Ocular blood flow measurements in healthy human myopic eyes

Benavente-Perez, Alexandra; Hosking, Sarah; Logan, Nicola S; Broadway, David C

doi:10.1007/s00417-010-1407-9

Cited by 103 publications

(92 citation statements)

References 40 publications

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“…Decreases in blood flow in highly myopic eyes have been reported for both retrobulbar and retinal microvasculature. 5,24,26 Furthermore, using ultrawide fluorescein angiography, Hollo et al 23 identified a larger nonperfused zone in the far retinal periphery of highly myopic eyes. This nonperfused area may be caused by retinal stretching, which may further exacerbate peripheral retina thinning.…”

Section: Discussionmentioning

confidence: 99%

“…Retinal micro-and large vessels OCTA Density decrease Benavente-Perez et al 5 2010 Retrobulbar microvessels Color Doppler Heidelberg retinal flowmetry CRA blood velocity decrease. Capillary blood parameters no change Chueng et al 22 2007 Retinal vascular caliber Retinal photographs No change Shimada et al 24 2004…”

Section: Present Study 2016mentioning

confidence: 99%

“…3,4 Previous studies have focused on the relationship between high myopia and large retinal vascular changes. Using color Doppler imaging, Benavente-Perez et al 5 demonstrated a pulse amplitude reduction in the central retinal artery of highly myopic eyes. With a fundus camera and fractal analysis, Azemin et al 6 analyzed the retinal vessels in moderate to high myopia and found a density reduction in the large retinal vessels of myopic eyes when compared with emmetropic eyes.…”

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confidence: 99%

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Retinal Microvasculature Alteration in High Myopia

Wang

Jiang

et al. 2016

Invest. Ophthalmol. Vis. Sci.

124

100

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PURPOSE. To investigate the retinal vascular network alterations in highly myopic eyes.METHODS. Thirty-three highly myopic eyes from 21 subjects and 47 mildly myopic or emmetropic eyes from 24 healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) was used to image the superficial, deep, and whole retinal vascular plexuses at the macular region. Highly myopic eye images were analyzed after adjusting the ocular magnification using Bennett's formula. Fractal analysis (box counting method, D box ) representing vessel density was performed in different annular and quadrantile zones of both large vessels and microvessels. Correlations between the vascular density, axial length, and spherical equivalent refractive error were analyzed. RESULTS.The average density (D box ) of the superficial retinal annular zone (0.6-2.5 mm) microvessels was 1.741 6 0.018 in highly myopic eyes and was shown to be significantly lower than that of the controls (1.773 6 0.010, P < 0.001). Individual annular zone (bandwidth of 0.16 mm) analysis of highly myopic eyes revealed a significant level of microvessel alteration in all zones compared with the same zones in control eyes (P < 0.001). Furthermore, in the highly myopic group, the microvessel density was significantly correlated with axial length elongation in all three layers (r ¼ À0.38 to À0.48; P < 0.05).CONCLUSIONS. This study reveals retinal microvascular network alterations in highly myopic eyes, which correlates with axial length elongation. Fractal analysis of the microvasculature by OCTA images may help to characterize the underlying pathophysiological mechanisms involved in high myopia.

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Section: Discussionmentioning

confidence: 99%

Section: Present Study 2016mentioning

confidence: 99%

mentioning

confidence: 99%

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Retinal Microvasculature Alteration in High Myopia

Wang

Jiang

et al. 2016

Invest. Ophthalmol. Vis. Sci.

124

100

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“…Alterations in ocular shape, as it occurs for example in myopia, are often associated with vascular abnormalities [5,34,42] and with higher risks of severe ocular conditions, such as glaucoma [18,30], retinal detatchment [32,50] and maculopathy [17,27]. Architectural changes in the retinal vasculature are also often associated with ocular diseases, including glaucoma [22,29,46,48], diabetic retinopathy [9,8,24] and myopia [16,31].…”

Section: Introductionmentioning

confidence: 99%

Effect of ocular shape and vascular geometry on retinal hemodynamics: a computational model

Dziubek

Guidoboni

Harris

et al. 2015

Biomech Model Mechanobiol

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Thistleton, W. (2016Effect of ocular shape and vascular geometry on retinal hemodynamics: a computational modelReceived: date / Accepted: date Abstract A computational model for retinal hemodynamics accounting for ocular curvature is presented. The model combines: (i) a hierarchical Darcy model for the flow through small arterioles, capillaries and small venules in the retinal tissue, where blood vessels of different size are comprised in different hierarchical levels of a porous medium; and (ii) a one-dimensional network model for the blood flow through retinal arterioles and venules of larger size. The non-planar ocular shape is included by: (i) defining the hierarchical Darcy flow model on a two-dimensional curved surface embedded in the three-dimensional space; and (ii) mapping the simplified one-dimensional network model onto the curved surface. The model is solved numerically using a finite element method in which spatial domain and hierarchical levels are discretized separately. For the finite element method we use an exterior calculus based implementation which permits an easier treatment of non-planar domains. Numerical solutions are verified against suitably constructed analytical solutions. Numerical experiments are performed to investigate how

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“…Their study included a comparison between PRP cases and non-PRP cases (7). However, POBF values can be affected by individual demographic factors such as age, sex, IOP, corneal thickness, refraction error, and systemic hypertension (22)(23)(24)(25)(26)(27). Hence, this study was designed to evaluate the possible impact of PRP on POBF.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy

Verma

Verma²

2014

Turk J Med Sci

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Although for ultrabasic and basic magmas a plethora of tectonomagmatic diagrams have been used, with the exception of one bivariate diagram for refined tectonic setting of orogenic andesites, none is available for highly abundant intermediate magma.We present 3 sets of discrimination diagrams obtained from the correct statistical methodology of log e -ratio transformation and linear discriminant analysis. All major element log e -ratio variables in 3664 samples, only immobile major and trace element log e -ratio variables in 1858 samples, and immobile trace element log e -ratio variables in 1512 samples were used. These diagrams with probability-based tectonic field boundaries and high success rates (about 69%-96%, 63%-100%, and 64%-100%, respectively, for diagrams based on all major elements, immobile major and trace elements, and immobile trace elements) were first tested for fresh and highly altered rocks. The expected tectonic setting was indicated from our diagrams. The probability-based decisions and total percent probability estimates can fully replace the actual plotting of samples in the diagrams. The probability calculations were then used for tectonic discrimination of 7 case studies of Archean to Proterozoic rocks. An island arc setting was indicated for the Wawa greenstone belt (Canada), implying the existence of plate tectonic processes during the Late Archean, for western Tasmania (Australia) during the Cambrian, and for Chichijima Island (Bonin Islands, Japan) during the Eocene. Similarly, an arc setting (indecisive island or continental type) was obtained for south-central Sweden during the Paleoproterozoic and for Adola (southern Ethiopia) during the Neoproterozoic. A within-plate setting was inferred for the Neoproterozoic Malani igneous complex, Rajasthan, India. A collision setting was indicated for the Alps (France-Italy-Switzerland) during the Late Carboniferous. Modeling of likely as well as extreme processes indicates that these diagrams are robust against postemplacement compositional changes caused by analytical errors, element mobility, Fe-oxidation, alteration, and petrogenetic processes.

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Ocular blood flow measurements in healthy human myopic eyes

Cited by 103 publications

References 40 publications

Retinal Microvasculature Alteration in High Myopia

Retinal Microvasculature Alteration in High Myopia

Effect of ocular shape and vascular geometry on retinal hemodynamics: a computational model

Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy

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