Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which currently has a high incidence worldwide. Based on the incidence and mortality data of tuberculosis in 31 provinces in Chinese mainland from 2015 to 2019, this paper analyzes and studies the spatial agglomeration and local accumulation effects of tuberculosis incidence in China. Studies show that there is an obvious seasonal trend in the transmission of tuberculosis.The incidence peaks in March each year after the bottom in February. In addition, the tuberculosis incidence shows obvious spatial agglomeration, with a relatively high incidence rate in Xinjiang, Tibet, Qinghai, Guizhou, etc., while a low incidence rate in Beijing, Tianjin, Shanghai, Shandong, Jiangsu, Zhejiang, etc. Overall, the incidence has a clear upward trend from east to west, and the incidence rate in inland areas is higher than that in coastal areas. In addition, the paper also considers other factors that contribute to high-frequency transmissions, such as bad climate, poor air quality, and an underdeveloped economy. The most influential factor to the tuberculosis incidence is economic development level, and poor air quality in the northwest and southwest regions is also important reason for the high tuberculosis incidence.