistic therapeutic results and heightened resistance that 2D models fail to display.

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Section: Cell Matrixmentioning

confidence: 99%

Lactoferrin and cancer in different cancer models

Jessica¹

2011

Front Biosci

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“…Under physiological conditions, the peptides self-assemble into a hydrogel with a nanometer-scale fibrous structure. [23] PM applications not only include in vitro spheroid cultures, [24,25] but also in vivo treatments for hemostasis in cardiovascular, gastrointestinal, and otorhinolaryngological surgical procedures in humans. [26] Interestingly, the FDA approved a 2.5% RADA 16 formulation for clinical use in 2019, [27] positioning PM-based hydrogels as an attractive biomaterial for translational studies.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Endometrial‐Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives

Gómez‐Álvarez,

Bueno‐Fernandez,

Rodríguez‐Eguren

et al. 2023

Adv Healthcare Materials

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The endometrium plays a vital role in fertility, providing a receptive environment for embryo implantation and development. Understanding the endometrial physiology is essential for developing new strategies to improve reproductive healthcare. Human endometrial organoids (hEOs) are emerging as powerful models for translational research and personalized medicine. However, most hEOs are cultured in a 3D microenvironment that significantly differs from the human endometrium, limiting their applicability in bioengineering. This study presents a hybrid endometrial‐derived hydrogel that combines the rigidity of PuraMatrix (PM) with the natural scaffold components and interactions of a porcine decellularized endometrial extracellular matrix (EndoECM) hydrogel. This hydrogel provides outstanding support for hEO culture, enhances hEO differentiation efficiency due to its biochemical similarity with the native tissue, exhibits superior in vivo stability, and demonstrates xenogeneic biocompatibility in mice over a 2‐week period. Taken together, these attributes position this hybrid endometrial‐derived hydrogel as a promising biomaterial for regenerative treatments in reproductive medicine.

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