Abstract:Pulsatile endogenous cortisol secretion is critical for physiological glucocorticoid gene signaling. Conventional glucocorticoid replacement therapy does not mimic endogenous cortisol pulsing in primary adrenal insufficiency. In an open-labelled, two-week, non randomized cross-over study of five patients with adrenal insufficiency (Addison’s disease in two, bilateral adrenalectomy in one and congenital adrenal hyperplasia in two patients) we compared pulsatile and continuous cortisol pump treatment and conven… Show more
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