Pulsed laser deposition of strontium-substituted hydroxyapatite coatings

Pereiro, Iago; Rodríguez-Valencia, C.; Serra, C.; Solla, E.L.; Serra, J.; González, P.

doi:10.1016/j.apsusc.2012.04.063

Cited by 68 publications

(37 citation statements)

References 23 publications

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“…Strontium-doped hydroxyapatite (Sr-HAp), with Sr concentration up to 50 mol%, has been synthesized by sol-gel process [64, 92,93], precipitation [49,88,[94][95][96][97], and hydrothermal method [98]. For the production of Sr-HAp coatings, micro-arc treatment [99], pulsed laser deposition [100], laser ablation [101], and biomimetic synthesis [102][103][104] have been employed.…”

Section: Synthesis Of Sr-substituted Hapmentioning

confidence: 99%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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Section: Synthesis Of Sr-substituted Hapmentioning

confidence: 99%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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“…It is used in osteoporosis treatment for many years, and the mineral structure of the bone possesses strontium, particularly at the sections of the elevated metabolic turnover [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of strontium-doped hydroxyapatite for biomedical applications

Özbek

Baştan

Üstel

2016

J Therm Anal Calorim

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The aim of this study was to investigate the effect of strontium (Sr) doping into hydroxyapatite (HA) powders. It is well known that strontium promotes bone formation, reduces bone resorption and it is used to treat osteoporotic diseases as stated previously by researchers. Strontium-doped HA (Sr-HA) was produced by precipitation with increasing amount of ion exchange between calcium (Ca) and Sr. Two different Sr amounts as 2 and 4 mol% were doped into HA by adding Sr(NO 3 ) 2 to the reaction solution. The precipitated HA was separated from supernatant after the vacuum filtration. The filtered wet cake of HA was exposed to spray drying and calcined in an air furnace at 1200°C. The produced-HA powders were analyzed by using SEM, FTIR, XRD and TG-DSC techniques. At the end of the study, the results showed that decomposition of HA to tri-calcium phosphate increases with increasing Sr content. Thermal analyses revealed that Sr-doped HA powders loose more mass than pure HA powders.

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“…The relationship between the Sr content of the targets and the corresponding thin films was found to be roughly proportional, while the value of Sr/(Ca + Sr) of each thin film showed a slight deviation from that of the target. A tendency of Sr defects to exist in PLD-deposited thin films such as these has also been reported in a previous work [16], although the mechanism is not understood. The (Ca + Sr)/P ratios in Figure 1 exhibit some deviation from the stoichiometric value of approximately 1.67, and it can also be observed that the (Ca + Sr)/P ratio of the thin films is not dependent on the Sr content of the target and the thin film.…”

Section: Methodsmentioning

confidence: 81%

“…In this study, we have made progress toward eliminating the possibility that the systematic variation of the lattice constants was caused by a variation of the P content, unlike the previous paper [16]. We have three plans to improve these results in subsequent studies.…”

Section: Resultsmentioning

confidence: 99%

“…These functions of Sr likely derive from its excellent ability to activate osteoblasts and deactivate osteoclasts. On the basis of this knowledge regarding the function of Sr on bone repair, the preparation of Sr-HA has been studied extensively [8] [13] [14] [15] [16]. In these studies, it has been found that Sr can be substituted into Ca 10−x Sr x (PO 4 ) 6 (OH) 2 by up to x = 10 [8] [13] [14] [15], and that the a-and c-axis lengths increase linearly with x [8] [13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Relationship between Sr Content and the Lattice Constants in Sr Substituted Hydroxyapatite Thin Films

Nishikawa¹,

Saito²,

Miyake³

et al. 2017

JCPT

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To increase the biocompatibility of hydroxyapatite (HA), Ca 10 (PO 4 ) 6 (OH) 2 , the Sr substitution of Ca into the HA structure was effected to yield Ca 10−x Sr x (PO 4 ) 6 (OH) 2 (Sr-HA). For medical and dental applications, it is important that Sr-HA is prepared as a thin film so that the Sr fully substitutes the Ca sites in the HA structure and does not form segregated impurities consisting of Sr compounds. If the segregated Sr forms different amounts of different impurities, the dissolution of the Sr into the living body will not be reproducible across different samples. To confirm the Sr substitution into the Ca site in the HA structure, the systematic variation in the lattice constants of the Sr-HA with Sr content was evaluated as the first step. The a-and c-axis lengths were found to exhibit a linear relationship with the Sr content for six samples with different Sr contents, indicating that the prepared Sr-HA thin films likely possessed partial Sr substitution into the Ca sites of the HA structure. This result is an important first step in the accurate evaluation of the biological effects of Sr-HA thin films.

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Pulsed laser deposition of strontium-substituted hydroxyapatite coatings

Cited by 68 publications

References 23 publications

Cationic and Anionic Substitutions in Hydroxyapatite

Cationic and Anionic Substitutions in Hydroxyapatite

Synthesis and characterization of strontium-doped hydroxyapatite for biomedical applications

Systematic Relationship between Sr Content and the Lattice Constants in Sr Substituted Hydroxyapatite Thin Films

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