Pulse methylprednisolone therapy for severe alopecia areata: An open prospective study of 45 patients

Friedli, André; Labarthe, Marie-Christine; Engelhardt, Eliasz; Feldmann, Robert; Salomon, David; Saurat, J.‐H.

doi:10.1016/s0190-9622(98)70009-x

Cited by 113 publications

(120 citation statements)

References 19 publications

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“…In contrast, our data clearly revealed no advantage in the group of patients with long-term AA plurifocalis compared to patients with their first episode of the disease regarding therapy response. Nevertheless, as reported previously by Friedli et al [17], we also observed no effects of corticosteroid pulse therapy in patients with ophiasic AA, AA totalis and AA universalis. In patients with plurifocal AA, however, we observed long-lasting responses with more than 50% regrowth of hair in 10 of 18 patients.…”

Section: Discussionsupporting

confidence: 90%

“…In 1996, Sharma [16]published a study demonstrating hair regrowth in 14 of 24 patients (58%) treated with monthly administrations of high-dose oral corticosteroids. Among other publications a more recent study by Friedli et al [17]including 45 patients also demonstrated that single doses of intravenous methylprednisolone are effective and well tolerated in patients with rapidly progressing extensive plurifocal AA, but not in patients with ophiasic and universal AA [17, 18, 19, 20]. …”

Section: Introductionmentioning

confidence: 99%

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High-Dose Pulse Corticosteroid Therapy in the Treatment of Severe Alopecia areata

et al. 2001

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Objective: The present monocenter prospective study was designed to evaluate the efficacy of intravenous high-dose methylprednisolone pulse therapy in patients with severe alopecia areata (AA). Methods: 30 patients (aged 14–56 years) were treated with methylprednisolone (8 mg/kg body weight) intravenously on 3 consecutive days at 4-week intervals for at least 3 courses. Results: 67% of patients with AA plurifocalis showed >50% regrowth of hair. None of the patients with AA totalis or universalis and only 1 patient with ophiasic AA responded to therapy. In patients with AA plurifocalis, higher response rates could be observed in those suffering from long-term disease compared to patients treated during their first episodes of AA (73 vs. 57%). Conclusion: High-dose methylprednisolone pulse therapy is an effective and well-tolerated treatment for patients with severe AA plurifocalis but might be less beneficial for patients with ophiasic AA, AA totalis or universalis.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

High-Dose Pulse Corticosteroid Therapy in the Treatment of Severe Alopecia areata

et al. 2001

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“…Complete regrowth occurred in 5 patients at the 12-month follow-up. Friedli et al 24 administered 250 mg intravenous methyl prednisolone twice daily on three successive days in 45 patients with rapid and extensive hair loss for less than a year. Patients with multifocal AA showed the best response rate, with 9 (45%), 12 (60%), 13 (65%) and 12 (60%) showing 100% or 50% to 100% regrowth at 1, 3, 6 and 12 months, respectively.…”

Section: Resultsmentioning

confidence: 99%

Medium-dose prednisolone pulse therapy in alopecia areata

Efentaki¹,

Altenburg²,

Haerting³

et al. 2009

Dermato-Endocrinology

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“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Recently, the use of biologics and laser therapy in alopecia areata have shown some beneficial results. [21][22][23] There has been a recent spurt in application of platelet-rich plasma (PRP) in dermatology and aesthetic medicine.…”

Section: Introductionmentioning

confidence: 99%

A clinical study on alopecia areata

Ninama¹,

Mahajan²,

Bilimoria³

et al. 2018

Int J Res Dermatol

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Background: Alopecia areata (AA) is a common auto-immune condition, causing hair loss. This disease has limited treatment modalities. Through this study, comparison between established modalities of treatment such as oral mini pulse therapy, intralesional corticosteroids and platelet-rich plasma (PRP) as a newer modality has been done. The objective of the study was to evaluate the efficacy and safety of various treatment modalities in alopecia areata.Methods: 45 patients with alopecia areata presenting to the OPD of Dermatology, Dhiraj hospital, Pipariya were included in this study. It was conducted as a randomized prospective study for a period of 16 weeks. After taking informed consent, patients were randomly distributed into three treatment groups. Group 1 patients were treated with Tab. Betamethasone 0.1 mg/kg every Saturday and Sunday, Group 2 was treated with Inj. Triamcinolone acetonide 10 mg/ml for scalp and 2.5 mg/ml for eye brows and face was injected into deep dermis; Group 3 was treated with Dermaroller followed by application of activated platelet rich plasma (PRP). SALT score was calculated at first visit and 16 weeks. Regrowth was calculated using Mac Donald and Null Horis grading Scale at 16 weeks.Results: The SALT score reduced from 13.27 to 7.52 in Group 1, 13.93 to 8.16 in Group 2 and 42.32 to 21.12 in Group 3. Mean grade of regrowth of hairs observed was 3.47, 3.80, 2.93 in Group 1, 2, 3 respectively. The results were analysed using paired t test.Conclusions:Intralesional corticosteroids viz. triamcinolone acetonide still remains the first choice of therapy for AA in adults with limited involvement. Systemic corticosteroids give lower response than intralesional steroids. Platelet Rich Plasma (PRP) showed promising results, especially in children and in extensive involvement. Compared to other treatment modalities Inj. PRP is safe and with less side effects.

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Pulse methylprednisolone therapy for severe alopecia areata: An open prospective study of 45 patients

Cited by 113 publications

References 19 publications

High-Dose Pulse Corticosteroid Therapy in the Treatment of Severe Alopecia areata

High-Dose Pulse Corticosteroid Therapy in the Treatment of Severe Alopecia areata

Medium-dose prednisolone pulse therapy in alopecia areata

A clinical study on alopecia areata

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