Pulmonary Sporotrichosis

McGavran, Malcolm H.; Kobayashi, George S.; Newmark, Leonard; Newberry, Marcus; Miller, Carol; Harford, Carl G.

doi:10.1378/chest.56.6.547

Cited by 10 publications

(2 citation statements)

References 5 publications

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“…6,7 "S. schenckii" was implicated as the etiologic agent in more than 90% of the cases reported without speciation of the complex as most reports originated from an era when molecular sequencing methods were not available, the knowledge regarding cryptic species within the S. schenckii complex had not been established, and phenotyping methods could not lead to speciation. Coinfection with other bacteria (Streptococcus pneumoniae, 45 Klebsiella species, [46][47][48] Pseudomonas aeruginosa, [49][50][51] Proteus species, 50 Staphylococcus aureus, 6 Actinomyces israelii 52 ), mycobacteria (Mycobacterium tuberculosis, 53,54 M. avium complex 55 ), and fungi (Aspergillus species, 56 Pneumocystis jirovecii, 57 Candida species 58 ) has also been previously reported.…”

Section: Clinical Featuresmentioning

confidence: 98%

Pulmonary Sporotrichosis: An Evolving Clinical Paradigm

Aung

Spelman

Thompson

2015

Semin Respir Crit Care Med

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In recent decades, sporotrichosis, caused by thermally dimorphic fungi Sporothrix schenckii complex, has become an emerging infection in many parts of the world. Pulmonary infection with S. schenckii still remains relatively uncommon, possibly due to underrecognition. Pulmonary sporotrichosis presents with distinct clinical and radiological patterns in both immunocompetent and immunocompromised hosts and can often result in significant morbidity and mortality despite treatment. Current understanding regarding S. schenckii biology, epidemiology, immunopathology, clinical diagnostics, and treatment options has been evolving in the recent years with increased availability of molecular sequencing techniques. However, this changing knowledge has not yet been fully translated into a better understanding of the clinical aspects of pulmonary sporotrichosis, as such current management guidelines remain unsupported by high-level clinical evidence. This article examines recent advances in the knowledge of sporotrichosis and its application to the difficult challenges of managing pulmonary sporotrichosis.

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Section: Clinical Featuresmentioning

confidence: 98%

Pulmonary Sporotrichosis: An Evolving Clinical Paradigm

Aung

Spelman

Thompson

2015

Semin Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…This condition is very unusual and only half a dozen cases were reported in the literature before 1965 [1][2][3][4]. Since then several additional cases have been reported.We followed a case of unrecognized sporotrichosis with cavitation for a period of almost 5 years [8,11]. The patient was treated for pulmonary tuberculosis with a progressive worsening of the condition, and only on his last and final admission to the hospital was the diagnosis made when a dissemination of the infection throughout the body occurred [7].…”

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confidence: 99%