Pulmonary tuberculosis presenting with acute respiratory distress syndrome (ARDS): A case report and review of literature

Raina, Adnan; Bhat, Abid; Bhat, Fayaz Ahmad; Changal, Khalid; Dhobi, Ghulam Nabi; Koul, Parvaiz A; Raina, Manzoor Ahmad; Wani, Feroz Ahmad

doi:10.1016/j.ejcdt.2013.09.008

Cited by 9 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The endotoxin, the activation of the complement, the cytokines, the arachidonic acid's metabolites, liposomal enzymes and kinines, histamine, the nitric oxide or the mediators derived from the endothelium, are the aggressive participants in the decompensation of the patient's clinical status. The complications arise together with micro-embolisms, pulmonary artery hypertension and the alteration of the respiratory functions [41][42][43][44][45][46][47][48]. Neutrophils stimulation through different biochemical mechanisms produces high quantities of hydrogen peroxide [49][50][51].…”

Section: Biochemical Aspects Of Free Radicals and The Actions Of Oxidmentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

View full text Add to dashboard Cite

Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.

show abstract

Section: Biochemical Aspects Of Free Radicals and The Actions Of Oxidmentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

View full text Add to dashboard Cite

show abstract

“…Tuberculosis (TB) is the seventh-leading cause of death in the world, and pulmonary TB is, by far, the most common presentation of this infection.1 Usually, pulmonary TB presents as chronic pneumonia, with approximately 4 weeks between symptom onset and the first health consultation.2 The reported frequency of acute respiratory failure in patients with active TB ranges from 1.5-5%. 3 , 4 The presentation ranges from acute respiratory failure in miliary TB to acute respiratory distress syndrome (ARDS).3 Agrawal et al 4 reported that up to 4.9% of TB cases presented as ARDS in India, and in 22% of these cases, ARDS occurred after treatment for miliary TB. 4 - 6 Kingdom of Saudi Arabia (KSA) is an intermediate-risk country for TB.…”

mentioning

confidence: 99%

Acute respiratory distress syndrome complicating community-acquired pneumonia secondary to mycobacterium tuberculosis in a tertiary care center in Saudi Arabia

Mahmoud

Baharoon

Alsafi

et al. 2016

SMJ

View full text Add to dashboard Cite

Objectives:To discuss our center’s experience with acute respiratory distress syndrome (ARDS) secondary to pulmonary tuberculosis (TB) in a major tertiary referral hospital in the Kingdom of Saudi Arabia.Methods:A retrospective review of medical records of all patients with community-acquired pneumonia secondary to mycobacterium TB infection who were admitted for critical care in a single center of King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia from 2004 to 2013.Results:In our review of 350 patients with community-acquired pneumonia admitted to Intensive Care Unit, 11 cases of TB complicated with ARDS were identified. The mean age of patients was 51.9 years. The median time from hospital admission to pulmonary TB diagnosis and start of therapy was 5 days, while the median time from onset of symptoms to initiation of treatment was 18 days. The mortality rate was 64%, and the median length of hospital stay before death was 21.4 days. Delayed treatment, as well as high acute physiology and chronic health evaluation II and CURB-65 scores at presentation, were independent risk factors for death.Conclusion:Patients with pulmonary TB infrequently present to intensive care with acute symptoms that meet all criteria for ARDS. Such a presentation of TB carries a high mortality risk.

show abstract

“…The current model differs from the model in our prior study 19 in at least 4 ways: 1) We did not include clinical manifestation in the analysis of the previous model 19 ; 2) In the present study, we set the β value > 0 and <5 with a relative score of 1 and an estimated β value > 5 (the estimated β value = 5.376) was given a relative score of 2; 3) In the prior study, we divided the larger estimated β value by the smallest estimated β value to obtain the relative score 20 ; 4) The scoring of the present study is simpler and easier to use, and was not confounded by the use of bronchiectasis as a predictor, which may be due to the artifact of pseudo-bronchiectasis. Moreover, in the present study, owing to that fact that ICU is a critical source for severe nosocomial infection, we enrolled patients with (−, +, −), (−.…”

Section: Resultsmentioning

confidence: 99%

“…Although the current model does not replace the need for culture evaluation or the PCR results, diagnosis of [iSN-aPTB] is often delayed while waiting for culture results and diagnosis is often made based on the [CXR + clinical response] 20 , resulting in empirical anti-TB treatment without microbiological confirmation 21 . Results of this study highlight the HRCT model, demonstrating that it is a useful method in patients having ALI without significant differences in the symptoms/signs between the [iSN-aPTB] and the [non-aPTB-PD], or respiratory specimens are unavailable and CXR reveals atypical presentation 22 .…”

Section: Discussionmentioning

confidence: 99%

Predictors of Initial Smear-Negative Active Pulmonary Tuberculosis with Acute Early Stage Lung Injury by High-Resolution Computed Tomography and Clinical Manifestations: An Auxiliary Model in Critical Patients

Yeh

2019

Sci Rep

View full text Add to dashboard Cite

This study evaluated the diagnostic use of high-resolution computed tomography (HRCT), chest X-ray (CXR), and clinical manifestations (CM) to identify initial smear-negative (iSN) active pulmonary tuberculosis (aPTB) [iSN-aPTB] in patients with iSN-pulmonary diseases (PD) and acute lung injury (ALI). In the derivation cohort, the [iSN-PD] with ALI patients were divided into the [iSN-aPTB] (G1, n = 26) and [non-aPTB-PD] (G2, n = 233) groups. Lung morphology, number, and lobar (segmental) distribution were evaluated using CXR and HRCT. A multivariate analysis was performed to identify independent variables associated with G1, which were used to generate predictive score models for G1. The predictive model was validated in a separate population of patients (n = 372) with [iSN-PD] and (ALI). The validated model for [HRCT (CXR + Hypoalbuminemia)] had 93.5% (25.8%) sensitivity, 99.5% (89.4%) specificity, and a negative predictive value of 99.5% (93.0%). For [iSN-aPTB], the post-test probability in the derivation cohort (prevalence = 10%), validation cohort (prevalence = 8.3%), and the given prevalence (prevalence = 1%) was 88.7%, 94.4%, and 41.5%, respectively. The HRCT model effectively identified the [iSN-aPTB] subjects among the [iSN-PD] with ALI, regardless of CM. The [non-aPTB-PD] were also correctly classified by the HRCT and [CXR + Hypoalbuminemia] models.

show abstract

Pulmonary tuberculosis presenting with acute respiratory distress syndrome (ARDS): A case report and review of literature

Cited by 9 publications

References 11 publications

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Acute respiratory distress syndrome complicating community-acquired pneumonia secondary to mycobacterium tuberculosis in a tertiary care center in Saudi Arabia

Predictors of Initial Smear-Negative Active Pulmonary Tuberculosis with Acute Early Stage Lung Injury by High-Resolution Computed Tomography and Clinical Manifestations: An Auxiliary Model in Critical Patients

Contact Info

Product

Resources

About