Pulmonary tuberculosis specificities in smokers

Aziza, Rhanim; Hammi, S.; Kouismi, Hatim; Bourkadi, Jamal Eddine

doi:10.1016/j.ejcdt.2015.04.011

Cited by 3 publications

(6 citation statements)

References 9 publications

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“…In this study, the weight of the patients after two months of anti TB treatment was found to increase from the weight at the start of treatment as; approximate weight gain of 2 kg in non-smoker 57.16%, current smokers 49.5% 1.9 kg and 50.38% 2 kg in ex-smokers. This finding is covered by a study done by Aziza R et al [16] as according clinical assessment there was 91.1% patients of TB (non-smokers) showed weight gain between 2 to 5 kg in contrast to in 35.3% of smokers. After 6 months of treatment, the nonsmoker group experienced more weight gain (63.83±6.92 6 kg than smokers and exsmokers (mean 5 kg weight gain (55.47±5.19 5 kg, 54.10±7.67 6 kg respectively), indicating more positive outcome of anti TB treatment in nonsmoker group of this study.…”

Section: Discussionmentioning

confidence: 77%

“…These lesions healed significantly in nonsmokers (93.75%) after 2-6 months of treatment but only 75% smokers and 88.75% exsmokers showed healed scars. Aziza R et al [16] in their study also concluded that the smoker subjects had more generalized lesions as compared to nonsmokers who had only one type of lung lesion after 2-6 months of treatment. We performed Gene Xpert method for diagnosis of TB in our 3 groups of 80 Subjects each.…”

Section: Discussionmentioning

confidence: 86%

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Comparison of Anti-Tuberculosis Treatment Outcomes of Pulmonary Tuberculosis in Current, Ex and Non Smokers

Talpur¹,

Kumar²,

Abbass³

et al. 2020

JPRI

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Objective: To detect treatment outcomes in current smokers, ex - smokers and nonsmokers, in newly diagnosed pulmonary TB patients. Methodology: This cohort prospective study was conducted in the department of Microbiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre Karachi, with the collaboration of different (DOTS) centers of Pathology Karachi Medical and Dental College, Karachi. All newly diagnosed pulmonary TB patients registered for treatment either of gender were included. The patients were divided into three groups. Group-A: Current smokers, Group-B: Ex-smokers, Group-C: Non-smokers. Patients were followed for 6 months. Outcome was assessed in terms of cured or failure. All the information was enrolled in pre-designed proforma. Data was analyzed by using SPSS version 20. Results: In current study mean age of non-smokers was 44.20±17.73, ex-smokers 43.13±15.67 years mean age of smokers was 38.07±15.67 years. Males were in majority in all study groups as in ex-smokers group, males were 98.75%, non-smoker males were 90.0% and in smoker group males were 92.50%. At starting of treatment, mean weight of smoker patients was 55.50±5.41 kg, ex-smoker’s 48.91±9.00 kg and mean weight of non-smokers 48.71±7.04 kg. P-0.001. At starting of treatment, the mean ESR of non-smokers was 89.31±10.02, ex-smoker’s was 82.62±12.18 and smokers ESR average was 80.61±15.83. P-0.001. After 6 month treatment, cured rate was (96.25%) in non-smokers, (90%) in smokers and (93.75%) in ex–smokers. Conclusion: This study concluded that cured rate was high in non-smokers. Smoking status in individuals greatly affects the tuberculosis treatment outcome with enhance failure rate.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 86%

Comparison of Anti-Tuberculosis Treatment Outcomes of Pulmonary Tuberculosis in Current, Ex and Non Smokers

Talpur¹,

Kumar²,

Abbass³

et al. 2020

JPRI

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“…This study is in accordance with the study of Aziza R, et al 2015. 10 Among the total of 29 extrapulmonary tuberculosis patients in the study, 17 (58.62%) were smokers and 12 (41.37%) were non-smokers. Though, EPTB is documented more in smokers as compared to non-smokers yet the association of EPTB with smoking is not statistically significant.…”

Section: Spirometric Findingsmentioning

confidence: 88%

“…In the study, 77.08% of smokers showed obstructive pattern against the 20% of nonsmokers. 10 with 104 tuberculosis patients where the male to female ratio was 3.72. The age of patients ranges from minimum of 18 years to a maximum of 67 years with a mean±SD of 40.5±13.2 years, which corroborates with other studies.…”

Section: Smoker With Ptb(n=78)mentioning

confidence: 99%

“…The age of patients ranges from minimum of 18 years to a maximum of 67 years with a mean±SD of 40.5±13.2 years, which corroborates with other studies. 11,10 Maximum numbers of patients in smoker group are found in age between 41-50, i.e., 36.84%, while in non-smoker group, the maximum numbers of patients are in age group of 21-30, i.e., 67.56%, which is quite similar to the study conducted by Agarwal A, et al (2011) 12 with 120 patients where the maximum number of patients who was smoker with tuberculosis is between 41-50 years, i.e., 30.76% and the maximum number of patients who were non-smoker with tuberculosis is between 31-40 years, i.e., 25.71%. In this study, AFB in sputum 3+ is found more among smokers with PTB as compared to non-smokers with PTB (58.97% vs 12%) and is statistically significant (p <0.0001).…”

Section: Smoker With Ptb(n=78)mentioning

confidence: 99%

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Clinico-Radiological Profile of Tuberculosis Among Smokers Attending RNTCP Facility at Gauhati Medical College and Hospital, Guwahati

Singha¹,

Baruah²,

Phukan³

2016

jebmh

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BACKGROUND Tobacco smoking is one of its major predisposing factor of Tuberculosis (TB), which has proved to be a major health problem in developing countries. OBJECTIVES This study aims to assess the impact of smoking on Pulmonary TB (PTB) and its association with Extrapulmonary TB (EPTB). MATERIALS AND METHODS This study is a one year hospital-based observational study comprising of 132 patients who were diagnosed TB based on clinical features and diagnostic algorithm given in RNTCP guidelines and fulfilled the inclusion and exclusion criteria. History of smoking was taken as per predesigned questionnaire. Follow up for smear conversion at 2 months and spirometric evaluation at the end of treatment was done. Statistical analysis was done using GraphPad InStat for Windows 7. RESULTS AND OBSERVATION This study shows Acid-Fast Bacilli (AFB) 3+ in sputum more among smokers with PTB as compared to non-smokers with PTB (58.97% vs 12%, p <0.0001). PTB patients who smoke suffer more from dyspnoea (p <0.0001) and have severe radiological lesions like cavities and fibrosis (p <0.0001) with bilateral and multizonal involvement as compared to non-smokers. Though EPTB is also documented more in smokers as compared to nonsmokers yet it is not statistically significant. Delay in smear conversion on treatment follow up is found significant among smokers (p <0.009) and most of the smokers landed with obstructive pattern (77.08%) as sequelae. CONCLUSION This study reveals an aggravated clinico-radiological course with a higher sputum smear grading for AFB and delay in smear conversion amongst smokers with PTB. EPTB is also found more in smokers as compared to nonsmokers. An association of smokers suffering from PTB and frequent impairment in lung function has been demonstrated by spirometry and this area particularly needs to be focussed.

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Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort

et al. 2022

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Pulmonary tuberculosis specificities in smokers

Cited by 3 publications

References 9 publications

Comparison of Anti-Tuberculosis Treatment Outcomes of Pulmonary Tuberculosis in Current, Ex and Non Smokers

Comparison of Anti-Tuberculosis Treatment Outcomes of Pulmonary Tuberculosis in Current, Ex and Non Smokers

Clinico-Radiological Profile of Tuberculosis Among Smokers Attending RNTCP Facility at Gauhati Medical College and Hospital, Guwahati

Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort

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