Pulmonary oxygen toxicity in the rat and the role of histamine

Taurine which has antioxidant effects is also known to have effects on cell proliferation, inflammation and collagenogenesis. The aim of this study was to investigate the effect of taurine on incisional skin wounds.The mice incised on the dorsal area were divided into control and experimental groups. Saline was injected intraperitoneally to half of the animals in the control group and locally applied to the other half. Fifty mM taurine solution was given intraperitoneally to the first half of the experimental animals and locally to the second half of the experimental group.After four days of treatment, malondialdehyde (MDA) and histamine levels as well as the tensile strength of the wound tissue were measured. Structural alterations in epidermis and dermis were histologically evaluated.The locally administreated taurine significantly increased wound tensile strength by decreasing the MDA and histamine levels and prevented the degranulation of the mast cells. These observations suggest that taurine may be useful on wound healing.

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Effect of taurine on wound healing

Dinçer

Babül

Erdoğan

et al. 1996

Amino Acids

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Plenary lecture Free radicals as endogenous histamine releasers

et al. 1988

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Effects of intratracheal administration of xanthine plus xanthine oxidase on lung antioxidant enzymes, lipid peroxidation, and collagen in hamsters

Giri¹,

Hyde²,

Emau³

et al. 1988

Experimental and Molecular Pathology

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Pulmonary oxygen toxicity in the rat and the role of histamine

Cited by 6 publications

References 13 publications

Effect of taurine on wound healing

Effect of taurine on wound healing

Plenary lecture Free radicals as endogenous histamine releasers

Effects of intratracheal administration of xanthine plus xanthine oxidase on lung antioxidant enzymes, lipid peroxidation, and collagen in hamsters

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