Pulsatile Mechanical Circulation, Physiology, and Pump Technology

Copeland, Jack G.; Copeland, Hannah

doi:10.1007/978-3-030-47809-4_17

Cited by 2 publications

(3 citation statements)

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“…Copeland et al believed that the surplus hemodynamic energy of a pulsatile pump is much higher than that of a continuous pump [11]. The extra energy of each pulse seems to be an advantage.…”

Section: Introductionmentioning

confidence: 99%

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Making a Soft Elastic Pulsation Pump (SEPP)

Xia

Zhang

et al. 2023

Processes

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In this work, a soft-elastic pulsation pump (SEPP) has been made and investigated. Here, 3D printing was used to make casting molds and a melt-removal method using wax was employed. The SEPP was made of silicone rubber and driven by an external squeezing mechanism. A silicone one-way valve was also made which prevented backflow after the fluid was squeezed out of the pump chamber. The material characteristics of the SEPP including durability were examined. The pump operating parameters were confirmed to differential pressure of 100 mm Hg in a close flow loop. The average flow rate was 2 L/min, while yielding a peak flow of 8 L/min, and a stroke volume of 70 mL. A preliminary trial using fresh animal blood had shown that the SEPP has good protection on the blood. Therefore, within the resources available, an interesting idea for an effective SEPP has been proposed and realized in the laboratory. The technical details of the SEPP described, and the experimental results reported here form a good basis for making higher capacity SEPPs. This effort may help make its way to an effective ventricular assist device.

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Section: Introductionmentioning

confidence: 99%

“…The extra energy of each pulse seems to be an advantage. As physiological conditions change, the microcirculation may require this additional energy to maintain adequate capillary flow [11]. Sunagawa et al suggested that the use of pulsatile flow improves end-organ function compared to non-pulsatile flow [12].…”

Section: Introductionmentioning

confidence: 99%

Making a Soft Elastic Pulsation Pump (SEPP)

Xia

Zhang

et al. 2023

Processes

View full text Add to dashboard Cite

show abstract

“…As mechanical circulatory support evolves, pulsatility has emerged as an important issue. 16 Lower pulsatility in LVADs is related to gastrointestinal bleeding and other adverse events. One trend in LVAD therapy development is to return to pulsatile flow.…”

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confidence: 99%

“It Works.” Every heart transplant program should have one

Copeland

2022

Journal of Cardiac Surgery

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The total artificial heart (TAH) provides full biventricular cardiac replacement, pulsatile perfusion at flows of 7-9 L/min at low filling pressures. This allows organs that are failing to recover and for the potential cardiac recipient to become a better transplant candidate. Postimplant patients are mobile and able to go through physical rehabilitation in a hospital or at home. The risks are acceptable as shown by the authors. TAH use in more transplant centers could save lives in many transplant candidates. K E Y W O R D S transplant "Trends and outcomes following total artificial heart (TAH) as a bridge to transplant from the UNOS database" by Coyan et al. reports on 433 total artificial heart bridge to transplant (BTT) patients from 2004 to 2020. This experience was with the SynCardia TAH-t. Coyan et al. found waitlist mortality of 7.4% and that 86.6% of implanted waitlist patients were transplanted. One-year posttransplant survival was 80%. The outcomes are similar to those reported in 2004 in a muti-institutional study that led to FDA approval for the bridge to transplantation in the United States of the Syn-Cardia TAH-t. 1 In the FDA study, 79% of all study TAH recipients were transplanted, and 1-and 5-year survivals posttransplantation How to cite this article: Copeland JG, Copeland H. "It Works." Every heart transplant program should have one.

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Pulsatile Mechanical Circulation, Physiology, and Pump Technology

Cited by 2 publications

References 72 publications

Making a Soft Elastic Pulsation Pump (SEPP)

Making a Soft Elastic Pulsation Pump (SEPP)

“It Works.” Every heart transplant program should have one

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