Pulpal Inflammation and Incidence of Coronary Heart Disease

Joshipura, Kaumudi; Pitiphat, Waranuch; Hung, Hsin-Chia; Willett, Walter C.; Colditz, Graham A.; Douglass, Chester W.

doi:10.1016/j.joen.2005.10.039

Cited by 83 publications

(84 citation statements)

References 14 publications

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“…35 The association between inflammation of endodontic origin and systemic health has not been adequately reported in the scientific literature. 36,37,38 The available scientific evidence is limited, but it is consistent in suggesting that AP may contribute to a systemic immune response that is not confined to the localized lesion, potentially leading to increased systemic inflammation. 39 Chronic apical periodontitis has been independently associated with coronary heart disease (CHD), 38 and surgical endodontic treatment has been demonstrated to reduce systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological evaluation of apical periodontitis prevalence in an urban Brazilian population

et al. 2015

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The present study aimed to assess the prevalence of apical periodontitis (AP) in an urban Brazilian population according to gender, age group and tooth type. Data were collected from clinical files containing the medical and dental histories and periapical radiographs of 1,126 patients treated at the School of Dentistry at Universidade do Estado do Rio de Janeiro between March 2000 and December 2010. A total of 15,724 periapical radiographs were evaluated. All the radiographs were evaluated by two independent, previously calibrated endodontists (kappa = 0.88). Periapical areas on the radiographs were classified as N (normal) or AR (apical radiolucency). The frequency of AP and the 95% Confidence Interval (95%CI) were calculated according to gender, age group and tooth type. Differences between groups were calculated using the Z-test at a significance level of 5% (p < 0.05). AP was present in 7.87% of the samples, with 16.70% occurring on previously endodontically treated teeth and 44.65% occurring on teeth referred for endodontic treatment (TR-RCT). The frequency of AP was higher among females (64%) than among males (35%). The central and lateral maxillary incisors were the most frequently affected teeth. The frequency of AP was higher among individuals between 30 and 49 years of age. In this population, AP was more prevalent among females and among individuals between 30 and 49 years of age, and the central and lateral maxillary incisors were the most frequently affected teeth.

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Section: Discussionmentioning

confidence: 99%

Epidemiological evaluation of apical periodontitis prevalence in an urban Brazilian population

et al. 2015

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“…Dental caries is associated with such adverse health conditions as cardiovascular disease, asthma, liver disease, and poor growth (Acs et al 1999;Glodny et al 2013;Johnston and Vieira 2014). Periodontal disease and dental caries may be causally related to diseases such as cardiovascular disease, cancer, and respiratory infections by affecting systemic inflammatory cytokine levels and via the spread of infectious pathogens from the oral cavity to other parts of the body (Beck and Offenbacher 2005;Joshipura et al 2006;Lombardo Bedran et al 2013;Loos 2005;Meyer et al 2008;Paju and Scannapieco 2007;Watts et al 2008). The two conditions and their association with other health problems also might reflect other underlying risk factors, such as compromised immune responses (Acs et al 1999;Michaud et al 2008).…”

Section: Advances In Our Understanding Of Lesion-formation Processesmentioning

confidence: 99%

The Osteological Paradox 20 Years Later: Past Perspectives, Future Directions

2015

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More than 20 years ago, Wood et al. (Curr Anthropol 33:343-370, 1992) published ''The Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,'' in which they challenged bioarchaeologists to consider the effects of heterogeneous frailty and selective mortality on health inferences in past populations. Here, we review the paper's impact on bioarchaeology and paleopathology, focusing on recent advancements in studies of ancient health. We find the paper is often cited but infrequently engaged in a meaningful way. Despite an initial decade of limited progress, numerous researchers are now addressing components of the Paradox in more informed ways. We identify four areas of fruitful research: (1) intrasite, contextual perspectives, (2) subadults, (3) associating stress markers with demographic phenomena, and (4) skeletal lesion-formation processes. Although often seen as a problematic assumption, understanding the sources of heterogeneous frailty within human populations is a worthy research question in and of itself, and one that clearly links past and present health research within a global framework.

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“…Using data from the Health Professionals Follow-Up Study (HPFS), with its large cohort of 34,683 participants, Joshipura et al [55] evaluated the connection between pulpal inflammation and incidence of CHD. The hypothesis to be tested was that pulpal inflammation may lead to increased CHD risk.…”

Section: Apical Periodontitis (Endodontic Infection) and Chdmentioning

confidence: 99%

“…The issue has been addressed only recently and has produced mixed results, with studies in favor of a positive correlation between apical periodontitis and coronary risk [40,59], and other negative [47,58] or inconclusive [55]. Unfortunately, the necessary scientific rigorousness was not always applied for a better understanding of the relationship between the presence of periapical lesions and CV risk.…”

Section: Conclusion On the Correlation Between Apical Periodontitis mentioning

confidence: 99%

“…By bivariate logistic regression: association between endodontically treated teeth and CHD; no association between teeth with AP and CHD Caplan et al [40] 708 male participants in the VADLS a Possible link between number of lesions of AP and CHD Higher relationship between AP and development of CHD (especially in young age group) Joshipura et al [55] 34,683 participants from HPFS b Possible association between pulpal inflammation (endodontic treatment) and incidence of CHD Strong association between a positive self-reported history of Endodontic Treatment incidence of CHD Frisk [58] 3499 women participants from the PSWG c and random samples of dentate individuals (n 2066) aged 20-70 years from the PSOHJ d Endodontic status in Swedish populations and possible association between AP and CHD No significant association between AP and CHD and socio-economic risk factors and AP respectively.…”

Section: Authors Year Participantsmentioning

confidence: 99%

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