Pulsatile ocular blood flow: relationship with flow velocities in vessels supplying the retina and choroid

Zion, Itay Ben; Harris, Alon; Siesky, Brent; Shulman, Shiri; McCranor, L.; Garzozi, Hanna J.

doi:10.1136/bjo.2006.108340

Cited by 32 publications

(28 citation statements)

References 18 publications

(19 reference statements)

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“…In such a case, a lower pulse amplitude at greater axial lengths would not necessarily imply reduced blood flow velocities within the retrobulbar bed, but it might be affected by variations in blood velocity at the central retinal artery. The work cited above by Zion and co-workers described a similar correlation between POBF and the central retinal artery pulse, which supports our findings [34].…”

Section: Discussionsupporting

confidence: 92%

“…Several significant correlations resulted from the multivariate model, such as those between the pulsatile blood flow with the central retinal artery and ophthalmic artery blood velocities. Similar associations have been described in the past [34], and it has been suggested that the pulsations of the retrobulbar retinal circulation influence the POBF recordings. Correcting for the effect of axial length on the interactions between the three vascular beds resulted in the same correlations, with the exception of those between pulse amplitude and the ophthalmic artery, which did not exhibit any significance.…”

Section: Discussionmentioning

confidence: 54%

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Ocular blood flow measurements in healthy human myopic eyes

Benavente-Perez

Hosking

Logan

et al. 2010

Graefes Arch Clin Exp Ophthalmol

104

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High myopes exhibited significantly reduced pulse amplitude and CRA blood velocity, the first of which may be due to an OBF measurement artefact or real decreased ocular blood flow pulsatility. Axial length and refractive error correlated moderately with the ocular pulse and with the resistance index of the CRA, which in turn correlated amongst themselves. It is hypothesized that the compromised pulsatile and CRA haemodynamics observed in young healthy myopes is an early feature of the decrease in ocular blood flow reported in pathological myopia. Such vascular features would increase the susceptibility for vascular and age-related eye diseases.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 54%

Ocular blood flow measurements in healthy human myopic eyes

Benavente-Perez

Hosking

Logan

et al. 2010

Graefes Arch Clin Exp Ophthalmol

104

View full text Add to dashboard Cite

show abstract

“…Low wall filter settings were used. To examine the OA, the sample volume was oriented nasally and superior to the optic nerve, OA is just lateral to and abuts the visible hyporeflective stripe representing the nerve, while the central retinal artery (CRA) was imaged in the shadow of the optic nerve, the sample volume was placed about 3 mm behind the surface of the optic disc 14. The Peak Systolic Velocity (PSV) and End Diastolic Velocity (EDV) values were obtained by taking the velocity reading at the peak of the spectral wave pattern and that at the wavetrough, respectively.…”

Section: Methodsmentioning

confidence: 99%

Ocular blood flow velocity in primary open angle glaucoma - A tropical african population study

Adeyinka

Olugbenga

Helen

et al. 2013

Middle East Afr J Ophthalmol

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Purpose:To assess blood flow velocity in newly diagnosed indigenous black-skinned Africans with primary open angle glaucoma (POAG).Materials and Methods:Prospective case-control study at Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria on 50 newly diagnosed POAG patients (POAG group) and 50 control patients (control group). Ocular Doppler Color Imaging was performed on subjects in the supine position using 9 MHz linear array transducer of a Fukuda Denshi Ultrasound. The Peak Systolic Velocity (PSV) and End Diastolic Velocity (EDV) values were obtained by finding the average of two readings each for the ophthalmic artery (OA) and central retinal artery (CRA). Resistive Index (RI) was calculated as (PSV − EDV)/PSV. Data were analyzed and statistical significance was defined at P < 0.05.Results:The mean intraocular pressure (IOP) for the POAG group and control group was 28.1 ± 7.4 mmHg and 16.6 ± 2.0 mmHg, respectively (P < 0.001). The mean PSV for OA was 31.35 cm/s in POAG group and 37.61 cm/s for the control group (P < 0.001). The EDV for both OA and CRA were significantly lower in glaucoma patients as compared with the corresponding values in the control group (P < 0.001, both comparisons). The mean RI in the OA was 0.71 ± 0.05 and 0.63 ± 0.03 for the POAG and control group groups, respectively (P < 0.001). The increase in IOP in the POAG group was statistically significantly negatively correlated with PSV and EDV and positively correlated with RI for both OA and CRA.Conclusion:The outcomes of this study indicate that ocular blood flow alterations including reductions in PSV and EDV and increase in RI of the OA and CRA are present in black-skinned Africans with POAG.

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“…The bolus of blood entering the choroidal vasculature during systolic and diastolic phases transmits pressure to the anterior segment of the eye, affecting the OPA (Langham & To’Mey 1978; Silver & Farrell 1994). Recently, the pulsatility index of the choroidal vasculature was found to be strongly associated with OPA as measured by colour Doppler imaging (Zion et al. 2007).…”

Section: Introductionmentioning

confidence: 99%

Factors affecting ocular pulse amplitude in eyes with open angle glaucoma and glaucoma‐suspect eyes

Choi

Lee

Park

et al. 2012

Acta Ophthalmologica

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ABSTRACT.Purpose: To investigate the associations between ocular pulse amplitude (OPA) as measured by dynamic contour tonometry (DCT) and ocular and systemic factors in patients with open angle glaucoma (OAG) and in glaucoma suspects. Methods: One hundred and seventy-three glaucoma-suspect patients were consecutively enrolled. All subjects underwent intraocular pressure (IOP) measurement by DCT and Goldmann applanation tonometry (GAT), OPA measurement by DCT, Humphrey visual field (HVF) examination and central corneal thickness measurements. Arterial pulse amplitude (APA) and ocular perfusion pressure (OPP) were defined as the difference between systolic and diastolic BP and the difference between mean arterial pressure and IOP, respectively. All subjects also completed a systemized questionnaire on systemic vascular morbidities. Results: Seventy-four eyes were diagnosed with OAG, based on HVF results. The overall mean CCT was 538.2 ± 37.6 lm. In all 173 eyes, OPA was associated with spherical equivalent (SE, p < 0.001) and with IOP by GAT (p = 0.013) by multivariate analysis. Multivariate analysis of the 77 subgroup eyes of patients for whom BP parameters were available also revealed that OPA was associated with SE (p = 0.007) and with IOP by GAT (p < 0.001). When the subjects were classified into the groups with low, intermediate and high cardiovascular risk based on the questionnaire, there was no difference in OPA among these groups (p > 0.05). Conclusions: Ocular pulse amplitude was associated with IOP measured by GAT and SE in patients with OAG and in glaucoma suspects. There was neither significant correlation between systemic hemodynamic parameters and OPA, nor difference of OPA in patients with different cardiovascular risk. OPA is primarily a measure of pressure, and there are certain limitations towards its use as a hemodynamic index.

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Pulsatile ocular blood flow: relationship with flow velocities in vessels supplying the retina and choroid

Abstract: POBF is associated with systolic and pulsatile components of blood flow velocities in both the CRA and the TSPCA. This result suggests that POBF determinations are influenced by the pulsatile components of both choroidal and retinal perfusion.

Cited by 32 publications

References 18 publications

Ocular blood flow measurements in healthy human myopic eyes

Ocular blood flow measurements in healthy human myopic eyes

Ocular blood flow velocity in primary open angle glaucoma - A tropical african population study

Factors affecting ocular pulse amplitude in eyes with open angle glaucoma and glaucoma‐suspect eyes

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