Pulmonary talcosis in the setting of cosmetic talcum powder use

Cho, Alvin; Amirahmadi, Roxana; Ajmeri, A.; Deepak, Janaki

doi:10.1016/j.rmcr.2021.101489

Cited by 3 publications

(2 citation statements)

References 10 publications

(30 reference statements)

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“…Histopathological tests such as bronchoalveolar lavage and transbronchial biopsies are needed for tissue diagnosis. The presence of negatively birefringent, needle-shaped particles of talc seen within the giant cells and in the areas of pulmonary fibrosis under polarized light confirms the diagnosis [104,105]. The natural history of pulmonary talcosis is slowly progressive similar to other forms of pneumoconiosis, even after exposure has ceased [106].…”

Section: Talcosissupporting

confidence: 53%

“…Pulmonary talcosis is a rare but debilitating form of pneumoconiosis that is difficult to diagnose due to its nonspecific signs and symptoms. The causative agent, talc, is a magnesium silicate mineral found in various household products such as ceramics, paper, oral medications, and cosmetics such as baby powder [104]. The disease most commonly affects men in their 40s [105].…”

Section: Talcosismentioning

confidence: 99%

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Understanding Pneumoconiosis, A Misdiagnosed Subtype of Diffuse Interstitial Lung Disease

Coral

2023

IJOPRS

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Pneumoconiosis is a lung disease caused by inhalation of organic or nonorganic airborne dust and fibers for an extended period. The clinical presentation can vary depending on the dust type and the disease's severity. Common symptoms include cough, shortness of breath, chest tightness, and wheezing. Pneumoconiosis is one of the most common occupational diseases in the world. The most frequent types include asbestosis, silicosis, anthracosis, berylliosis, siderosis, and talcosis. It is important to note that there are other types of pneumoconiosis. However, due to their exceptionally rare occurrence, they are not addressed in this review. Diagnosis of pneumoconiosis typically involves a thorough medical history, physical examination, and imaging tests such as chest X-rays and CT scans. Pulmonary function tests may also be used to assess lung function. The prognosis of pneumoconiosis depends on several factors, including the type and severity of the disease, as well as the patient's age, overall health, and exposure to the causative dust. In some cases, the condition may progress and lead to severe respiratory impairment, while in other cases, the symptoms may be mild and manageable with treatment. Treatment strategies are mainly tailored to avoid further exposure to inhalants, smoking suspension, pulmonary rehabilitation, and symptomatic treatment. Patients with end-stage disease may be candidates for lung transplants. This narrative review article presents an overview of the most common types of pneumoconiosis.

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Section: Talcosissupporting

confidence: 53%

Section: Talcosismentioning

confidence: 99%

Understanding Pneumoconiosis, A Misdiagnosed Subtype of Diffuse Interstitial Lung Disease

Coral

2023

IJOPRS

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Rapid detection of talc content in flour based on near-infrared spectroscopy combined with feature wavelength selection

2022

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Excessive illegal addition of talc in flour has always been a serious food safety issue. To achieve rapid detection of the talc content in flour (TCF) by near-infrared spectroscopy (NIRS), this study used a Fourier transform near-infrared spectrometer technique. The identification of efficient spectral feature wavelength selection (FWS), such as backward interval partial-least-square (BiPLS), competitive adaptive reweighted sampling (CARS), hybrid genetic algorithm (HGA), and BiPLS combined with CARS; BiPLS combined with HGA; and CARS combined with HGA, was also discussed in this paper, and the corresponding partial-least-square regression models were established. Comparing with whole spectrum modeling, the accuracy and efficiency of regressive models were effectively improved using feature wavelengths of TCF selected by the above algorithms. The BiPLS, combined with HGA, had the best modeling performance; the determination coefficient, root-mean-squared error (RMSE), and residual predictive deviation of the validation set were 0.929, 1.097, and 3.795, respectively. BiPLS combined with CARS had the best dimensionality reduction effect. Through the FWS by BiPLS combined with CARS, the number of modeling wavelengths decreased to 72 from 1845, and the RMSE of the validation set was reduced by 11.6% compared with the whole spectra model. The results showed that the FWS method proposed in this paper could effectively improve detection accuracy and reduce modeling wavelength variables of quantitative analysis of TCF by NIRS. This provides theoretical support for TCF rapid detection research and development in real-time.

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Effect of enclosing terpenoids-rich Boswellia Carterri ethyl acetate extract in binary cyclodextrin based oligomer nano-complex for improving its activity via counteracting ICAM-1, Ilβ4 and LTB4 pathways in respiratory distressed rats

Ibrahim,

mohammed,

Taleb

et al. 2024

Preprint

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Boswellia carterii (BC) resins plants have a long historical background as a treatment for inflammation, as indicated by information originating from multiple countries. Twenty-seven diterpenoids have been identified in ethylacetate and total methanol BC, comprising seventeen boscartins of the cembrane-type diterpenoids and ten boscartols of the prenylaromadendrane-type diterpenoids. Moreover, twenty-one known triterpenoids have also been found, encompassing nine tirucallane-type, six ursane-type, four oleanane-type, and two lupane-type. The cembrane-type diterpenoids hold a significant position in pharmaceutical chemistry and related industries due to their captivating biological characteristics and promising pharmacological potentials. Extraction of BC, creation and assessment of nano sponges loaded with either B. Carterii plant extract or DEX, are the subjects of our current investigation. With the use of ultrasound-assisted synthesis, nano sponges were produced. The entrapment efficiency (EE%) of medications in Nano sponges was examined using spectrophotometry. Nano sponges were characterized using a number of methods. Within Nano sponges, the EE% of medicines varied between 98.52± 0.07 and 99.64± 1.40%. The nano sponges' particle sizes varied from 105.9±15.9 to 166.8±26.3 nm. Drugs released from Nano sponges using the Korsmeyer-Peppas concept. In respiratory distressed rats, the effects of BC plant extract, DEX salt and their nano formulations (D1, D5, P1 and P1), were tested. Treatment significantly reduced ICAM-1, LTB4, and ILβ4 levels and improved histopathologic profiles, when compared to the positive control group. Boswellia extract and its Nano sponge formulation P1 showed promising therapeutic effects. The effect of P1 may be due to synergism between both the extract and the formulation. This effect was achieved by blocking both ICAM-1 and LTB4 pathways, therefore counteracting the effects of talc powder.

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Pulmonary talcosis in the setting of cosmetic talcum powder use

Cited by 3 publications

References 10 publications

Understanding Pneumoconiosis, A Misdiagnosed Subtype of Diffuse Interstitial Lung Disease

Understanding Pneumoconiosis, A Misdiagnosed Subtype of Diffuse Interstitial Lung Disease

Rapid detection of talc content in flour based on near-infrared spectroscopy combined with feature wavelength selection

Effect of enclosing terpenoids-rich Boswellia Carterri ethyl acetate extract in binary cyclodextrin based oligomer nano-complex for improving its activity via counteracting ICAM-1, Ilβ4 and LTB4 pathways in respiratory distressed rats

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