Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture

Androjna, Charlie; Fort, Brian; Zborowski, Maciej; Midura, Ronald J.

doi:10.1002/bem.21855

Cited by 50 publications

(39 citation statements)

References 27 publications

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“…The free radicals can damage DNA and develop harmful cellular responses (6,10). Several studies showed that EMFs could be applied as an antibacterial agent and also utilize as a nonchemical agent for healing or injuring the cells (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the 900 MHz Radiofrequency Radiation Effects on the Antimicrobial Susceptibility and Growth Rate of Klebsiella pneumoniae

et al. 2017

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Introduction: Drug resistance to one or more antibiotics is mainly believed to be a serious threat to global public health which occurs by various mechanisms. The electromagnetic field as a nonchemical tool is capable of altering the antimicrobial susceptibility of bacteria. The aim of this study is the evaluation of the antimicrobial susceptibility of the Klebsiella pneumoniae to antibiotics before and after exposure to 900 MHz radiofrequency (RF) radiation produced by a mobile phone.Methods: Antimicrobial susceptibility of the bacteria to antibiotics disks were performed after exposure to 900 MHz radiofrequency radiation. Antimicrobial susceptibility was carried out by Kirby-Bauer and the inhibition zone of each antibiotic disk was measured (as mean). Additionally, growth variations under exposure were recorded and an outgrowth curve was drawn.Results: Based on the results, after 12 hours of exposure to 900MHz radiofrequency, there was observed a maximum increase in the sensitivity of K. pneumoniae and shown that radiofrequency (RF) radiation can change antimicrobial sensitivity significantly (P < 0.05). Also, the radiofrequency radiation effect on the bacterial proliferation was evaluated and showed that exposure enables the bacteria to grow faster in the exponential phase than the non-exposed bacteria. Conclusions:The findings of the study indicated that the sensitivity of K. pneumoniae was significantly increased to the various antibiotics after 12 hours of exposure to 900 MHz radiofrequency radiation. These observations could be interpreted by the concept of non-linearity in the responses of K. pneumoniae to different antibiotics after exposure to electromagnetic radiofrequency radiation and can be useful in the management of serious infectious diseases.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the 900 MHz Radiofrequency Radiation Effects on the Antimicrobial Susceptibility and Growth Rate of Klebsiella pneumoniae

et al. 2017

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“…Pulsed electromagnetic fields (PEMF) have been proven to present satisfying therapeutic effects on OP experimentally and clinically 9, 12, 37, 38 . However, the potential mechanism responsible for the effects of PEMF on preservation of bone mass are not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…An alternative therapy which is worthy of consideration in the treatment of OP is EMF, which has been investigated as a noninvasive alternative method 8–11 . It has been reported that EMF can increase bone mineral density (BMD) in OP patients 12 , prevent bone loss in OVX induced OP in vivo 9, 13 , and affect bone metabolism in vitro 14 . However, the efficacy of this modality remains uncertain currently 15, 16 .…”

Section: Introductionmentioning

confidence: 99%

Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice

Tao

Liang

et al. 2017

Sci Rep

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Electromagnetic fields (EMF) was considered as a non-invasive modality for treatment of osteoporosis while the effects were diverse with EMF parameters in time domain. In present study, we extended analysis of EMF characteristics from time domain to frequency domain, aiming to investigate effects of four kinds of EMF (LP (1–100 Hz), BP (100–3,000 Hz), HP (3,000–50,000 Hz) and AP (1–50,000 Hz)) on ovariectomized (OVX) osteoporosis (OP) in mice. Forty-eight 3-month-old female BALB/c mice were equally assigned to Sham, OVX, OVX + LP, OVX + BP, OVX + HP and OVX + AP groups (n = 8). After 8-week exposure (3 h/day), LP and BP significantly increased serum bone formation markers and osteogenesis-related gene expressions compared with OVX. Bedsides, LP and BP also slightly increased bone resorption activity compared with OVX, evidenced by increased RANKL/OPG ratio. HP sharply decreased serum bone formation and resporption markers and osteogenesis and osteoclastogenesis related gene expressions compared with OVX. AP had accumulative effects of LP, BP and HP, which significantly increased bone formation and decreased bone resporption activity compared with OVX. As a result, LP, BP and HP exposure did not later deterioration of bone mass, microarchitecture and mechanical strength in OVX mice with OP. However, AP stimulation attenuated OVX-induced bone loss.

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“…Since that time, several studies have been conducted with PEMF with differing results, 49,50 but all favorable to the effect of PEMF. In animal models, increased mineral bone density, 51 increased bone stiffness, 22,52 and more rapid incorporation of bone grafts were observed with the use of PEMF, but no significant improvement was found in the final consolidation rate. 21,23 In a prospective, double-blind, randomized clinical study, Mooney 50 observed a bone consolidation rate of 92% in interbody lumbar arthrodesis surgeries with the use of PEMF versus 65% in the control group.…”

Section: Effect Of Pulsed Electromagnetic Field On the Consolidation mentioning

confidence: 97%

Effect of Pulsed Electromagnetic Field on the Consolidation of Posterolateral Arthrodeses in the Lumbosacral Spine: A Prospective, Double-Blind, Randomized Study

et al. 2017

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Objective: To assess the effect of pulsed electromagnetic field (PEMF) on the consolidation of instrumented lumbar posterolateral arthrodeses in patients who have been surgically treated for degenerative spine disease. Methods: Forty cases were recruited from 163 consecutive patients undergoing lumbar arthrodesis at the same center. The patients were randomized into two groups of 20 patients: Active Group, who were exposed to PEMF for 4 hours a day for 90 days after surgery, and Inactive Group, who received an identical device, with the same instructions for use but without the ability to generate PEMF. The patients underwent computed tomography scans at 45, 90, 180 and 360 days after surgery to check for the occurrence of arthrodesis at each operated spinal level. Results: In the course of the study, two patients were excluded from each group. There were no significant differences between the groups with respect to age, gender, smoking habit, or the number of vertebral levels included in the arthrodesis. The percentage of consolidation of the vertebral levels increased at 90, 180 and 360 days compared to 45 days (p<0.001) in both groups. The Active Group had a 276% greater chance of consolidation in the vertebral levels (OR = 3.76; 95% CI: 1.39-10.20), regardless of the time of evaluation. Patients in the Active Group presented 16% more consolidation than patients in the inactive group (p=0.018). Conclusions: Post-operative exposure to PEMF following instrumented arthrodesis of the lumbar spine for degenerative spine disease increased consolidation in the first year after surgery.Keywords: Randomized controlled trials as topic; Spinal fusion; Spine; Electromagnetic fields; Arthrodesis. (OR = 3,76; IC 95%: 1,20) RESUMO Objetivo: Avaliar o efeito do campo eletromagnético pulsado (CEMP) na consolidação de artrodeses posterolaterais lombares instrumentadas em pacientes que foram tratados cirurgicamente de doença degenerativa da coluna vertebral. Métodos: Quarenta casos foram recrutados de 163 pacientes consecutivos submetidos à artrodese lombar no mesmo centro. Os pacientes foram randomizados em dois grupos de 20 pacientes: Grupo Ativo, que foi exposto a CEMP por 4 horas por dia durante 90 dias após a cirurgia e Grupo Inativo, que recebeu um dispositivo idêntico, com as mesmas instruções de uso, mas sem a capacidade de gerar CEMP. Os pacientes foram submetidos a exames de tomografia computadorizada aos 45, 90, 180 e 360 dias após a cirurgia para verificar a ocorrência de artrodese em cada nível espinhal operado. Resultados: No decorrer do estudo, dois pacientes foram excluídos de cada grupo. Não houve diferenças significativas entre os grupos com relação à idade, sexo, tabagismo ou número de níveis vertebrais incluídos na artrodese. A percentagem de consolidação dos níveis vertebrais aumentou aos 90, 180 e 360 dias em comparação com 45 dias (p < 0,001) em ambos os grupos. O Grupo Ativo teve uma chance de consolidação 276% maior nos níveis vertebrais

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Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture

Cited by 50 publications

References 27 publications

Evaluation of the 900 MHz Radiofrequency Radiation Effects on the Antimicrobial Susceptibility and Growth Rate of Klebsiella pneumoniae

Evaluation of the 900 MHz Radiofrequency Radiation Effects on the Antimicrobial Susceptibility and Growth Rate of Klebsiella pneumoniae

Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice

Effect of Pulsed Electromagnetic Field on the Consolidation of Posterolateral Arthrodeses in the Lumbosacral Spine: A Prospective, Double-Blind, Randomized Study

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