Wave reflection at central arteries consists of a major component of left ventricular afterload. Central augmentation index (AIx) is the most widely used surrogate of wave reflection. Recent technological developments now provide the ability to obtain, non-invasively, aortic, or carotid pressure waves and measure AIx based on various algorithms of pulse wave analysis. The aim of this study was to compare AIx measurements performed by the Arteriograph, Complior, and Mobil-O-Graph apparatuses. Recordings by each device in randomized order were performed with 5-minute interval at 211 individuals (age 55.1 ± 14.1 years, 67.8% males) who underwent diagnostic cardiovascular assessment. All measurements were obtained at the supine position, and AIx was calculated using the formula AIx = 100 × (Augmentation pressure)/(Pulse Pressure). Bland-Altman analysis was performed. Mean difference (bias) ± one standard deviation of difference (with limits of agreement) of AIx between different devices was as follows: (a) Mobil-O-Graph vs Complior: −2.1 ± 14.8% (−31.1% to 26.9%), (b) Arteriograph vs Complior: 12.9 ± 14.6% (−15.7% to 41.5%), and (c) Mobil-O-Graph vs Arteriograph: −10.8 ± 16.9% (−43.9% to 22.3%). The three examined devices exerted significant differences in central AIx estimation which makes the three devices non-interchangeable for wave reflection assessment. However, the Mobil-O-Graph device showed the highest agreement (lowest bias) with the Complior system as regards to the AIx measurement. | 1387 PAPAIOANNOU et Al.Wave reflections depend upon three major factors: (a) the distance to the reflecting site(s), (b) the speed of wave transmission which is predominantly determined by arterial stiffness, and (c) the intensity of the reflected waves. 1,2 Wave reflections are generated in several regions of impedance mismatch (ie, due to arterial diameter or elasticity changes) in the arterial tree. Reflected waves are combined and form a relatively discrete global reflected wave which arrives at the proximal aorta either prematurely, during early systole, leading to a secondary systolic pressure peak and increased central pulse pressure, or delayed during late systole after the systolic pressure peak. 1,3 Augmentation index (AIx), defined as the ratio of the augmentation of SBP to pulse pressure (PP), is the most widely applied surrogate of wave reflection. For its calculation, the merging point of the incident (forward) and the reflected (backward) wave (inflection point) needs to be identified. According to previous observations, 4,5 this inflection point corresponds to the peak of flow velocity and several algorithms have been developed for its identification. 3,4 Nowadays, several commercial devices exist for the non-invasive measurement of central blood pressure and AIx, 6 either directly at the carotid artery (without the use of transfer functions or mathematical model) or indirectly at the aortic level by use of mathematical transformation of peripheral arterial pulses. These apparatuses also use different techniqu...