Synthesis and characterization of strontium-doped hydroxyapatite for biomedical applications

Özbek, Yıldız Yarali; Baştan, Fatih Erdem; Üstel, Fatih

doi:10.1007/s10973-016-5607-3

Cited by 35 publications

(22 citation statements)

References 41 publications

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“…The mass loss up to 200 o C may be due to the evaporation of physically adsorbed water on the surface of particles of HAPs in good agreement with thermal analysis of related compounds [2,3,31,32]. The second mass loss from 200 to 800 o C may correspond to desorption of chemically bounded water to the HAPs lattice, which needs more energy to release that water from HAPs structure, as supported by DSC data (figs.…”

Section: Table 2 the Size Of Crystallites And Crystallinity Degree Fosupporting

confidence: 78%

“…Certainly, water in pores requires more heating to be released due to the capillary effect. Thermal analysis at high temperature might be associated with the gradual loss of lattice water [2,3,21,[31][32][33][34]. Above 800 °C up to 1000 o C, the weight loss is insignificant and cannot be attributed to structural decomposition of HAPs biomaterials.…”

Section: Table 2 the Size Of Crystallites And Crystallinity Degree Fomentioning

confidence: 99%

“…It is recognized that biomaterials based on hydroxyapatite [HAP, Ca 10 (PO 4 ) 6 (OH) 2 ] possess high biocompatibility and good bioactivity, and can stimulate osteoconduction, being slowly replaced by the host bone after implantation [1][2][3]. They are potential alternatives as bone grafts for medical applications and as coatings for metallic implants [1].…”

mentioning

confidence: 99%

“…Doped hydroxyapatites [[HAPs] with Sr [2][3][4][5][6], Mg [2,7,8], Si [9][10][11] and Zn [2,11,12] have the advantage that they inherit the HAP structure and some biological properties of doping elements, that intervene in bone development and metabolism.…”

mentioning

confidence: 99%

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Behavior of Doped Hydroxyapatites During the Heat Treatment

Goga¹,

Forizs²,

Borodi³

et al. 2018

Rev. Chim.

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The goal of this investigation is related to the development of nanostructured biomaterials based on hydroxyapatite (HAP) and multi-doped hydroxyapatites (HAPs), with essential physiological elements, like Mg, Zn, Sr, and Si, for bone repair and regeneration. Nano hydroxyapatites pastes and powders were obtained by wet chemical method using innovative nanotechnology and advanced processing of biomaterials at various temperatures to control the crystallite size and crystallinity degree. The prepared HAPs were analysed by various physical and chemical methods, like SEM, SEM-EDX, AFM, XRD, TG and DSC analysis. The results showed that these biomaterials both in pastes and in powders contained a unique phase, characterized by the HAP structure, which was substantially preserved even at 1000 oC, indicating a high thermal stability of these biomaterials. To enhance their usage, we have prepared HAP and multi-doped HAPs in the form of pastes with controlled humidity (moisture) and powders with controlled crystallinity, which were lyophilized or lyophilized calcined at 300 oC for 1 h. Preliminary biological tests showed that the adhesion and proliferation of human osteoblasts depended on the heat treatment of HAPs used for building the scaffolds. The findings suggest that these biomaterials based on HAPs may have a wide range of medical applications as bone substitute and coatings on metallic implants.

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Section: Table 2 the Size Of Crystallites And Crystallinity Degree Fosupporting

confidence: 78%

Section: Table 2 the Size Of Crystallites And Crystallinity Degree Fomentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Behavior of Doped Hydroxyapatites During the Heat Treatment

Goga¹,

Forizs²,

Borodi³

et al. 2018

Rev. Chim.

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“…Sr has been shown to stimulate bone formation and decrease bone resorption in both animal studies and clinical trials (Braux et al, ; Neves, Linhares, Costa, Ribeiro, & Barbosa, ). For these reasons, Sr‐substituted HA has attracted considerable interest from researchers and clinicians (Curran, Fleming, Towler, & Hampshire, ; Özbek, Bastan, & Üstel, ; Wong et al, ). It was reported that Sr 2+ can substitute Ca 2+ in a number of CaP phases, including ACP, HA, OCP, and brushite (Rokita, Hermes, Nolting, & Ryzcek, ).…”

Section: Introductionmentioning

confidence: 99%

Strontium substituted biomimetic calcium phosphate system derived from cuttlefish bone

et al. 2019

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Biomimetic triphasic strontium‐substituted calcium phosphate (CaP) powders were prepared by wet precipitation method at 50°C, using CaCO3, (NH2)2COH3PO4, and Sr(NO3)2 as reagents. Calcite was prepared from biogenic source (cuttlefish bone). The synthesized powders have been characterized by elemental analysis, Fourier transform infrared spectrometry, X‐ray diffraction, Rietveld refinement studies and cell viability test. Phase transformation and ion release were analyzed during 7 days of incubation in simulated body fluid at 37°C. The raw precipitated powders were composed of calcium deficient carbonated hydroxyapatite (HA), octacalcium phosphate (OCP), and amorphous calcium phosphate (ACP). After heat treatment at 1200°C β‐tricalcium phosphate (β‐TCP) was detected. Strontium substitution for calcium results in an increase of lattice parameters in HA, OCP, and β‐TCP. Sr2+ occupy the Ca(1) site in HA, Ca(3,4,7,8) sites in OCP and Ca(1,2,3,4) sites in β‐TCP. Along with Sr2+ substitution, presence of Mg2+ and Na+ ions was detected as a result of using biogenic calcium carbonate. The culture of human embryonic kidney cells indicated noncytotoxicity of the prepared CaP powders with emphasis on the cell proliferation during 3 days of culture.

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Microstructures and Properties of Warm-Sprayed Carbonated Hydroxyapatite Coatings

Yao

Chen

et al. 2018

J Therm Spray Tech

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Synthesis and characterization of strontium-doped hydroxyapatite for biomedical applications

Cited by 35 publications

References 41 publications

Behavior of Doped Hydroxyapatites During the Heat Treatment

Behavior of Doped Hydroxyapatites During the Heat Treatment

Strontium substituted biomimetic calcium phosphate system derived from cuttlefish bone

Microstructures and Properties of Warm-Sprayed Carbonated Hydroxyapatite Coatings

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