2018
DOI: 10.1136/bjophthalmol-2018-313267
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Punctal occlusion for dry eye syndrome: summary of a Cochrane systematic review

Abstract: Dry eye disease is a disorder of the tear film associated with ocular signs and symptoms. Punctal occlusion aids the preservation of natural tears. We conducted a Cochrane systematic review to assess the effectiveness of punctal plugs for managing dry eye. Randomised and quasi-randomised trials were included. The primary outcome was symptomatic improvement (SI) at 2–12 months. Nine databases were searched with no date or language restrictions. Two authors assessed trial quality and extracted data. Summary risk… Show more

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Cited by 23 publications
(18 citation statements)
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“…There are proven evidences which showed the efficacy of punctal plug treatment for aqueous deficient type dry eye disease. 73 , 92 , 93 Punctal occlusion improves not only the aqueous components, but the lipid and mucin components as well, because it sustains all the three tear film layer components because of the delayed aqueous tear clearance as stated above. A combination of punctal plug with diquafosol sodium may provide immediate and long-term relief, and is also a viable treatment approach.…”
Section: Tear Film Breakup Patterns and The Classification Of Dry Eyementioning
confidence: 93%
“…There are proven evidences which showed the efficacy of punctal plug treatment for aqueous deficient type dry eye disease. 73 , 92 , 93 Punctal occlusion improves not only the aqueous components, but the lipid and mucin components as well, because it sustains all the three tear film layer components because of the delayed aqueous tear clearance as stated above. A combination of punctal plug with diquafosol sodium may provide immediate and long-term relief, and is also a viable treatment approach.…”
Section: Tear Film Breakup Patterns and The Classification Of Dry Eyementioning
confidence: 93%
“…There were three Cochrane reviews, including 'punctal occlusion for dry eye syndrome' (38,39), 'autologous serum eye drops for dry eye' (40,41) and 'over the counter (otc) artificial tear drops for dry eye syndrome' (42). The first dry eye Cochrane review was Punctal occlusion for dry eye syndrome (39), which was first published in 2010, and had got 19 citations, the second was Punctal occlusion for dry eye syndrome, which was first published in 2013 (41), and had got 12 times. Both the two reviews published their update version in 2017, and these versions were also indexed by Web of Science (38,40).…”
Section: Discussionmentioning
confidence: 99%
“…The first dry eye Cochrane review was Punctal occlusion for dry eye syndrome (39), which was first published in 2010, and had got 19 citations, the second was Punctal occlusion for dry eye syndrome, which was first published in 2013 (41), and had got 12 times. Both the two reviews published their update version in 2017, and these versions were also indexed by Web of Science (38,40). The third was Over the counter (otc) artificial tear drops for dry eye syndrome (42), which was published in 2016, and has been cited by 7 times.…”
Section: Discussionmentioning
confidence: 99%
“…Results show that compared to artificial tears, punctal plug participants have more symptomatic improvement after a period of three months. Besides, punctal plug placement with acrylic, silicone, cyclosporine or pilocarpine, show no statistically significant difference in symptomatic improvement at 2-12 months [154]. Although punctal plugs are believed to be relatively safe, some complications were also found in patients with DED after their use, including extrusion, granulation, pyogenic granuloma, and canaliculitis [155][156][157][158].…”
Section: Punctal Plugmentioning
confidence: 97%