Pulsed Electromagnetic Fields Accelerate Normal and Diabetic Wound Healing by Increasing Endogenous FGF-2 Release

Callaghan, Matthew J.; Chang, Edward I.; Seiser, Natalie; Aarabi, Shahram; Ghali, Shadi; Kinnucan, Elspeth R.; Simon, Bruce J.; Gurtner, Geoffrey C.

doi:10.1097/01.prs.0000293761.27219.84

Cited by 135 publications

(100 citation statements)

References 34 publications

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“…Injured area significantly decreased in PEMF exposed animals compared to the control groups 49 . This was further supported by Callaghan 50 , et al who evidenced through their findings that PEMF accelerated the overall healing of wounds, particularly during the early stages of tissue repair process (up to 9 days). PEMF exposure improved the histological organization of the wounded tissues resulting in the accelerated and complete reepithelialisation aided by increased skin collagen synthesis after 12 days of PEMF exposure (25 Hz, 2 mT, 8 days, 2.5 h/ day) 45 .…”

Section: Elf-emf and Rattus Norvegicussupporting

confidence: 55%

“…It reduces tissue inflammation (inflammatory phase); increases angiogenesis epithelialisation and neovascular network formation (proliferative phase); accelerates collagen formation, inducing better fiber organisation (remodelling phase) 50,51 . The literature reported so far indicate that the beneficial effects of PEMF in rebuilding the damaged tissue are limited to the subset of low-frequency (3-80 Hz) and intensity (up to a maximum of 20 mT) and anything above this range is reported to have a detrimental effect on the physiology of the animal.…”

mentioning

confidence: 99%

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Advances in Electromagnetic Therapy for Wound Healing

Madduri¹,

Anand²,

Kohli³

et al. 2018

Def. Life. Sc. Jl.

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Understanding the molecular basis of wound healing and tissue regeneration continues to remain as one of the major challenges in modern medicine. Wound healing is a complex procedure involving various cellular mechanism. Though high frequency electromagnetic fields are reported to cause cancer, birth defects and DNA damage, electromagnetic field at low intensity and low frequency can be effectively used for wound healing and for many more medical applications. Low intensity-low frequency pulsed electromagnetic therapy is evidenced to have a significant impact on wound repair and regeneration. It provides a non-invasive reparative technique to treat an injury. In vitro studies reported a significant effect of electromagnetic field on neovascularisation and angiogenesis. There are also many pieces of evidence which support its efficiency in reducing the duration of wound healing and improving the tensile strength of scars. Here, we compared the traditional stigma associated with pulsed electromagnetic fields and weighed them with its potential therapeutic effect on wound healing. Furthermore, emphasised the need for more focused research to determine the therapeutic strategies and optimised parameters of pulsed electromagnetic field that can assure efficient wound healing and regeneration.

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Section: Elf-emf and Rattus Norvegicussupporting

confidence: 55%

mentioning

confidence: 99%

Advances in Electromagnetic Therapy for Wound Healing

Madduri¹,

Anand²,

Kohli³

et al. 2018

Def. Life. Sc. Jl.

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show abstract

“…Local application of the medium to skin flaps created on streptozocin-induced diabetic mice facilitated wound healing and increased its tensile strength. Pulsed electromagnetic fields were also found to prevent ischaemia-associated necrosis [14].…”

Section: Magnetic Field (Magnetotherapy and Magnetostimulation)mentioning

confidence: 99%

Selected physical medicine interventions in the treatment of diabetic foot syndrome

et al. 2016

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The diabetic foot syndrome (DFS) is among chronic complications of diabetes mellitus; it can affect individuals with both type 1 and type 2 diabetes. Diabetic patients have up to a 25% lifetime risk of developing DFS, which is both a medical and social problem. Several studies have indicated that, apart from pharmacotherapy and modern active wound dressings, physical medicine also has a role in prevention and management of diabetic foot ulcers. The paper presents physical medicine interventions most recognized in the conservative management of DFS.

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“…Their potential harmful effects on biological systems, such as leukemia, breast cancer, and cardiovascular disease, are under constant debate [Ahlbom et al, 2008]. In contrast, beneficial effects of LF EMF have been reported, including decreased severity of intestinal lesions in coccidian-infected chickens , accelerated wound healing [Callaghan et al, 2008;Goudarzi et al, 2010] and accelerated bone healing in rats and humans [Grana et al, 2008;Griffin et al, 2008], and augmented response of macrophages to bacterial challenges in humans [Akan et al, 2010]. To date, no mechanism of action has been elucidated, although several possible mechanisms have been suggested, including changes in signal transduction pathways and modulation of oxygen radicals [Liburdy et al, 1993;Blank and Soo 2001;Rollwitz et al, 2004;Frahm et al, 2010].…”

Section: Introductionmentioning

confidence: 99%

Low‐frequency electromagnetic fields do not alter responses of inflammatory genes and proteins in human monocytes and immune cell lines

Bouwens

Kleijn

Ferwerda

et al. 2011

Bioelectromagnetics

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The effects of low frequency electromagnetic fields (LF EMF) on human health are the subject of on-going research and serious public concern. These fields potentially elicit small effects that have been proposed to have consequences, either positive or negative, for biological systems. To reveal potentially weak but biologically relevant effects, we chose to extensively examine exposure of immune cells to two different signals, namely a complex multiple waveform field, and a 50 Hz sine wave. These immune cells are highly responsive and, in vivo, modulation of cytokine expression responses can result in systemic health effects. Using time course experiments, we determined kinetics of cytokine and other inflammation-related genes in a human monocytic leukemia cell line, THP-1, and primary monocytes and macrophages. Moreover, cytokine protein levels in THP-1 monocytes were determined. Exposure to either of the two signals did not result in a significant effect on gene and protein expression in the studied immune cells. Also, additional experiments using non-immune cells showed no effects of the signals on cytokine gene expression. We therefore conclude that these LF EMF exposure conditions are not expected to significantly modulate innate immune signaling. Bioelectromagnetics ß 2011 Wiley-Liss, Inc.

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Pulsed Electromagnetic Fields Accelerate Normal and Diabetic Wound Healing by Increasing Endogenous FGF-2 Release

Cited by 135 publications

References 34 publications

Advances in Electromagnetic Therapy for Wound Healing

Advances in Electromagnetic Therapy for Wound Healing

Selected physical medicine interventions in the treatment of diabetic foot syndrome

Low‐frequency electromagnetic fields do not alter responses of inflammatory genes and proteins in human monocytes and immune cell lines

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